Nima Mosammaparast, MD, PhD

Associate Professor, Pathology & Immunology

Additional Titles

  • Co-director, Physician Scientist Training Program

Education

  • BS (magna cum laude): University of Rochester, Rochester, New York (1998)
  • PhD: University of Virginia, Charlottesville, Virginia (2005)
  • MD: University of Virginia, Charlottesville, Virginia (2006)
  • Resident, Pathology: Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Board Certifications

  • American Board of Pathology, Clinical Pathology

Recognition

  • Barry M. Goldwater Fellowship in Science and Mathematics, 1996 – 1998
  • Phi Beta Kappa Honor Society, University of Rochester, 1997
  • Magna cum laude graduate, University of Rochester, 1998
  • Donald R. Charles Memorial Prize in Biology, University of Rochester, 1998
  • NIH Medical Scientist Training Program, 1998 – 2006
  • Robert Wagner Prize, Department of Microbiology, University of Virginia School of Medicine, 2004
  • Michael J. Peach Award, University of Virginia School of Medicine, 2004
  • Chief Resident in Clinical Pathology, Brigham and Women’s Hospital, 2007
  • Paul E. Strandjord Award, Academy of Clinical Laboratory Physicians and Scientists, 2009 – 2011
  • American Cancer Society Institutional Research Award, 2012
  • Siteman Cancer Center Research Development Award, 2014
  • Young Physician-Scientist Award, American Society for Clinical Investigation (ASCI), 2015
  • M.D. Anderson Cancer Center Distinguished Scientist Lecturer, 2018
  • American Cancer Society Research Scholar Award, 2018

Research Interests

We are interested in how cells respond to DNA damaging agents, the signaling involved during such damage, and how these pathways are changed in pathologic states, particularly cancer.

Publications

Select publications:

Zhao Y, Majid MC, Soll JM, Brickner JB, Dango S, Mosammaparast N. Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. EMBO Journal. 2015;1687-703.
Lemacon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou Mosammaparast N, Vindigni A. MRE11 and EXO1 nucleases degrade reversed forks and lead to MUS81-dependent fork rescue in BRCA2-deficient cells. Nature Communications. 2017;8:860.
Brickner JB, Soll JM, Lombardi PM, Vagbo CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gecz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. 2017; 551:389-393.
Zhao Y, Mudge MC, Soll JM, Rodrigues RB, Byrum AK, Schwarzkopf EA, Bradstreet TR, Gygi SP, Edelson BT, Mosammaparast N. OTUD4 is a phospho-activated K63-deubiquitinase that regulates MyD88-dependent signaling. Molecular Cell. 2018; 69:505-516.
Carvajal DC, Byrum AK, Jackson J, Wessel S, Lemacon D, Quinet A, Tirman S, Graziano S, Ruiz M, Losada A, Cortez D, Gonzalo S, Dorsett D, Mosammaparast N, Vindigni A. Perturbing cohesin dynamics at DNA replication forks drives MRE11 nuclease-dependent replication fork slowing. Nucleic Acids Res. 2018; – June 18. [Epub ahead of print]
Soll JM, Brickner JB, Mudge MC, Mosammaparast N. Regulation of the ALKBH3-ASCC alkylation repair complex by the accessory subunit ASCC1. J. Biol Chem. – 2018; July 11. [Epub ahead of print]
Byrum AK, Carvajal DC, Mudge MC, Patel R, Sowa ME, Gygi S, Harper JW, Shi Y, Vindigni A*, Mosammaparast N*. TPX2/Aurora-A promote replication fork stability and DNA end resection via negative regulation of 53BP1. (*co-corresponding authors) J Cell Biol. – 2018; In press.

Assistant:

Jennifer Schwierjohn

Phone: (314) 362-3056

Fax: (314) 362-8888

j.schwierjohn@wustl.edu