See all

Thaddeus Stappenbeck, MD, PhD

Conan Professor, Pathology & Immunology
Professor, Developmental Biology

Fax314-362-7487

Emailstappenb@wustl.edu

Additional Titles

  • Co-Chief, Division of Laboratory and Genomic Medicine

Education

  • BA, Integrated Science Program Physiology: Northwestern University, Evanston, IL (1987)
  • MD, PhD, Medical Scientist Training Program (MSTP): Northwestern University, Evanston, IL (1995)
  • Resident, Anatomic Pathology: Washington University Medical Center, St. Louis, MO (1995-1999)
  • Clinical Fellow, Pathology: Washington University Medical Center, St. Louis, MO (1999-2000)

Board Certifications

  • American Board of Anatomic Pathology

Recognition

  • 1987 Phi Beta Kappa
  • 1992 Sigma Xi Research Award
  • 1993 Journal of Cell Science Travel Fellowship to visit laboratory of Dr. Birgit Lane
  • 1993 International Union of Pure and Applied and Biophysicists Travel Fellowship
  • 2001 Laser Capture Microdissection and Macromolecular Analysis of Normal Development and Pathology Travel Award
  • 2005 Pew Scholar
  • 2009 American Society for Clinical Investigation
  • 2010 Kavli Fellow
  • 2010 Pluto Society
  • 2012 American Gastroenterological Association (AGA) Fellowship
  • 2013 Organizer, Gastrointestinal Tract XV: Epithelia, Microbes, Inflammation and Cancer August 11-15, 2013 Steamboat Colorado (FASEB conference)
  • 2015 Chair Senior Research Awards Study Section, Crohn’s & Colitis Foundation
  • 2016 Editorial Board, Science Immunology
  • 2016 Crohn’s & Colitis Foundation Scientific Achievement in IBD Basic Science Award
  • 2017 American Association of Physicians

Clinical Interests

  • Gastrointestinal Pathology
  • Autopsy Pathology

Research Interests

I am interested in discovering key elements in the pathogenesis of inflammatory diseases in the intestine. The focus of my laboratory is host mutations and interactions with the environment that alter intestinal epithelial function. We develop and characterize novel mouse models that have mutations in genes that have susceptibility alleles in human inflammatory bowel disease. We have developed methods of injury and repair in vivo as well as epithelial culture systems whereby we can manipulate the function of specific genes and test the effects of specific environmental factors. Our overarching goal is to understand combinations of genetic and environmental factors that affect specific epithelial cell function and thus predispose individuals to develop active intestinal inflammation.

DBBS Graduate Program Affiliation

  • Immunology
  • Microbiology
  • Development Biology

Publications

pubmed search

Jain U, Lai CW, Xiong S, Goodwin VM, Lu Q, Christophi GP, VanDussen KL, Cummings BP, Young E, Hambor J, Stappenbeck TS. Temporal regulation of the bacterial metabolite deoxycholate during intestinal repair is critical for crypt regeneration (in press Cell Host Microbe)
VanDussen KL, Stojmirovic A, Li K, Liu TC, Kimes PK, Muegge BD, Simpson KF, Ciorba MA, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck TS. Small intestinal epithelial microvilli are abnormal in Crohn’s disease (in press Gastroenterology).
Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502. PubMed PMID: 28774928.
Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J. 2017 Jan 4;36(1):5-24. PubMed PMCID: PMC5210160.
Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Terrapon N, Muller A, Pudlo NA, Kitamoto S, Young VB, Henrissat B, Wilmes P, Stappenbeck TS, Nunez G, Marten EC. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell. 2016; 167(5): 1339-1353. PMCID: PMC5131798
Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS. The colonic crypt protects stem cells from microbiota-derived metabolites. Cell. 2016; 165(7): 1708:20. PMCID: PMC5026192
Stappenbeck TS, Virgin HW. Accounting for reciprocal host-microbiome interactions in experimental science. Nature. 2016; 534(7606): 191-199. PMID: 27279212
Hickey CA, Kuhn KA, Donermeyer DL, Porter NT, Jin C, Cameron EA, Jung H, Kaiko GE, Wegorzewska M. Malvin NP, Glowacki RW, Hansson, GC, Allen PM, Martens EC, Stappenbeck TS. Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 2015; 17(5): 672-80. PMCID: PMC4432250
Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS. Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation. Nature 2015; 521(7550): 90-3. PMCID: PMC4425643
Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS. Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell Host Microbe 2015; 17(1):85-97. PMCID: PMC4297260


Assistant
Ann Winn
314-454-8436
awinn@wustl.edu

Lab Phone: 314-362-4249
Office Location: CSRB, North Tower, Room 1029