Rafael Czepielewski, PhD

Instructor, Department of Pathology & Immunology

Education

  • BS, Biological Sciences: Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil (2008)
  • MS, Cellular and Molecular Biology (Immunology): PUCRS, Porto Alegre, Brazil (2009-2011)
  • PhD, Cellular and Molecular Biology (Immunology): PUCRS, Porto Alegre, Brazil (2012-2016)
  • PhD, Fellowship, Department of Immunology, Icahn School of Medicine at Mount Sinai, New York City, NY (2013-2014)
  • Postdoctoral Research: Department of Pathology & Immunology, Division of Immunobiology, Washington University Medical School, St. Louis, MO (2016-2021)

Twitter Handle

  • @rafacze

Recognition

  • Lawrence C. Pakula, MD IBD Education & Innovation Fund IBD Center, Washington University School of Medicine (2019)
  • Young Investigator Award, Lymphatic Forum (2021)

Research Interests

My research is focused on understanding the role of lymphatic vasculature in the pathogenesis of inflammatory bowel disease and its influences on mucosal immune responses.

Selected Publications

CZEPIELEWSKI, R. S., Erlich, E. C., Onufer, E. J., Young, S., Saunders, B. T., Han, Y., Wohltmann, M., Wang, P. L., Kim, K-H, Kumar, S., Hsieh, C. S., Scallan, J. P., Yang, Y., Zinselmeyer, B. H., Davis, M. J., Randolph, G. J. (2021). Ileitis-associated mesenteric tertiary lymphoid organs arise at lymphatic valves and impede lymph flow in response to tumor necrosis factor. Immunity. S1074-7613(21)00409-X. PMCID: PMC8678349. https://linkinghub.elsevier.com/retrieve/pii/S107476132100409X
Zhang, N., Kim, S. H., Gainullina, A., Erlich, E. C., Onufer, E. J., Kim, J., CZEPIELEWSKI, R. S., et al. (2021). LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth. The Journal of Experimental Medicine, 218(12). PMCID: PMC8575007. https://doi.org/10.1084/jem.20210924
Brioschi, S., Wang, W.-L., Peng, V., Wang, M., Shchukina, I., Greenberg, Z. J., Bando, J. K., Jaeger, N., CZEPIELEWSKI, et al. (2021). Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science, 373(6553), eabf9277. PMCID: PMC8448524. https://doi.org/10.1126/science.abf9277
Li, J., Li, E., CZEPIELEWSKI, et al. (2021). Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell Metabolism, 33(7), 1449-1465.e6. PMCID: PMC8266750. https://doi.org/10.1016/j.cmet.2021.04.019
CZEPIELEWSKI, R. S., Gallerand, A., Gilleron, J., Khedher, N., Randolph, G. J., & Ivanov, S. (2020). Lymphatic and Blood Network Analysis During Obesity. Journal of Visualized Experiments, (165), 1–7. PMID: 33283786. https://doi.org/10.3791/61814
Zhang, N., CZEPIELEWSKI, R. S., et al. (2019). Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity. Journal of Experimental Medicine, 216(6). PMCID: PMC6547866. https://doi.org/10.1084/jem.20182024
Onufer, E. J., CZEPIELEWSKI, R. S., et al. (2019). Lymphatic network remodeling after small bowel resection. Journal of Pediatric Surgery, 54(6), 1239–1244. PMCID: PMC6545263. https://doi.org/10.1016/j.jpedsurg.2019.02.026
Jaeger, N.*, CZEPIELEWSKI, R. S., Bagatini, M., Porto, B. N., & Bonorino, C. (2017). Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species-dependent migration in lung adenocarcinoma cells. Tumor Biology, 39(3), 101042831769432. PMID: 28351312. https://doi.org/10.1177/1010428317694321
CZEPIELEWSKI, R. S., et al. (2017). GRPR antagonist protects from drug-induced liver injury by impairing neutrophil chemotaxis and motility. European Journal of Immunology, 47(4), 646–657. PMID: 28294319. https://doi.org/10.1002/eji.201646394
CZEPIELEWSKI, R. S., et al. (2012). Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils. Proceedings of the National Academy of Sciences, 109(2), 547–552. PMCID: PMC3258617. https://doi.org/10.1073/pnas.1110996109

Assistant
Jennifer Schwierjohn
314-362-3056
j.schwierjohn@wustl.edu