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Nicholas W. Griffin, PhD

Assistant Professor, Pathology & Immunology

Phone314-362-7243

Emailnwgriffin@wustl.edu

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Education

  • BA, Biology: Whitman College, Walla Walla, WA (2002)
  • PhD, Ecology, Evolution, Population Biology: Washington University, Saint Louis, MO (2010)

Research Interests

We use a combination of metagenomics, metabolomics, immune profiling, and together with a concerted culturing initiative to disentangle the rules that govern the assembly and persistence of microbial communities in the mammalian gut and identify members of the gut microbiota that influence nutritional and metabolic health. Our group focuses this approach on studying the microbial contributions to malnutrition in children, and identifying candidate microbially-directed therapeutic strategies.

Editorial Responsibilities

Ad hoc Reviewer PLOS One
Ad hoc Reviewer Israel Journal of Ecology & Evolution

Publications

Pubmed Search

Griffin NW, Ahern PP, Cheng J, Heath AC, Ilkayeva O, Newgard CB, Fontana L, Gordon JI. Prior dietary practices and connections to a human gut microbial metacommunity alter responses to diet interventions. Cell Host Microbe, 2017 Jan;21(1):84-96.
Semenkovich NP, Planer JD, Ahern PP, Griffin NW, Lin CY, Gordon JI. Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes. Proc Natl Acad Sci USA, 2016 Dec 20;113(51):14805-14810.
Wu M, McNulty NP, Rodionov DA, Khoroshkin MS, Griffin NW, Cheng J, Latreille P, Kerstetter RA, Terrapon, Henrissat B, Osterman AL, Gordon JI. Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides. Science, 2015 Oct 2;350(6256):aac5992.
 Ussar S*, Griffin NW*, Bezy O*, Fujisaka S, Vienberg S, Softic S, Deng L, Bry L, Gordon JI, Kahn CR. Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome. Cell Metab, 2015 Sep 1;22(3):516-530. *equal contribution
Seedorf H*, Griffin NW*, Ridaura VK, Reyes A, Cheng J, Rey FE, Smith MI, Simon GM, Scheffrahn RH, Woebken D, Spormann AM, Van Treuren W, Ursell LK, Pirrung M, Robbins-Pianka A, Cantarel BL, Lombard V, Henrissat B, Knight R, Gordon JI. Bacteria from diverse habitats colonize and compete in the mouse gut. Cell, 2014 Oct 9;159(2):253-266. *equal contribution
Hsiao A, Ahmed AM, Subramanian S, Griffin NW, Drewry LL, Petri WA Jr, Haque R, Ahmed T, Gordon JI. Members of the human gut microbiota involved in recovery from Vibrio cholera infection. Nature, 2014 Nov 20;515(7527):423-426.
Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, Lyle BJ, Martini MC, Ursell LK, Clemente JC, Van Treuren W, Walters WA, Knight R, Newgard CB, Heath AC, Gordon JI. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 2013 Sep 6;341(6150):1241214.
Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature, 2011 Jun 15; 474(7351):327-336.


Lab Phone: 314-362-3963
Office Location: 4515 McKinley Research Building