Parker Wilson, MD, PhD

Instructor, Pathology & Immunology

 

Education

  • BS: Johns Hopkins University
  • MD, PhD: Medical University of South Carolina, Charleston, SC (2013)
  • Residency, Anatomic and Clinical Pathology: Yale New Haven Hospital, New Haven, CT (2017)
  • Fellowship, Renal/GU: Yale New Haven Hospital, New Haven, CT (2018)
  • Fellowship, Molecular Genetic Pathology: Washington University in St. Louis

Subspecialization

  • Renal Pathology
  • Molecular Genetic Pathology

Clinical Interests

  • Renal Pathology
  • Molecular Genetic Pathology

Research Interests

I received my B.S. from Johns Hopkins University in Biomedical Engineering with a Concentration in Computer Science and a minor in Mathematics, my Ph.D. in Molecular and Cellular Biology and Pathobiology and my M.D. degree from the Medical University of South Carolina. I completed residency training in Anatomic and Clinical Pathology and a fellowship in combined Renal and Genitourinary Pathology at Yale University. I completed a second fellowship in Molecular Genetic Pathology at Washington University in St. Louis. My clinical training includes extensive experience in the interpretation of native and allograft kidney biopsies, in addition to NGS-based testing for genetic kidney disease. Currently, I am on faculty in the Department of Pathology and Immunology at Washington University in St. Louis where I attend on the renal and molecular pathology services. The majority of my time is devoted to my research on genetic determinants and molecular markers of kidney disease. Recent efforts have applied single cell sequencing to explore the transcriptional changes in early-stage human diabetic nephropathy.

Publications

Wilson PC, Wu H, Kirita Y, et al. The single-cell transcriptomic landscape of early human diabetic nephropathy. Proc Natl Acad Sci U S A. 2019;116(39):19619‐19625. doi:10.1073/pnas.1908706116 PMC6765272
Wilson PC, Love-Gregory L, Corliss M, McNulty S, Heusel JW, Gaut JP. Beyond Panel-based Testing: Exome analysis increases sensitivity for diagnosis of genetic kidney disease. Kidney360 May 2020, https://doi.org/10.34067/KID.0001342020
Kirita Y, Wu H, Uchimura K, Wilson PC, Humphreys BD. Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. PNAS 2020 Jul 7;117(27):15874-15883 PMC7355049
Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA. The Angiotensin 2 Receptor Type 1 Biased Agonist [Sar1, Ile4, Ile8 ]– Ang II is a Negative Allosteric Modulator of Bradykinin B2 Receptor Signaling J Biol Chem, 2013. 288(26): p. 18872-84. PMC3696663
Wilson PC, Fitzgibbon WR, Garrett SM, Jaffa AA, Luttrell LM, Brands MW, El-Shewy HM. Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. Mol Endocrinol. 2015 Jun;29(6):896-908. doi: 10.1210/me.2014-1388. Epub 2015 Apr 14. PMC4447644
Wilson PC, Kashgarian M, Moeckel G. Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis. Clin Kidney J. 2018 Apr;11(2):207-218. doi: 10.1093/ckj/sfx093. Epub 2017 Aug 31. PMC5888814
Chen PM, Wilson PC, Shyer JA, et al. Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis. Sci Transl Med. 2020;12(538):eaay1620. PMID: 32269165 doi:10.1126/scitranslmed.aay1620
Wilson PC, Chagpar AB, Cicek AF, Bossuyt V, Buza N, Mougalian S, Killelea BK, Patel N, Harigopal M. Breast cancer histopathology is predictive of low-risk Oncotype Dx recurrence score. Breast J. 2018 Nov;24(6):976-980. https://doi.org/10.1111/tbj.13117 PMID: 30230117
Zuo T, Wilson P, Cicek AF, Harigopal M. Androgen receptor expression is a favorable prognostic factor in triple-negative breast cancers. Hum Pathol. 2018 Oct;80:239-245 https://doi.org/10.1016/j.humpath.2018.06.003 PMID: 29902579
Yoon EC, Wilson P, Zuo T, Pinto M, Cole K, Harigopal M. High frequency of p16 and SOX10 coexpression but not androgen receptor expression in triple-negative breast cancers. Hum Pathol. 2020 Jun 18;102:13-22. https://doi.org/10.1016/j.humpath.2020.06.004 PMID: 32565323

Assistant

Billie Charlton
314-273-1742
billie.charlton@wustl.edu