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Mitchell Scott, PhD

Mitchell G. Scott, PhD

Professor, Pathology & Immunology
Co-Medical Director, Clinical Chemistry

Phone314-362-2998

Fax314-362-1461

Emailmscott@wustl.edu

Additional Titles

  • Medical Co-Director, Clinical Chemistry

Education

  • B.A., Biology: Washington University, St. Louis, MO (1974)
  • M.S., Biology: University of Missouri at St. Louis, St. Louis, MO (1977)
  • Ph.D., Immunology: Washington University School of Medicine, Dept of Microbiology and Immunology (1982)
  • Postdoctoral Fellow, Clinical Chemistry: Washington University School of Medicine, St. Louis, MO (1984)

Board Certifications

  • American Board of Clinical Chemistry, 1990

Recognition

  • 1970-1974     Tuition Scholarships and Dean’s list, University of Kansas, Lawrence, Kansas, and Washington University, St. Louis, MO
  •  1977-1980     NIH-doctoral training grant
  •  1980-1982     Dept. of Microbiology and Immunology, Stephen I. Morse Fellowship in Immunology
  •  1986     Mallinckrodt R&D Special Achievement Award
  •  2000     American Association for Clinical Chemistry Award for Outstanding Contributions in Education
  • 2010     Trans-Atlantic Lectureship Award, Association for Clinical Biochemistry (UK).

Clinical Interests

  • Clinical Chemistry

Research Interests

  • Cardiac Biomarkers
  • Glucose Monitoring
  • Biologic Variability of Biomarkers
  • Clinical Trials of Biomarkers
  • General Clinical Chemistry

Editorial Responsibilities

2006 – Present Associate Editor Clinical Chemistry
2000 – 2004 Associate Editor Clinical Chemistry
1998 – 2000 Editorial Board Clin Chim Acta
1997 – 2000 Editorial Board Clinical Chemistry

Service to the Department

Present Coursemaster, 2nd Year Pathology Laboratory Medicine Course
Present Coursemaster, 3rd and 4th Year Laboratory Medicine Clerkships

Service to the University

2005 – Present BJC Center for Clinical Excellence Council of Clinical Experts in Laboratory Medicine

Publications

Pub Med Search

Schindler EI, Szymanski JJ, Hock KG, Geltman EM, Scott MG: Short- and long-term biologic variability of Galectin-3 and other cardiac biomarkers in patients with stable heart failure and healthy adults. Clin Chem. 2016 Feb;62(2):360-6.
Szymanski JJ, Otrock ZK, Patel K, Scott MG: Incidence of humoral hypercalcemia of malignancy among hypercalcemic patients with cancer. Clin Chim Acta. 2016 Jan;453:190-3.
Wilen CB, Szymanski JJ, Hung S, Rajan A, Lavigne PM, Char DM, Geltman EM, Scott MG. Impact on patient management and outcome of switching between 2 contemporary sensitive cardiac troponin assays. Clin Chem 2015;61:870-876.
Scott MG.  The Evolution of Accuracy Requirements for Glucose Meters: How We Got to the Recent FDA Draft Guidances (Editorial).  Point of Care 2014;13:79-81.
Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. High-sensitivity cardiac Troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after non-cardiac surgery.  Am Heart J 2013;166:325-332.
Mitsios JV, Ashby LA, Haverstick DM, Bruns DE, Scott MG.  ­Analytic evaluation of a new glucose meter system in 15 different critical care settings.  J Diab Tech Sci 2013;7:1282-87.
Scott MG, Ashwood ER, Annesley TM, Leonard DG, Burgess MC. FDA oversight of laboratory-developed tests: Is it necessary, and how would it impact clinical laboratories? Clin Chem 2013;59:1017-22.
Finfer S, Wernerman J, Preiser J-C, Cass T, Desaive T, Hovorka, Joseph JI, Kosiborod M, Krinsley J, Mackenzie I, Mesotten D, Schulz M, Scott MG, Slingerland R, Van den Berghe G and Van Herpe T.  Consensus recommendations on “measurement of blood glucose and reporting glycemic control in critically ill adults.  Critical Care 2013;17:229-40.
Scott MG, Smith BR, Wu AH, Young IS, Plebani, M Chiu RW. How well are we training the next    generation of clinical pathologists and clinical laboratory directors? A global perspective. Clin Chem 2012;58:491-5.
Deetz CO, Nolan DK, Scott MG.  An examination of the utility of repeat testing practices in a large hospital clinical chemistry laboratory. Am J Clin Path 2012;137:20-25.
 Miller WG Erek A, Cunningham TD, Oladipo OO, Scott MG, Johnson RE. Commutability limitations influence quality control results with different reagent lots.  Clin Chem 2011;57:76–83.
 Dallas J, Brown SM, Hock K, Scott MG, Skrupky LP, Boyle III WA, Kollef MH.  Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the ICU setting.  Respiratory Care 2010;56:412-19.
 Gronowski AM, Cervinski MA, Stenman UH, Woodworth A, Ashby L, Scott MG. False Negative Results in Point-of-care Qualitative hCG Devices Due to Excess hCG Beta Core Fragment. Clin Chem 2009; 55:1389–94.
 Scott MG, Bruns DE, Boyd JA, Sacks DB. Tight Glucose Control in the Intensive Care Unit: Are Glucose Meters up to the Task? Clin Chem 2009 55:18-20.
 Scott MG, Bruns DE, Sacks DB.  Tight glycemic control in critically ill adults.  JAMA 2008;300:2725-26 (letter).
 Ford BA, Coyne DW, Eby CS, Scott MG. Variability of ferritin measurements in chronic kidney disease; implications for iron management.  Kidney International 2009;75:104-110. (published online 08 Oct 2008, doi: 10.1038/ki.2008.526)
Scott MG, Bruns DE.  Improving training in Laboratory Medicine (Editorial).  Clin Chem 2006;52:915-916.
 Apple FS, Murakami MM, Christenson RH, Campbell JL, Miller CJ, Hock KG, Scott MG.  Analytical performance of the iSTAT cardiac troponin I assay.  Clin Chim Acta 2005;345:123-127.
 Haymond S, Cariappa R, Eby CS, Scott MG.  Laboratory assessment of oxygenation in methemoglobinemia.  Clin Chem 2005;51:434-444.
 Kim WJ, Laterza OF, Hock KG, Pierson-Perry JF, Kaminski DM, Mesguich M, Braconnier F, Zimmermann R, Zaninotto M, Plebani M, Hanna A, Cembrowski GS, Scott MG.  Performance of a revised cardiac troponin method that minimizes interferences from heterophilic antibodies.  Clin Chem 2002;48:1028-1034
 Laterza OF, Price CP, Scott MG.  Cystatin C:  An improved estimation of glomerular filtration rate?  Clin Chem 2002;48:699-707.
Uhlmann EJ, Hock KG, Issitt C, Sneeringer MR, Cervelli DR, Gorman RT, Scott MG. Reference intervals for plasma cystatin C in healthy volunteers and renal patients, as measured by the Dade Behring BN II System, and correlation with creatinine..  Clin Chem 2001;47:2031-2033.
 Johnson L, Doherty G, Lairmore T, Moley JF, Brunt LM, Koenig J, Scott MG. Evaluation of the performance and clinical impact of a rapid intraoperative PTH assay in conjunction with preoperative imaging and concise parathyroidectomy.  Clin Chem 2001;47:919-925.
 Bruns DE, Ladenson JH, Scott MG. Hyponatremia (letter). New Engl J Med 2000;343:886-7.
 Covinsky M, Laterza O, Pfeifer JD, Farkas-Szallasi T, Scott MG. An IgMl antibody to Escherischia coli is the cause of false positive results in several commercial immunometric assays.  Clin Chem 2000;46:1157-61.
 Chen D, Crimmins DL, Hsu FF, Lindberg F, Scott MG.  Hemoglobin Raleigh as the cause of a falsely increased HbA1C by ion-exchange HPLC.  Clin Chem 1998;44:1296-1301.
 Karon BS, Daly T, Scott MG. Mechanisms of dopamine and dobutamine interference in biochemical tests using peroxide and peroxidase to generate chromophore. Clin Chem 1998;44:155-160.
Mast AE, Blinder MA, Gronowski A, Chumley C, Scott MG.  Clinical utility of the serum transferrin receptor level in the evaluation of iron deficiency anemia.  Clin Chem 1998;44:45-51.
 Parvin CS, Lo SF, Deuser SM, Weaver LG, Lewis LM, Scott MG.  Impact of Point-Of-Care Testing on patient length of stay in a large emergency department.  Clin Chem 1996; 42:711-717.
 Scott MG, Crimmins DL, McCourt DW, Chung G, Schable KF, Thiebe R, Quenzel EM, Zachau HZ,  Nahm MH.  Clonal characterization of the human IgG antibody repertoire to H. influenzae type b polysaccharide.  IV.  The less frequently expressed VL are heterogeneous.  J Immunol 1991;147:4007-13.
 Scott MG, Crimmins DL, McCourt DC, Zocher I, Theibe R, Zachau HG, Nahm MH.  Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide.  III. The most common VL is the product of a single VII gene  and one of several J genes joined by an invariant arginine.  J Immunol 1989;143:4110-6.
Scott MG, Tarrand JJ, Crimmins DL, McCourt DW, Sigel N, Smith C, Nahm ­MH.  Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. II.  IgG antibodies contain VH genes from a single VH family and VL genes from at least four VL families.  J Immunol 1989;143:293-8.
 Scott MG, Crimmins DL, McCourt D, Tarrand JJ, Eyerman, ME, Nahm MH.  A simple in situ cyanogen bromide cleavage method to obtain internal amino acid sequence of proteins electroblotted to PVDF membranes.  Biochem Biophys Res Comm 1988;155:1353-9.
 Scott MG, Hoffman J, Meltzer V, Siegfried B, Chan KM.  Comparison of effects of uremia on the boronate affinity and ion exchange methods of determining glycosylated hemoglobins. Clin Chem 1984;30:896-8.


Lab Phone: 314-362-1475
Office Location: BJC-IH Building, Room 4420