Immunobiology – Core Facilities

Scientific progress relies on the availability of state-of-the-art technical resources. The Division of Immunobiology runs several core facilities that provide outstanding and cost-effective service to both the basic and translational research programs.

Our FACS facility offers multi-parameter analysis allowing for rare cell populations to be studied as well as two high-speed cell sorters that are multi-parameter. Our hybridoma center has a long history of generating high quality hamster and mouse monoclonal antibodies for clients inside and outside of the institution. Furthermore, for over 20 years, our transgenic, knockout and microinjection core facility has an outstanding track record for generating genetically engineered animals at the highest levels.

Our newly formed structural biology core brings together instrumentation and services for the structural biology community from all over the School of Medicine. The division supports a nascent metabolic analysis core facility, operating 96-well and 24-well Seahorse instruments to measure oxygen consumption and extracellular acidification in culture. The division also supports imaging research with a state-of-the-art two-photon microscope maintained and operated by Dr. Bernd Zinselmeyer.

Elsewhere in the institution, a wide variety of core facilities are available and include cores for ES stem cell transfection and culture, microarray analysis, NextGen sequencing (genome, exome, target capture, RNASeq, CHIPSeq), imaging, proteomics, and viral vectors.  Many other core services are offered by specialized core facilities are run by the Siteman Cancer Center, the Diabetic Research Training Center, Digestive Disease Research Core Center, DRTC, the Hope Center for neurological disorders and the O’Brien Kidney Disease Research Center.

Learn more about all of the core facilities supported by the Department.