Cheryl Lichti, PhD

Division

• Immunobiology

Education

• BA, Chemistry, Hendrix College, Conway, AR
• PhD, Organic Chemistry, Duke University, Durham, NC
• Postdoctoral Research Associate, Organic Chemistry, University of Colorado, Boulder, CO

Recognition(s)

• 2021 Outstanding Paper of the Year Award, Department of Pathology and Immunology

Research Interests

My work is focused in the unbiased sequence characterization of major histocompatibility complex (MHC)-bound ligands by mass spectrometry, with a specific focus on post-translationally modified neoantigens. My work is collaborative in nature and currently involves studies of type 1 diabetes, tumor immunology, and neurodegenerative diseases.

Selected Publications

Wan X, Zinselmeyer BH, Zakharov PN, Vomund AN, Taniguchi R, Santambrogio L, Anderson MS, Lichti CF, Unanue ER, Pancreatic islets communicate with lymphoid tissue via exocytosis of insulin peptides. Nature 2018 Aug: 560 (7716): 107-111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090537/

Alspach E, Lussier DM, Miceli AP, Kizhvatov I, DuPage M, Luoma AM, Meng W, Lichti CF, Esaulova E, Vomund AN, Runci D, Ward JP, Gubin MM, Medrano RFV, Arthur CD, White JM, Sheehan KCF, Chen A, Wucherpfennig KW, Jacks T, Unanue ER, Artyomov MN, Schreiber RD. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature 2020; 574(7780):696-701. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858572/

Wan X, Vomund AN, Peterson OJ, Chervonsky AV, Lichti CF, Unanue ER, The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides. Nat Immunol. 2020 Apr;21(4):455-463. (co-corresponding author) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117798/

Lichti CF. Identification of spliced peptides in pancreatic islets uncovers errors leading to false assignments. Proteomics. 2021 (7-8); 2000176. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/pmic.202000176

Vomund AN, Lichti CF, Peterson OJ, Arbelaez AM, Wan X, Unanue ER. Blood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets. J. Exp. Med. 2021 Jun 7; 218 (6). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034384/

Meng W, Takeuchi Y, Ward JP, Sultan H, Arthur CD, Mardis ER, Artyomov MN, Lichti CF, Schreiber RD. Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry. Cancer Immunol Res. 2024 Aug 1;12(8):988-1006. doi: 10.1158/2326-6066.CIR-23-0900. PubMed PMID: 38768391. https://pubmed.ncbi.nlm.nih.gov/38768391/