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Wojciech Swat, PhD

Wojciech Swat, PhD

Associate Professor, Pathology & Immunology

Additional Titles

  • Assistant Medical Director, Molecular Diagnostics Laboratory

Education

  • MS, Molecular Biology (with Honors): University of Wroclaw, Poland (1989)
  • PhD, Immunology/Genetics (Summa cum laude): Hirszfeld Institute, Wroclaw, Poland/ The Basel Institute for Immunology, Basel, Switzerland (1992)
  • Fellow, Genetics: Harvard Medical School, Boston, MA (1994-1998)
  • Fellow, Clinical Genomics: Washington University School of Medicine, St. Louis, MO (2013-2017)

Board Certifications

  • American Board of Medical Genetics (ABMGG) in Clinical Molecular Genetics

Recognition

  • Aurelia Baczko Award (for a distinguished PhD thesis in biomedical sciences), 1993
  • Howard Hughes Medical Institute Fellowship Award, 1994-97
  • Leukemia & Lymphoma Society Special Fellowship Award, 1997
  • Irvington Institute Fellowship Award, 1997
  • Hulda Irene Duggan Distinguished Investigator Award (Arthritis Foundation), 1997-2000
  • Howard Hughes Medical Institute Faculty Development Award, 2001-2003
  • American Cancer Society Award, 2002-2003
  • Leukemia & Lymphoma Society Scholar Award (5 awarded nationally), 2008-2013
  • The Kosciuszko Foundation Collegium (Distinguished Fellow), 2015

Clinical Interests

  • Clinical Molecular Genetics
  • Leukemia & Lymphoma
  • HSC Transplantation

Research Interests

Dr. Swat’s research interests are in the field of lymphocyte development and activation, signal transduction, antigen presentation, and hematopoietic malignancy. After joining the faculty ranks at Washington University School of Medicine in St. Louis, Department of Pathology and Immunology, in 2001 as a principal investigator, he ran a research lab with focus on signaling pathways mediating hematopoietic development and cancer, and was promoted with tenure in 2007. He has been distinguished as a Scholar of the Leukemia and Lymphoma Society and contributed over 100 research reports including several highly-cited publications receiving over 10,000 citations combined. Dr. Swat has trained several postdoctoral fellows and graduate students in Immunobiology and MSTP programs in his lab. He entered the Clinical Track as a Clinical Genomics fellow in 2013 and became a Fellow of the American College of Medical Genetics (ACMG) in 2017 after earning his American Board of Clinical Genetics and Genomics (ABMGG) certification in Clinical Molecular Genetics.

Publications

Pub Med Search

A protein scaffold coordinates SRC-mediated JNK activation in response to metabolic stress S Kant, CL Standen, C Morel, DY Jung, JK Kim, W Swat, RA Flavell, … Cell reports 20 (12), 2775-2783 https://www.sciencedirect.com/science/article/pii/S2211124717311324?via%3Dihub
Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming DB Graham, DG Osborne, JT Piotrowski, TS Gomez, GB Gmyrek, … PloS one 9 (6), e98606 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098606
Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL GJ Sandoval, DB Graham, GB Gmyrek, HM Akilesh, K Fujikawa, … Cancer immunology research http://cancerimmunolres.aacrjournals.org/content/early/2013/10/29/2326-6066.CIR-13-0065
Loss of DAP12 and FcRγ Drives Exaggerated IL-12 Production and CD8+ T Cell Response by CCR2+ Mo-DCs GB Gmyrek, HM Akilesh, DB Graham, A Fuchs, L Yang, MJ Miller, … PloS one 8 (10), e76145 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076145
Polarity gene discs large homolog 1 regulates the generation of memory T cells GB Gmyrek, DB Graham, GJ Sandoval, GS Blaufuss, HM Akilesh, … European journal of immunology 43 (5), 1185-1194 https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201142362
Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells GJ Sandoval, DB Graham, D Bhattacharya, BP Sleckman, RJ Xavier, … The Journal of Immunology, 1203208 http://www.jimmunol.org/content/190/6/2485
The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors W Liu, E Chen, XW Zhao, ZP Wan, YR Gao, A Davey, E Huang, L Zhang, … Sci. Signal. 5 (235), ra54-ra54 http://stke.sciencemag.org/content/5/235/ra54.full
The role of SAP97 in synaptic glutamate receptor dynamics MKA Howard, GM Elias, LAB Elias, W Swat, RA Nicoll Proceedings of the National Academy of Sciences 107 (8), 3805-3810 http://www.pnas.org/content/107/8/3805
VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans K Fujikawa, T Iwata, K Inoue, M Akahori, H Kadotani, M Fukaya, … PloS one 5 (2), e9050 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009050
 ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling DB Graham, HM Akilesh, GB Gmyrek, L Piccio, S Gilfillan, J Sim, … Blood, blood-2009-10-250415 http://www.bloodjournal.org/content/116/17/3208?sso-checked=true


Assistant:

Tammy Robison
314-362-2998
tammyrobison@wustl.edu


Lab Phone: 314-747-8886