Aersilan Alimasi, PhD

Division

• Anatomic & Molecular Pathology

Lab Website

• Teitelbaum Lab

Education

• BS: (Medical Imaging/Radiology) Xinjiang Medical University, Xinjiang, China
• PhD: (Molecular Diagnosis) Chiba University, Japan

Research Interests

Bone homeostasis is a dynamic process that involves the balanced regulation of bone formation and bone resorption. Any disruption in this balance can lead to various bone disorders, such as osteoporosis, osteopetrosis, and Paget’s disease.SNX10 is a member of the sorting nexin (SNX) family of proteins that has been implicated in various cellular processes, including protein trafficking, endosomal sorting, and autophagy. Recent studies have suggested that SNX10 may play a critical role in regulating bone homeostasis by modulating the activity of osteoclasts, the main cell type involved in bone remodeling. My research is focused on investigating the specific mechanisms by which SNX10 protein modulates bone homeostasis.

Publications

MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway. Aersilan A, Hashimoto N, Yamagata K, Yokoyama M, Nakayama A, Shi X, Nagano H, Sakuma I, Nohata N, Kinoshita T, Seki N, Rahmutulla B, Kaneda A, Zhahara SN, Gong Y, Nishimura M, Kawauchi S, Kawakami E, Tanaka T. Sci Rep. 2022 Nov 2;12(1):18443. doi: 10.1038/s41598-022-23205-w. PMID: 36323841

Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson’s disease. Kakinuma S, Beppu M, Sawai S, Nakayama A, Hirano S, Yamanaka Y, Yamamoto T, Masafumi C, Aisihaer X, Aersilan A, Gao Y, Sato K, Sakae I, Ishige T, Nishimura M, Matsushita K, Satoh M, Nomura F, Kuwabara S, Tanaka T. eNeurologicalSci. 2020 Apr 6;19:100239. doi: 10.1016/j.ensci.2020.100239. eCollection 2020 Jun. PMID: 32346620