Patrick Collins, PhD

Instructor, Pathology & Immunology

Education

  • BS, Biology: New Mexico Institute of Mining and Technology, Socorro, NM (2006)
  • PhD, Immunology: Vanderbilt University, Nashville, TN (2011)

Recognition

  • David K. Shortess Award for Outstanding Undergraduate Student, 2006
  • Pre-doctoral training grant, Immunobiology of Blood and Vascular Systems, 2007-2009
  • Member: Microbes and Defense Academy Honor Society, 2008-2010
  • Post-doctoral fellowship – NIH Training Program in Immunology and Immunogenetics, 2012-2014

Research Interests

Dr. Collins has a long-standing interest in the epigenetic regulation of lymphocyte development, and contribution to pathological conditions. Currently, his work focuses on: (i) the transcriptional mechanisms that unify innate lymphoid cell and adaptive lymphoid cell development and (ii) the epigenetic mechanisms that protect chromatin during lymphocyte development and antigen receptor recombination.

Publications

Collins, Patrick L., Shaojing Chang, Melodie Henderson, Mohammed Soutto, Georgia M. Davis, Allyson G. McLoed, Michael J. Townsend, Laurie H. Glimcher, Douglas P. Mortlock, and Thomas M. Aune. “Distal regions of the human IFNG locus direct cell type-specific expression.” The Journal of Immunology 185, no. 3 (2010): 1492-1501.
Collins, Patrick L., Melodie A. Henderson, and Thomas M. Aune. “Diverse functions of distal regulatory elements at the IFNG locus.” The Journal of Immunology 188, no. 4 (2012): 1726-1733.
Collier, Sarah P., Patrick L. Collins, Christopher L. Williams, Mark R. Boothby, and Thomas M. Aune. “Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.” The Journal of Immunology 189, no. 5 (2012): 2084-2088.
Collins, Patrick L., Melodie A. Henderson, and Thomas M. Aune. “Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element.” Genes and immunity 13, no. 6 (2012): 481-488.
Collins, Patrick L., and Eugene M. Oltz. “Histone methylation keeps the brakes on autophagy.” Molecular and cellular biology 33, no. 20 (2013): 3974-3975.
Collins, Patrick L., Katherine E. Kyle, Takeshi Egawa, Yoichi Shinkai, and Eugene M. Oltz. “The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.” Proceedings of the National Academy of Sciences 112, no. 27 (2015): 8367-8372.
Kaiko, Gerard E., Stacy H. Ryu, Olivia I. Koues, Patrick L. Collins, Lilianna Solnica-Krezel, Edward J. Pearce, Erika L. Pearce, Eugene M. Oltz, and Thaddeus S. Stappenbeck. “The colonic crypt protects stem cells from microbiota-derived metabolites.” Cell (2016).
Koues, Olivia I.*, Patrick L. Collins*, Marina Cella*, Michelle L. Robinette*, Sofia I. Porter, Sarah C. Pyfrom, Jacqueline E. Payton, Marco Colonna, and Eugene M. Oltz. “Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells.” Cell 165, no. 5 (2016): 1134-1146. *Co-corresponding authors
Rohatgi, Nidhi, Wei Zou, Patrick .L Collins, Tim H Chen, Yousef Abu-Amer, and Steven L. Teitelbaum. “ASXL1 deficiency in mice epigenetically promotes osteoclast formation by demethylating NFATc1” Blood. In press.

Lab Phone: 314-362-5524
Office Location: CSRB, Room 7730