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Ki-Wook Kim, PhD

Instructor, Pathology & Immunology

Phone203-909-0787

Emailkiwook.kim@wustl.edu

Education

  • Bs.c.: Handong University, Pohang, South Korea (2004)
  • Ms.c.: Handong University, Pohang, South Korea (2006)
  • PhD: Weizmann Institute of Science, Rehovot, Israel (2011)

Research Interests

Macrophages, dendritic cells and monocytes consist of mononuclear phagocytes systems (MPS). Macrophages can be divided by their origins or functions; Embrynoically derived macrophages from yolk-sac (microglia) or fetal-liver (peripheral tissue macrophages) and bone marrow HSC-derived macrophages. Functionally, macrophages induces inflammation by secreting pro-inflammatory cytokines such as IL-1b, IL6 in early stage of infection or injury. In resolving stages, macrophages cures the wound/infected tissue by secreting anti-inflammtory cytokines such as TGF-b and IL-10. I am interested in the origin and function of macrophages in visceral tissues including peritoneal/pleural cavities. Through the lineage tracing approach such as fate-mapping and parabiosis experiment, we could track the origin and their development of macrophages in peripheral tissues (Yona, Kim and Wolf et.al, 2013 Immunity). In peritoneal- and pleural cavities, there are two distinct macrophage populations: F4/80+ macrophages and MHCII+ macrophage in steady state. We recently reported MHCII+ macrophages originate from circulating Ly6C+ monocytes after birth by fate-mapping, parabiosis approaches and adoptive monocyte transfer. These macrophages are dependent on IRF4 as resident macrophages (Kim et.al. 2016 JEM). Currently, we study on the function of peritoneal/pleural MHCII+ macrophages as well as other visceral tissue resident macrophages in steady state and a pathogenic condition.

Publications

  1. Wolf Y, Shemer A, Polonsky M, Gross M, Mildner A, Yona, S, David E, Kim K-W, Goldmann T, Amid I, Heikenwalder M, Nedospasov S, Prinz M, Friedman N, Jung. S “ Autonomous TNF is Critical for Monocytes Survival in Steady State and Inflammation in vivo” (2017) Journal of Experimental Medicine (JEM), In Press
  2. Wu X, Briseno CG, Durai V, Albring JC, Haldar M, Bagadia P, Kim K-W, Randolph GJ, Murphy TL and Murphy KM. “ Mafb Lineage Tracing to Distinguish Macrophages from Other Immune Lineages Reveals Dual Identity of Langerhans Cells” (2016) Journal of Experimental Medicine (JEM) 213(12); 2553-2565
  3. Kim K-W, Zhang N, Choi K, Randolph GJ. “Homegrown Macrophages.” (2016) Immunity, 45(3); 468-470
  4. Kim K-W, Williams J, Wang YT, Ivanov S, Gilfillan S, Colonna M, Virgin HW, Gautier EL, Randolph GJ. “The MHCII+ Resident Peritoneal and Pleural Macrophage Subset Relies upon IRF4 for Development from Circulating Monocytes.” (2016) Journal of Experimental Medicine (JEM), 213(10); 1951-1959
  5. Ivanov S*, Scallan J*, Kim K-W, Werth K, Johnson M, Saunders B, Wang P, Kuan E, Straub A, Ouhachi M, Weinstein E, Williams J, Briseno, C, Colonna, M, Isakson B, Gautier E, Forster R, Davis M, Zinselmeyer B, Randolph GJ. “Regulation of Lymphatic Collecting Vessel Permeability by CCR7 and IRF4-dependent Dendritic Cells” (2016) Journal of Clinical Investigation (JCI). 126(4); 1581-1591, * equal contribution
  6. Aychek T, Mildner A, Yona S, Kim K-W, Lampl N, Reich-Zeliger S, Boon L, Yogev N, Waisman A, Cua D.J and Jung S “IL-23-mediated Mononuclear Phagocyte Crosstalk Protects Mice from Citrobacter rodentium-induced Colon Immunopathology” (2015) Nature Communications (Nat. Comm) (6); 6525
  7. Lee S, Guixiang X, Jay T, Bhatta S, Kim K-W, Jung S, Gary L, Ransohoff RM, and Lamb B “Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway,” (2014) Journal of Neuroscience. 34(37); 12538-46
  8. Kim K-W, Yang SH, Kim JB, “Protein Fractions from Korean Mistletoe (Viscum Album Coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells,” (2014) Evid Based Complement Alternat Med. 703624
  9. Zigmond E, Bernshtein B, Friedlander G, Walker C, Yona S, Kim K-W, Brenner O, Krauthgamer R, Varol C, Muller W, Jung S, “Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis,” (2014) Immunity; 40(5) 720-733
  10. Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim K-W, Mogg AJ, Perretti M,
  11. Malcangio M, “Monocyte Expressing CX3CR1 Orchestrate the Development of Vincristine-induced Pain,” (2014) Journal of Clinical. Investigation. (JCI); 124(5) 2023-2036
  12. Yona S*, Kim K-W*, Wolf Y*, Mildner A, Varol D, Breker M, Strauss-Ayali D, Viukov S, Guklliams M, Misharin A, Hume DA, Perlman H, Malissen B, Zelzer E, Jung S, “Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis,” (2013) Immunity 38(1); 79- 91. * equal contribution
  13. Farache J, Koren I, Milo I, Gurevich I, Kim K-W, Zigmond E, Furtado G, Lira S, Shakhar G, “Luminal Bacteria Recruits CD103+ Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentations,” (2013) Immunity 38(3); 581-595
  14. Shechter R, Miler O, Yovel G, Rosenzweig N, Rist J. London A, Kim K-W, Klein E, Kalchenko V, Bendel P, Lira S, Jung S, Schwartz M, “Recruitment of beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by the Remote Brain Choroid Plexus,” (2013) Immunity 38(3); 555-569
  15. Wolf Y, Yona S, Kim K-W, Jung S, “Microglia, Seen from the CX3CR1 Angle,” (2013) Frontiers in Cellular Neuroscience 1013; 129-144
  16. Mildner A, Chapnik E, Manor O, Yona S, Kim K-W, Aychek T, Varol D, Beck G, Itzhaki Z, Amit I, Hornstein E, Jung S, “Mononuclear Phagocyte MicroRNome Analysis Identifies miR-142 as Critical Regulator of Murine Dendritic Cell Homoeostasis,” (2013) Blood 121; 1016-1027
  17. Kim K-W, Farache J, Vallon-Eberhard A, Shezen E, Ludwig A, Lira S, Shakhar G, Jung S, “In-vivo Structure/ Function and in vivo Expression Analysis of the CX3CL1 Chemokine, Fractalkine,” (2011) Blood 118; e156-167
  18. Bar-on L, Birnberg T, Kim K-W, Jung S, “Dendritic cell-restricted CD80/86 Deficiency Results in Peripheral T Regulatory Cell Impairment but is not Associated with Lymphoycte Hyperactivation,” (2011) The European Journal of Immunology (EJI) 41(2); 291-298
  19. Landsman L, Bar-on L, Zernecke A, Kim K-W, Krauthgamer R, Shagdarsuren E, Lira S-A, Weismann I, Weber C, Jung S, “CX3CR1 is Required for Monocyte Homeostasis and Atherogenesis by Promoting Cell Survival,” (2009) Blood 113; 963- 972


Lab Phone: 314-286-2345
Office Location: BJC-IH Building, Room 8345