Maxim N. Artyomov, PhD
Associate Professor, Pathology & Immunology
- Email: email@example.com
- Adjunct Professor, ITMO University, St. Petersburg, Russia
- BS, with honors: Moscow State University, Moscow, Russia (2004)
- MS: University of Chicago, Chicago, IL (2005)
- PhD: Massachusetts Institute of Technology, Cambridge, MA (2009)
Our research is on the cross-roads between experiments and theory/computation and can be characterized most succinctly as systems immunology whereby we use various methods for unbiased data generation (e.g. high-throughput next-generation sequencing) in conjunction with mathematical and statistical modeling approaches.
We focus on developing integrated experimental and computational pipelines to address important biological problems by leveraging the power of next-generation sequencing. Two major components comprise creation of such integrated pipeline: first, optimization of sequencing library preparation protocols to achieve high-throughput and cost affordability, and, second, corresponding bioinformatic processing of sequencing data and computational analysis of the high-throughput gene-expression and other kinds of sequencing data (e.g. ChipSeq, RACE etc) that allow one to gain insight into the biology in hand.
Our major interests are in the fields of Immunometabolism, Epigenetic and Transcriptional regulation associated with immune activation in the context of infectious diseases, cancer and aging.
DBBS Graduate Program Affiliation
- Immunology Program
- Computational and Systems Biology Program
- Computational and Molecular Biophysics Program
|Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN. Nature. 2018 Apr 18.|
|High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy. Gubin MM, Esaulova E, Ward JP, Malkova ON, Runci D, Wong P, Noguchi T, Arthur CD, Meng W, Alspach E, Medrano RFV, Fronick C, Fehlings M, Newell EW, Fulton RS, Sheehan KCF, Oh ST, Schreiber RD, Artyomov MN|
|Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. Cell Metab. 2016 Jul 12;24(1):158-66|
|GAM: a web-service for integrated transcriptional and metabolic network analysis. Sergushichev AA, Loboda AA, Jha AK, Vincent EE, Driggers EM, Jones RG, Pearce EJ, Artyomov MN. Nucleic Acids Res. 2016 Jul 8;44(W1):W194-200.|
|Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN. Immunity. 2015 Mar 17;42(3):419-30.|
|Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells. Artyomov MN, Munk A, Gorvel L, Korenfeld D, Cella M, Tung T, Klechevsky E. J Exp Med. 2015 May 4;212(5):743-57.|
|Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD. Nature. 2014 Nov 27;515(7528):577-81.|
|Itaconate: the poster child of metabolic reprogramming in macrophage function. O’Neill LAJ1, Artyomov MN2.|
Lab Phone: 314-286-2952
Office Location: BJC-IH Building, 8201