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Michael J Barratt, PhD

Instructor, Pathology and Immunology

Phone314-747-6010

Emailmjbarratt@wustl.edu

Additional Titles

  • Program Director, Breast Milk, gut Microbiome, and Immunity (BMMI) Project
  • Executive Director, Center for Gut Microbiome and Nutrition Research

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Education

  • BA (Hons): Exeter College, Oxford University, UK (1990)
  • MA: Exeter College, Oxford University, UK (1992)
  • PhD: Kings College London, UK (1994)

Recognition

  • Tadion-Rideal Prize for Molecular Science, Kings College London UK
  • BDH Prize for Biochemistry, Oxford University
  • Quarrel Read Prize, Oxford University

Research Interests

Michael Barratt is Executive Director of the Center for Gut Microbiome and Nutrition Research at Washington University in St. Louis, and a member the laboratory of Jeffrey Gordon where he serves as Program Director of the Breast Milk Gut Microbiome and Immunity (BMMI) Project. He is currently working with investigators at the International Center for Diarrheal Disease Research in Bangladesh (icddr,b) to test the effectiveness of microbiota-directed foods in repairing gut microbiota immaturity in malnourished children. He brings to this role a background in pharmaceutical and consumer healthcare R&D, having spent 17 years in a variety of scientific leadership roles in preclinical and early clinical research and development spanning multiple areas including dermatology, cardiovascular disease, neuroscience, anti-bacterials and inflammation/immunology. Among other positions, he was Head of Molecular Pharmacology for Pfizer R&D at Ann Arbor, MI and a member of the Research and Biology Leadership teams. He has led a variety of Discovery Projects and contributed to bringing more than 15 drug candidates into clinical development. Prior to joining the Gordon Lab, he served as External Alliance Lead for Pfizer’s Global Indications Discovery Unit, a group focused on establishing collaborations to identify new uses for shelved compounds and existing drugs. He is also co-editor of the first book to be written on drug repositioning.

Editorial Responsibilities

2014-2015 Editor Drug Repurposing, Rescue and Repositioning

 

Publications

Blanton LV, Barratt MJ, Charbonneau MR, Ahmed T, Gordon JI. Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics. Science. 2016 Jun 24;352(6293):1533. doi: 10.1126/science.aad9359. Review. PMID: 27339978
Charbonneau MR, O’Donnell D, Blanton LV, Totten SM, Davis JC, Barratt MJ, Cheng J, Guruge J, Talcott M, Bain JR, Muehlbauer MJ, Ilkayeva O, Wu C, Struckmeyer T, Barile D, Mangani C, Jorgensen J, Fan YM, Maleta K, Dewey KG, Ashorn P, Newgard CB, Lebrilla C, Mills DA, Gordon JI. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.Cell. 2016 Feb 25;164(5):859-71. doi: 10.1016/j.cell.2016.01.024. PMID:26898329
Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, Subramanian S, Manary MJ, Trehan I, Jorgensen JM, Fan YM, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, Maleta KM, Newgard CB, Ashorn P, Dewey KG, Gordon JI. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science. 2016 Feb 19;351(6275). pii: aad3311. doi: 10.1126/science.aad3311. PMID:26912898
Subramanian S, Huq S, Yatsunenko T, Haque R, Mahfuz M, Alam MA, Benezra A, DeStefano J, Meier MF, Muegge BD, Barratt MJ, VanArendonk LG, Zhang Q, Province MA, Petri WA Jr, Ahmed T, Gordon JI. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature. 2014 Jun 19;510(7505):417-21. doi: 10.1038/nature13421. PMID: 24896187
Barratt M.J. & Frail D. (2012). Editors. Drug Repositioning: Bringing New Life to Shelved Assets & Existing Drugs. John Wiley & Sons Inc., Hoboken, New Jersey.
Barratt, M.J., Frail, D. (2012). Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs. In Barratt, M.J. & Frail D. (Eds.), Drug Repositioning Bringing New Life to Shelved Assets & Existing Drugs. (pp. 33-51). John Wiley & Sons Inc., Hoboken, New Jersey.


Assistant
Stephanie Amen
314-362-0269
samen@wustl.edu

Lab phone: 314-747-6010
Office Location: 4515 McKinley Ave, Room 4213