Kevin Bowling, PhD

Division

• Genomic & Molecular Pathology

Education

• BS: University of Alabama, Tuscaloosa, AL, 2003
• MS: University of Alabama, Tuscaloosa, AL, 2007
• PhD: University of Alabama, Tuscaloosa, AL, 2008
• Postdoctoral Fellowship, HudsonAlpha Institute for Biotechnology, Huntsville, AL, 2013

Clinical Interests

• Rare disease diagnostics
• Exome and genome sequencing
• Variant analysis and interpretation
• New disease gene discovery

Selected Publications

Funderburk CD*, Bowling KM*, Xu D, Huang Z, O’Donnell JM. A typical N-terminal extensions confer novel regulatory properties on GTP cyclohydrolase isoforms in Drosophila melanogaster. J Biol Chem. 2006;281(44):33302-12. PMID: 16966327 *Equal contribution

Chaudhuri A, Bowling KM, Funderburk CD, Lawal H, Inamdar A, Wang Z, O’Donnell JM. Interaction of genetic and environmental factors in a Drosophila parkinsonism model. J Neurosci. 2007 Mar 7;27(10)2457-67. PMID: 17344383; PMCID: PMC6672491

Bowling KM*, Huang Z*, Xu D, Ferdousy F, Funderburk CD, Karnik N, Neckameyer W, O’Donnell JM. Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis. J Biol Chem. 2008;283(46):31449-59. PMID: 18801743; PMCID: PMC2581565 *Equal contribution

Bowling KM, Thompson ML, Amaral MD, Finnila CR, Hiatt SM, Engel KL, Cochran JN, Brothers KB, East KM, Gray DE, Kelley WV, Lamb NE, Lose EJ, Rich CA, Simmons S, Whittle JS, Weaver BT, Nesmith AS, Myers RM, Barsh GS, Bebin EM, Cooper GM. Genomic diagnosis for children with intellectual disability and/or developmental delay. Genome Med. 2017;9(1):43. PMID: 28554332; PMCID: PMC5148144

Ramaker RC*, Bowling KM*, Lasseigne BN*, Hagenauer MH, Hardigan AA, Davis NS, Gertz J, Cartagena PM, Walsh DM, Vawter MP, Jones EG, Schatzberg AF, Barchas JD, Watson SJ, Bunney BG, Akil H, Bunney WE, Li JZ, Cooper SJ, Myers RM. Post-mortem molecular profiling of three psychiatric disorders. Genome Med. 2017;9(1):72. PMID: 28754123; PMCID: PMC5534072 *Equal contribution

Thompson ML, Finnila CR, Bowling KM, Brothers KB, Neu MB, Amaral MD, Hiatt SM, East KM, Gray DE, Lawlor JMJ, Kelley WV, Lose EJ, Rich CA, Simmons S, Levy SE, Myers RM, Barsh GS, Bebin EM, Cooper GM. Genomic sequencing identifies secondary findings in a cohort of parent study participants. Genet Med. 2018;20(12):1635-43. PMID: 29790872; PMCID: PMC6185813

Neu MB, Bowling KM, Cooper GM. Clinical utility of genomic sequencing. Curr Opin Pediatr. 2019;31(6):732-8. PMID: 31693580; PMCID: PMC7197344

Bowling KM, Thompson ML, Gray DE, Lawlor JMJ, Williams K, East KM, Kelley WV, Moss IP, Absher DM, Partridge EC, Hurst ACE, Edberg JC, Barsh GS, Korf BR, Cooper GM. Identifying rare, medically relevant variation via population-based genomic screening in Alabama: opportunities and pitfalls. Genet Med. 2021;23(2):280-8. PMID: 32989269

Hiatt SM, Lawlor JMJ, Handley LH, Ramaker RC, Rogers BB, Partridge EC, Boston LB, Williams M, Plott CB, Jenkins J, Gray DE, Holt JM, Bowling KM, Bebin EM, Grimwood J, Schmutz J, Cooper GM. Long-read genome sequencing for the molecular diagnosis of neurodevelopmental disorders. HGG Adv. 2021;2(2). PMID: 33937879; PMCID: PMC8087252

Bowling KM, Thompson ML*, Latner DR, Finnila CR, Hiatt SM, Amaral MD, Kelley WV, East KM, Greve V, Cochran ME, Gray DE, Lawlor JMJ, Meddaugh H, Cannon A, Luedecke A, Jackson KE, Hendon LG, Janani HM, Johnston M, Merin LA, Deans SL, Tuura C, Hughes T, Williams H, Laborde K, Neu MB, Patrick-Esteve J, Hurst ACE, Brothers KB, Savich R, Spedale SB, Knight SJ, Barsh GS, Korf BR, Cooper GM. Genome sequencing as a first-line diagnostic test for hospitalized infants. Genet Med. 2021 Nov 27:S1098-3600(21)05400-9. Epub ahead of print. PMID: 34930662 *Equal contribution

Bowling KM*, Thompson ML*, Kelly MA, Scollon S, Slavotinek AM, Powell BC, Kirmse BM, Hendon LG, Brothers KB, Korf BR, Cooper GM, Greally JM, Hurst ACE. Return of non-ACMG recommended incidental genetic findings to pediatric patients: considerations and opportunities from experiences in genomic sequencing. Genome Med. 2022 Nov 21;14(1):131. PMID: 36414972; PMCID: PMC9682742. *Equal contribution

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Assistant
Lori Scantlan
314-747-8071
llscantlan@wustl.edu