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Anjum Hassan, MD

Associate Professor, Pathology & Immunology

Phone314-747-1120

Fax314-747-4392

Emailahassan22@wustl.edu

Additional Titles

  • Director, Hematopathology Fellowship

Research Interests

My past research involved work on small lymphocytic leukemia, a project that eventually involved setting up the system for direct sequencing of immunoglobulin genes from paraffin sections. Another focus of my previous research involved studying the pathogenesis of Multiple Myeloma, a pilot study to optimize PCR detection of ras mutations in archival material in the Department of Pathology and Immunology and correlating that with t(4;14) and t(11;14) in established myeloma cases. For additional information on my papers, please refer to my portfolio. My current research focuses mainly of translational projects with a focus on B- cell Non-Hodgkin lymphoma and research related to reviews and updates of previously authored book chapters.

Service to the University

2014 – Present Coarse Director, WUSM hematopathology electives
2010 – Present Medical Director FFPE FISH in Cytogenomics and Molecular Pathology
2008 – Present Member, Committee on Admissions, Washigton Univ. School of Medicine
2006 – 2009 Assistant Director, Fluorescent in-situ Hybridization Lab in Anatomic Pathology
2005 – 2008 Second year Adrenal pathology course
2005 – Present Second year medical student Hematopathology Lab curriculum

Clinical Interests

  • Hematopathology

Publications

Xiao J , Nguyen T, Frater J.L, Kreisel F, Hassan A.. Evolution of Mantle Cell Lymphoma “in situ” Contributing to Immune Thrombocytopenia.. Leukemia and lymphoma., 2014
Klein J.L, Nguyen T.T., Bien-Willner G, Chen L, Foyil K.V,Bartlett N, Duncavage E.J, Hassan A, Frater J.L, Kreisel F. CD163 is a more useful immunohistochemical stain than CD68 in predicting outcome of patients with classical Hodgkin lymphoma.. Am J Clin Pathol, 2014
Gru AA, Kreisel F, Duncavage E, Nguyen TT, Hassan A, Frater J. Acute EBV infection masquerading as “in-situ follicular lymphoma”: A pitfall in the differential diagnosis of this entity. Diagn Pathol, 2013
Xiandong X, Hassan A. Hairy cell leukemia misdiagnosed as Large cell lymphoma: Immunohistochemical studies aiding differential diagnosis.. J applied hematol, 2013
Hussaini MO, Klein J, Xiao J, Frater J.L, Kreisel F, Hassan A.. Richter Syndrome: an Unusual Report of Concurrent Small Lymphocytic Lymphoma, Hodgkin Lymphoma, and Anaplastic Plasmacytoma.. J applied hematol, 2013
Xiandong X, Hassan A. Extranodal marginal zone lymphoma arising in a patient with chronic myelogenous leukemia on long term decitabine therapy. Leukemia and lymphoma, 2013
Gru A.A, Hussaini M, Nguyen T, Frater J.L, Kreisel F, Hassan A. High prevalence of 1p36 microdeletions in B-cell non-Hodgkin lymphomas associated with PAX7 loss. Int J Lab Hematol, 2013
Pittman M, Treese S, Chen L, Frater J.L, Nguyen TT, Hassan A. Utility of flow cytometry of cerebrospinal fluid as a screening tool in the diagnosis of central nervous system lymphoma. Arch Pathol Lab Med, 2012
Wang T, Klein JL, Woodard PK, Hassan A, Joseph SM, Ewald GA, Uy GL. Plasmacytoma-like Posttransplant Lymphoproliferative Disease Occurring in a Cardiac Allograft: A Case Report and Review of Literature.. J Clin Oncol, 2012
Deetz C.O, Scott M.G., Ladenson J.H., Seyoum M., Hassan A, Kreisel F.H, Nguyen T.T, Frater J.L.Use of a United States-based laboratory as a hematopathology reference center for a developing country: logistics and results. Int J Lab Hematol, 2012
Warrick J, Luo J, Robirds D, Branson J, Frater J.L, Kreisel F, Hassan A, Nguyen T.T.Gastrointestinal lymphomas in a North American population: clinicopathologic features from one major Central-Midwestern United states tertiary care medical center. Diagn Pathol, 2012
Yeung C.C, Mills JC, Hassan A, Kreisel F.H, Nguyen T.T, Frater J.L. A novel marker of plasmacytic differentiation. Appl Immunohistochem Mol Morphol, 2012
Hussaini M, Kreisel F , Hassan A. Impact of proliferative indices and tumor suppressor genes on treatment response in marginal zone lymphomas. comp clin pathol, 2012
Welch J S, Klco J M, Gao F, Cashen A. F, Uy G. L, Stockerl-Goldstein K. E, Abboud C.M , Westervelt P, DiPersio J.F , Hassan A, Vij R. . Combination Decitabine, Arsenic trioxide and Ascorbic Acid for the Treatment of Myelodysplastic syndrome and Acute Myeloid Leukemia:a phase I study. Am J Hematol, 2011
Amador-Ortiz C, Hurley M.Y, Ghahramani G.K, Frisch S, Klco J.M, Lind A.C, Nguyen T.T, Hassan A, Kreisel F.H, Frater J.L. Use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma. J Cutan Path, 2011
Klco J.M, Welch J.S, Nguyen T.T, Hurley M.Y, Kreisel F, Hassan A, Lind A.C, Frater J.L. State of art in myeloid sarcoma. Int J Lab Hematol, 2011
Kreisel F, Kulkarni S, Kerns R. T, Hassan A , Deshmukh H, Nagarajan R , Frater J. L, Cashen A.High-resolution array comparative genomic hybridization (aCGH) identifies copy number alterations in diffuse large B-cell lymphoma that predict response to immuno-chemotherapy. Cancer Genet, 2011
Amador-Ortiz C, L. Chen, A. Hassan, J.L. Frater, R. Burack, T.T. Nguyen, F. Kreisel. Combined core needle biopsy and fine needle aspiration with ancillary Studies correlate highly with traditional techniques in the diagnosis of nodal-based lymphoma. Am J Clin Pathol., 2011
Klco J.M,Kulkarni S, Kreisel F.H, Nguyen T.T, Hassan A, Frater J.L. Immunohistochemical analysis of monocytic leukemias: utility of CD14 and Krüppel-like factor 4, a novel monocytic marker. Am J Clin Pathol, 2011
Nanua S, Bartlett N, Hassan A, Robirds D, Brawson J, Frater J. L, Nguyen T.T, Kreisel. Composite diffuse large B-cell lymphoma and precursor B lymphoblastic lymphoma presenting as a double-hit lymphoma with MYC and BCL2 translocation.. J clin pathol, 2011
Yeung C CS, Powers MLE, Kreisel F.H, Frater J. L, Zehnbauer B. A, Burack R, Hassan A.Relevance of Somatic Hypermutation and Interphase Cytogenetics in Lymphomatous Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL). Int J Surg Pathol, 2011
Hassan A. Minimal residual disease testing in acute leukemia. J app hematol, 2011
Ansstas G, Mosley J.C, Bryant G, Hassan A, Amador-Ortiz C, Procknow E, Vij R. Efficacy and Tolerability of PTK787/ZK 222584 in a Phase II Study of Post-Transplant Maintenance Therapy in Patients with Multiple Myeloma Following High-Dose Chemotherapy and Autologous Stem Cell Transplant. Leukemia and Lymphoma, 2010
Klco J.M, Vij R, Kreisel F.H, Hassan A, Frater J.L. Molecular pathology of myeloproliferative neoplasms. Am J Clin Pathol, 2010
Kreisel F.H, Frater J, Hassan A, El-Mofty S.K. Cystic lymphoid hyperplasia of the parotid gland in HIV-positive and HIV-negative patients. Quantitative Immunopathology, 2010
Cai S F., Cao X, Hassan A, Fehniger TA., and Ley TJ. Granzyme B is not required for regulatory T cell mediated suppression of graft-versus-host Disease. Blood, 2010
Klco J. M, Geng B, Brunt E. M, Hassan A, Nguyen T. D, Kreisel F. H, Lisker-Melman M, Frater J. L.Bone marrow biopsy in patients with hepatitis C virus infection: Spectrum of findings and diagnostic utility. Am J Hematol, 2010
Krishmurthy S, Hassan A, Frater J. L, Paessler M. E, Kreisel F. Pathologic and clinical features of Hodgkin lymphoma-like post transplant lymphoproliferative disease. Int J Surg Pathol, 2010
O’Neal J, Molitoris A, Gao F, Hassan A , Monahan R, Barrios S, Weilbaecher K, Vij R, Tomasson M. Neurobeachin (NBEA) is a target of recurrent interstitial deletions at 13q13 in patients with MGUS and multiple myeloma. Experimental Hematology, 2009
Klco JM, Kreisel FH, Zehnbauer BA, Kulkarni S, Hassan A, Frater JL. The spectrum of adult B-lymphoid leukemias with BCR-ABL: molecular diagnostic, cytogenetic, and clinical laboratory perspectives.. Am J Hematol, 2008
Powers M LE, Watson BW, Frater JL, Kreisel F, Hassan A. Peripheral Eosinophilia Camouflaging Anaplastic Large Cell Lymphoma. Int J. Surg. Pathol, 2008
Zhao, XF, Hassan A, Perry A, Ning Y, Stass SA, Dehner LP. B-cell lymphomas with atypical morphology and c-myc rearrangements. Int J clin exp pathol 1(1): 65-74,2008 ., 2008
Hassan A, Kreisel F, Lewis J, Gardner L, El-Mofty S.. Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status. Head and Neck pathology, Oct 2007, available on line. DOI 10.1007/s12105-007-00060-5., 2007
Kaleem Z, Hassan A.. Pathologic Quiz Case: Multiple lytic bone lesions in an 85-year-old man.. Arch Pathol Lab Med 129:e148-150, 2005 Abstract
Hassan A, Yerian LM, Kuan SF, Xiao SY, Hart J, Wang HL. Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin D1, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polyps.. Hum Pathol 35:328-334, 2004 Abstract
Kaleem Z, Hassan A, Pathan MH, White G.. Flow Cytometric Evaluation of Posttransplant B-Cell Lymphoproliferative Disorders.. Arch Pathol Lab Med 128:181-186, 2004 Abstract
Hassan A, Bennet A, Bhalla S, Ylagan LR, Mutch D, Dehner LP. Paraganglioma of the vagina: Ultrastructural and immunohistochemical study.. Int J Gynecol Pathol, 22:404-406, 2003 Abstract
Liapis H, Hassan A. Idiopathic light chain deposition disease without clinical evidence of Multiple Myeloma. Int Urol Nephrol 35:579-580, 595-596, 2003 Abstract
Coopersmith CA, Lowell JA, Hassan A, Howard TK. Hepatocellular carcinoma in a patient with focal nodular hyperplasia.. Arch Pathol Lab Med 128:181-186, 2002