See all

Kelli L VanDussen, PhD

Instructor, Pathology & Immunology

Phone314-362-8422

Emailkvandussen@wustl.edu

Related Links

Education

  • BS, Biomedical Science: Grand Valley State University, Allendale, MI (2004)
  • PhD, Molecular & Integrative Physiology: University of Michigan, Ann Arbor, MI (2010)

Recognition

  • 2007 American Gastroenterological Association Foundation Graduate Student Research Fellowship Award
  • 2008 Outstanding Graduate Student Teaching and Service Award, University of Michigan Medical School, Ann Arbor, MI
  • 2009 Horace W. Davenport Research Award, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI
  • 2009 Rackham Pre-doctoral Fellowship, University of Michigan
  • 2014 Crohn’s and Colitis Foundation of America Research Fellow

Research Interests

My research is aimed towards understanding the role of intestinal epithelial cells during health and disease, with a focus on the inflammatory bowel diseases. These epithelial cells form a single cell layer that lines the intestinal tract, forming a borderline between the contents of the intestinal lumen and the supporting cells of the parenchyma. Their functions are diverse and include digestion and absorption of nutrients, formation of physical and secreted barriers that separate the host from the resident microbiome and transient pathogens, and communication with the innate and adaptive components of the immune system. I utilize in vivo and in vitro models as well as clinical tissue samples in my studies.

Publications

PubMed Search

Miyoshi H*, VanDussen KL*, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J 2017: 36(1):5-24. PMCID: PMC5210160 *Authors contributed equally.
Demitrack ES, Gifford GB, Keeley TM, Carulli AJ, VanDussen KL, Thomas D, Giordano TJ, Liu Z, Kopan R, Samuelson LC. Notch signaling regulates gastric antral LGR5 stem cell function. EMBO J 2015: 34(20):2522-36. PMCID: PMC4609184
VanDussen KL, Marinshaw JM, Shaikh N, Miyoshi H, Moon C, Tarr PI, Ciorba MA†, Stappenbeck TS†. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut 2015: 64(6):911-20. PMCID: PMC4305344 †Authors contributed equally.
Tsai YH*, VanDussen KL*, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 Regulates Notch Function in Intestinal Stem Cells of Mice. Gastroenterology 2014: 147(4):822-834. PMCID: PMC4176890 *Authors contributed equally.
Moon C, VanDussen KL, Miyoshi H, Stappenbeck TS. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunol 2014: 7(4):818-28. PMCID: PMC4019725
VanDussen KL*, Liu TC*, Li D, Towfic F, Modiano N, Winter R, Haritunians T, Taylor KD, Dhall D, Targan SR, Xavier RJ, McGovern DP, Stappenbeck TS. Genetic variants synthesize to produce Paneth cell phenotypes that define subtypes of Crohn’s disease. Gastroenterology 2014: 146(1):200-9. PMCID: PMC3899786   *Authors contributed equally.
VanDussen KL, Carulli A, Keeley TK, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud Å, Grosse A, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ and Samuelson LC. Notch Signaling Modulates Proliferation and Differentiation of Intestinal Crypt Base Columnar Stem Cells. Development 2012: 139(3):488-97. PMCID: PMC3252352
VanDussen KL and Samuelson LC. Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Developmental Biology 2010:346(2):215-23. PMCID: PMC2945455
Lopez-Diaz L, Jain R, Keeley TM, VanDussen KL, Brunkan CS, Gumucio D, Samuelson LC. Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate. Developmental Biology 2007: 309:298-305. PMCID: PMC2679162


Lab Phone: 314-362-4249
Office Location: CSRB-NTA, Room 1030