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John W Turk, MD

Professor, Medicine

Phone314 362-2602

Emailjturk@wustl.edu

Additional Titles

  • Professor, Pathology & Immunology
  • Alan and Edith Wolff Professor in Endocrinology
  • Director, Medicine Dept. Mass Spectrometry Facility 8 SW Tower

Related Links

Education

  • AB, Summa Cum Laude: Washington University, St. Louis, MO (1970)
  • MD, PhD: Washington University, St. Louis, MO (1976)
  • Intern in Internal Medicine: University of Chicago (1977)
  • Resident in Laboratory and Genomic Medicine: Washington University, St. Louis, MO (1978)
  • Resident in Internal Medicine: Washington University, St. Louis, MO (1980)
  • Fellow in Clinical Pharmacology: Vanderbilt University (1982)

Recognition

  • Career Development Award, Pharmaceutical Manufacturer’s Association, 1983-1985
  • Research Career Development Award, National Institutes of Health, 1987-1992
  • Elected to American Society for Clinical Investigation honor society, 1991
  • Study Section Membership, Medical Biochemistry, National Institutes of Health, 1992-96
  • MERIT Award, National Institutes of Health, 1993-2001
  • Elected to Association of American Physicians honor society, 2001
  • MERIT Award, National Institutes of Health, 2001-2011
  • Appointed to the Editorial Board, Journal of Biological Chemistry, 2007-2012
  • Appointed to External Evaluation Committee, National Institutes of Health Common Fund Metabolomics Program, 2013-2016
  • Appointed to second term, Editorial Board, Journal of Biological Chemistry 2014-2019
  • Installed as Alan A. and Edith L. Wolff Professor in Endocrinology, Washington Univ. School of Medicine, 2014

Research Interests

Phospholipase A2 in Pancreatic Islet Beta Cell Biology

Mass Spectrometry of Complex Lipids

Editorial Responsibilities

2007-2012 and 2014-2019 Editorial Board J. Biol. Chem.
1993-1996 Editorial Board Diabetes

Service to the Department

1982-Present Director of Drug Analysis and Toxicology

Publications

Click to view all publications

Original Manuscripts

  1. Turk J, Panse G, & Marshall G: Resolution and amino protection of alpha-methyl amino acids. J. Organ. Chem. 1975; 40: 953-955. PMID: 1133638
  2. Turk J & Marshall G: Alpha-methyl substrates of Carboxypeptidase A. A steric probe of the active site. Biochemistry 1975; 14: 2631-2635. PMID: 1148172
  3. Turk J, Needleman P, & Marshall G: Alkylating analogs of bradykinin. J. Med. Chem. 1975; 18: 1135-1139. PMID: 240938
  4. Turk J, Needleman P, & Marshall G: Analogs of bradykinin with restricted conformational freedom. J. Med. Chem. 1975; 18: 1139-1142. PMID: 1236952
  5. Turk J, Needleman P, & Marshall G: Analogs of angiotensin II with restricted conformational freedom including a new antagonist. Molecular Pharmacology. 1976; 12: 217-224. PMID: 1264066
  6. Turk J, Weiss S, Davis J, & Needleman P: Fluorescent derivatives of prostaglandins and thromboxanes for liquid chromatography. Prostaglandins 1978; 16: 291-309. PMID: 704934
  7. Weiss S, Turk J, & Needleman P: A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase. Blood 1979; 53: 1191-1196. PMID: 376000
  8. Turk J, Wyche A, & Needleman P: Inactivation of vascular prostacyclin synthetase by platelet lipoxygenase products. Biochem. Biophys. Res. Commun. 1980; 95: 1628-1634. PMID: 6774728
  9. Turk J, Maas R, Brash A, Roberts L, & Oates J: Arachidonic acid 15-lipoxygenase products from human eosinophils. J. Biol. Chem. 1982; 257: 7068-7076. PMID: 6806264
  10. Maas R, Turk J, Oates J, & Brash A: Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation by rat and human leukocytes. J. Biol. Chem. 1982; 257: 7056-7067. PMID: 6806263
  11. Rand T, Turk J, Maas R, & Colley D: Arachidonic acid metabolism in the murine eosinophil. Influence of lipoxygenase products on the migration response to the lymphokine eosinophil stimulation promoter. J. Immunol. 1982; 129: 1239-1242. PMID: 6286759
  12. Roberts L, Turk J, & Oates J: Shock syndrome associated with mastocytosis: Pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks. Adv. Shock Res. 1982; 8: 145-152. PMID: 7136941
  13. Turk J, Rand T, Maas R, Lawson J, Brash A, Roberts L, & Oates J: Identification of lipoxygenase products of arachidonic acid metabolism in stimulated murine eosinophils. Biochim. Biophys. Acta. 1983; 750: 78-90. PMID: 6402030
  14. Turk J, Henderson W, Klebanoff S, & Hubbard W: Iodination of arachidonic acid mediated by eosinophil peroxidase, myeloperoxidase, and lactoperoxidase: Identification and comparison of products. Biochim. Biophys. Acta. 1983; 751: 189-200. PMID: 6299368
  15. Turk J, Oates JA, & Roberts L: Intervention with epinephrine in hypotension associated with mastocytosis. J. All. Clin. Immunol. 1983; 71: 189-192. PMID: 6296213
  16. Turk J, Colca J, Kotagal N. & McDaniel ML: Arachidonic acid metabolism in isolated pancreatic islets I. Identification and quantitation of lipoxygenase and cyclooxygenase products. Biochim. Biophys. Acta 1984; 794: 110-124. PMID: 6329307
  17. Turk J, Colca J, Kotagal N, & McDaniel ML: Arachidonic acid metabolism in isolated pancreatic islets II. The influence of glucose and of inhibitors of arachidonate metabolism on insulin secretion and metabolite synthesis. Biochim. Biophys. Acta. 1984; 794: 125-136. PMID: 6428455
  18. Turk J, Colca J, & McDaniel ML: Arachidonic acid metabolism in isolated pancreatic islets III. Effects of exogenous lipoxygenase products and inhibitors on insulin secretion. Biochim. Biophys. Acta 1985; 834: 23-36. PMID: 3919770
  19. Turk J, Wolf, B, Comens P, Colca J, Jakschik B, & McDaniel ML: Arachidonic acid metabolism in isolated pancreatic islets IV. Negative ion-mass spectrometric quantitation of monooxygenase product synthesis by liver and islets. Biochim. Biophys. Acta 1985; 835: 1-17. PMID: 3924104
  20. Wolf B, Turk J, Sherman W, & McDaniel ML: Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-triphosphate in isolated pancreatic islets. Biol. Chem. 1986; 261: 3501-3510. PMID: 3081507
  21. Turk J, Wolf B, & McDaniel ML: Measurement of subnanogram quantities of arachidonic acid from isolated pancreatic islets by negative ion mass spectrometry. Biol. Chem. 1986; 261: 3510-3511. PMID: 3081507
  22. Turk J, Wolf BA, Lefkowith JB, Stump WT, & McDaniel ML: Glucose-induced phospholipid hydrolysis in isolated pancreatic islets. Quantitative effects on the phospholipid content of arachidonate and other fatty acids. Biochim. Biophys. Acta 1986; 879: 399-409. PMID: 3535899
  23. Turk J, Wolf B, & McDaniel M: Quantitation of myo-inositol as the hexakis (trifluoroacetyl) derivative with negative ion-chemical ionization mass spectrometry. Biomed. Env. Mass Spec. 1986; 13: 237-244. PMID: 2941090
  24. Turk J, Wolf BA, & McDaniel ML: Glucose-induced accumulation of inositol-tris-phosphates in isolated pancreatic islets. Predominance of the 1,3,4-isomer. Biochem J. 1986; 237: 259-263. PMID: 3541896
  25. Wolf BA, Colca JR, Comens PG, Turk J, & McDaniel ML: Glucose-6-phosphate regulates Ca2+ steady-state in endoplasmic reticulum of islets. A possible link in glucose-induced insulin secretion. J. Biol. Chem. 1986; 261: 16284-16287. PMID: 3023346
  26. Mangino M, Anderson C, DeSchryver K, Tyler J, Sicard G, & Turk J: Eicosanoid synthesis associated with renal allograft rejection. Transplant. Proc. 1986; 18: 63-70.
  27. Mangino MJ, Anderson CB, DeSchryver K, Tyler JD, Sicard GA, & Turk J: Arachidonic acid metabolism and renal allograft rejection. Transplant. Proc. 1987; 19: 444-445. PMID: 3274801
  28. Mangino M, Anderson C, DeSchryver K, & Turk J: Arachidonate lipoxygenase products and renal allograft rejection in dogs. Transplantation 1987; 44: 805-808. PMID: 2827351
  29. Chan KM & Turk J: Mechanism of arachidonic acid-induced Ca2+ mobilization from rat liver microsomes. Biochim. Biophys. Acta 1987; 928: 186-193. PMID: 3105593
  30. Foegh ML, Lim K, Douglas F, Turk J, Helfrich GB, Taher SA, & Alijani MR: Differential effect of CGS 13080, a thromboxane synthase inhibitor, in suppressing serum and urine immunoreactive thromboxane B2 in kidney transplant patients. Transplant. Proc. 1988; 20: 424-427. PMID: 3279631
  31. Wolf BA, Florholmen J, Turk J, & McDaniel ML: Studies of the Ca2+ requirements for glucose and carbachol-induced augmentation of inositol trisphosphate and inositol tetrakisphosphate accumulation in digitonin-permeabilized islets. Evidence for a glucose recognition site in insulin secretion. J. Biol. Chem. 1988; 263: 3565-3575. PMID: 2831191
  32. Turk J, Hughes JH, Easom RA, Wolf BA, Scharp DW, Lacy PE, & McDaniel ML: Arachidonic acid metabolism and insulin secretion by isolated human pancreatic islets. Diabetes 1988; 37: 992-996. PMID: 3133262
  33. Turk J, Stump WT, Wolf BA, Easom RA, & McDaniel ML: Quantitative stereochemical analysis of subnanogram amounts of 12-hydroxy-(5,8,10,14)-eicosatetraenoic acid by sequential chiral phase liquid chromatography and stable isotope dilution mass spectrometry. Anal. Biochem. 1988; 174: 580-588. PMID: 3071179
  34. Holtzman MJ, Hansbrough JR, Rosen GD, & Turk J: Uptake, release, and novel species-dependent oxygenation of arachidonic acid in human and animal airway epithelial cells. Biochim. Biophys. Acta 1988; 963: 401-413. PMID: 2848586
  35. Wolf BA, Colca J, Turk J, Florholmen J, & McDaniel ML: Regulation of Ca2+ homeostasis by the islet endoplasmic reticulum and its role in insulin secretion. Am. J. Physiol. 1988; 254: E121-E136. PMID: 3279798
  36. McDaniel ML, Hughes JH, Wolf BA, Easom RH, & Turk J: A role for interleukin-1 in insulin secretion. Descriptive and mechanistic considerations. Diabetes 1988; 37: 1311-1315. PMID: 3046964
  37. Turk J, Wolf BA, Easom RA, Hughes JH, & McDaniel ML: Arachidonic acid metabolism in isolated pancreatic islets V. The enantiomeric composition of 12-hydroxy-(5,8,10,14)-eicosatetraenoic acid indicates synthesis by a 12-lipoxygenase rather than a monooxygenase. Biochim. Biophys. Acta 1989; 1001: 16-24. PMID: 2492199
  38. Wolf BA, Easom R, Hughes J, McDaniel ML, & Turk J: Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation. Biochemistry 1989; 28: 4291-4301. PMID: 2504278
  39. Wolf BA, Hughes JH, Florholmen J, Turk J, & McDaniel ML: Interleukin-1 inhibits glucose-induced Ca2+ uptake in Islets of Langerhans. FEBS Lett. 1989; 248: 35-38. PMID: 2656294
  40. Mangino ML, Anderson CB, Murphy MK, & Turk J: Arachidonate metabolism associated with intestinal ischemia-reperfusion injury. Am. J. Physiol. 1989; 257: G299-G307. PMID: 2504053
  41. Hansbrough JR, Atlas AB, Turk J, & Holtzman MJ: Arachidonate 12-lipoxygenase and cyclooxygenase:PGE isomerase are predominant pathways for oxygenation in bovine tracheal epithelial cells. Am. J. Respir. Cell Mol. Biol. 1989; 1: 237-244. PMID: 2516452
  42. Hughes JH, Easom RA, Wolf BA, Turk J, & McDaniel ML: Interleukin 1-induced accumulation of prostaglandin E2 in isolated pancreatic islets. Diabetes 1989; 38: 1251-1257. PMID: 2507377
  43. Holtzman MJ, Turk J, & Pentland A: A regiospecific monooxygenase with novel stereo-preference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells. J. Clin. Invest. 1989; 84: 1446-1453. PMID: 2509517
  44. Easom RA, Hughes JH, Landt M, Wolf BA, Turk J, & McDaniel ML: Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets. Biochem. J. 1989; 264: 27-33. PMID: 2690823
  45. Wolf BA, Daft M, Koenig J, Flye MW, Turk J, & Scott MG: Measurement of cyclosporine concentrations in whole blood. Comparison of HPLC with radioimmunoassays using a specific monoclonal antibody and [3H]- or [125I]-labeled ligand. Clin. Chem. 1989; 35: 120-124. PMID: 2642760
  46. Wolf BA, Easom R, McDaniel ML, & Turk J: Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rodents and humans. Clin. Invest. 1990; 85: 482-490. PMID: 2405021
  47. Wolf BA, Conrad-Kessel W, & Turk J: Long chain fatty alcohol quantitation in subfemtomole amounts by gas chromatography/negative ion/chemical ionization mass spectrometry. Application to long-chain acyl-coenzyme A measurement. Chromatography 1990; 509: 325:332. PMID: 2211898
  48. Hughes JH, Watson MA, Easom RA, Turk J, & McDaniel ML: Interleukin-1 induces rapid and transient expression of the c-fos proto-oncogene in isolated pancreatic islets and in purified beta cells. FEBS Lett. 1990; 266: 33-36. PMID: 2203826
  49. Hughes JH, Colca JR, Easom RA, Turk J, & McDaniel ML: Interleukin-1 inhibits insulin secretion from isolated rat pancreatic islets by a process that requires gene transcription and mRNA translation. Clin. Invest. 1990; 86: 856-863. PMID: 2203826
  50. Easom R, Landt M, Colca J, Hughes J, Turk J, & McDaniel ML: Effects of insulin secretagogues on protein kinase C-catalyzed phosphorylation of an endogenous substrate in isolated pancreatic islets. Biol. Chem. 1990; 265: 14938-14946. PMID: 2203765
  51. Turk J, Stump WT, Conrad-Kessel W, Seabold R, & Wolf B: Quantitation of epoxy- and dihydroxy-eicosatrienoic acids by stable isotope dilution mass spectrometry. Enzymol. 1990; 187: 175-186. PMID: 2233344
  52. Bodor G, Roggeman R, & Turk J: Variations in abundance of the molecular ion of the derivatized cocaine metabolite benzoylecgonine. Chem. 1990; 36: 742-747. PMID: 2337982
  53. Wolf BA, Williamson JR, Easom R, Chang K, Sherman WR, & Turk J: Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels. Clin. Invest. 1991; 87: 31-36. PMID: 1985103
  54. Holtzman MJ, Ferdman B, Bohrer A, & Turk J. Synthesis of the 1-0-hexadecyl molecular species of platelet activating factor by airway epithelial and vascular endothelial cells. Biophys. Res. Commun. 1991; 177: 357-364. PMID: 2043121
  55. Wolf BA, Pasquale SM, & Turk J: Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion. Biochemistry 1991; 30: 6372-6379. PMID: 1905151
  56. Mangino M, Murphy M, Anderson CB, & Turk J: Renal allograft platelet activating factor synthesis during acute cellular rejection in canines. J. Lipid Mediators 1991; 4: 69-82. PMID: 1893087
  57. Landt M, Easom RA, Colca JR, Wolf BA, Turk J, Mills LA, & McDaniel ML. Parallel effects of arachidonic acid on insulin secretion, calmodulin-dependent protein kinase activity and protein kinase C activity in pancreatic islets. Cell Calcium 1992; 13: 163-172. PMID: 1315620
  58. Riehl TE, Turk J, & Stenson WF: Metabolism of oxygenated derivatives of arachidonic acid by Caco-2 cells. J. Lipid Res. 1992; 33: 323-331. PMID: 1314878
  59. Ramanadham S, Gross RW, & Turk J: Arachidonic acid induces an increase in cytosolic calcium concentration in single pancreatic islet beta cells. Biochem. Biophys. Res. Commun. 1992; 184: 647-653. PMID: 1575739
  60. Turk J, Bohrer A, Stump WT, Ramanadham S, & Mangino MJ: Quantification of distinct molecular species of the 2-lyso metabolite of platelet activating factor by gas chromatography-negative ion chemical ionization-mass spectrometry. J. Chromatography 1992; 575: 183-196. PMID: 1629294
  61. Turk J, Mueller M, Bohrer A, & Ramanadham S: Arachidonic acid metabolism in isolated pancreatic islets VI. Carbohydrate insulin secretagogues must be metabolized to induce eicosanoid release. Biochim. Biophys. Acta 1992; 1125: 280-291. PMID: 1596516
  62. Holtzman MJ, Turk J, & Skornick LP: Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells. J. Biol. Chem. 1992; 267: 21438-21445. PMID: 1400457
  63. Shannon VR, Ramanadham S, Turk J, & Holtzman MJ: Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet beta cells. Am. J. Physiol. 1992; 263: E908-E912. PMID: 1443114
  64. Koranyi L, Bourey R, Turk J, Mueckler M, & Permutt MA: Differential expression of islet beta cell glucose transporter (GLUT-2) and amylin genes in rats after prolonged fasting, insulin-induced hypoglycemia, and dexamethasone treatment. Diabetologia 1992; 35: 1125-1132. PMID: 1282477
  65. Gross R, Ramanadham S, Kruszka K, Han X, & Turk J. Rat and human pancreatic islet cells contain a calcium-independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by ATP and specifically localized to islet beta cells. Biochemistry 1993; 32: 327-336. PMID: 8418853
  66. Ramanadham S, Gross RW, Han X, & Turk J: Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta cell cytosolic calcium concentration. Biochemistry 1993; 32: 337-346. PMID: 8418854
  67. Ramanadham S, Bohrer A, Mueller M, Jett P, Gross R, & Turk J: Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: Prominence of plasmenylethanolamine molecular species. Biochemistry 1993; 32: 5339-5351. PMID: 8499439
  68. Ramanadham S, Bohrer A, Gross RW, & Turk J: Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta cells and subcellular membranes. Biochemistry 1993; 32: 13499-13509. PMID: 8257685
  69. Lehman J, Brown KA, Ramanadham S, Turk J, & Gross RW: The majority of arachidonic acid release induced by vasopressin stimulation of rat aortic smooth muscle cells is mediated by calcium-independent phospholipase A2. J. Biol. Chem. 1993; 268: 20713-20716. PMID: 8407892
  70. Corbett JA, Kwon G, Turk J, & McDaniel ML: IL-1b induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: Activation of cyclooxygenase by nitric oxide. Biochemistry 1993; 32: 13767-13770. PMID: 7505613
  71. Turk J, Corbett JA, Bohrer A, Ramanadham S, & McDaniel ML: Biochemical evidence for nitric oxide production from streptozotocin in isolated pancreatic islets. Biochem. Biophys. Res. Commun. 1993; 197: 1458-1464. PMID: 7904159
  72. Stenson WF, Easom R, & Turk J: Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C. Am. J. Physiol. 1993; 265: G955-G962. PMID: 8238525
  73. Turk J, Gross R, & Ramanadham S: Amplification of insulin secretion by lipid messengers. Diabetes 1993; 42: 367-374. PMID: 8432406
  74. Turk J, Aks S, Ampuerro F, & Hryhorczuk DO: Successful therapy of iron intoxication in pregnancy with intravenous deferoxamine and whole bowel irrigation. V.H. Toxicology, 1993; 35: 441-444. PMID: 8249269
  75. Turk J, Aks S, & Hryhorczuk DO: Constraints on the enhancement of elimination of drugs with activated charcoal. V.H. Toxicology, 1993; 35: 489-494. PMID: 8303814
  76. Ramanadham S & Turk J: w-Conotoxin inhibits glucose- and arachidonic acid-induced rises in intracellular [Ca2+] in rat pancreatic islet beta cells. Cell Calcium 1994; 15: 259-264. PMID: 8194105
  77. Ramanadham S, Wolf M, Jett PA, Gross RW, & Turk J: Characterization of an ATP-stimulatable, Ca2+-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: A possible molecular component of the beta cell fuel sensor. Biochemistry 1994; 33: 7442-7452. PMID: 8003509
  78. Heinecke J, Li W, Bohrer A, & Turk J: Cholesterol chlorohydrin synthesis by the myeloperoxidase-hydrogen peroxide-halide system: Potential markers for lipids oxidatively damaged by activated phagocytes. Biochemistry 1994; 33: 10127-10136. PMID: 8060981
  79. Mangino MJ, Murphy M, Bohrer A, & Turk J. Platelet activating factor synthesis and metabolism in intestinal ischemia-reperfusion injury. Med. Inflamm. 1994; 33: 393-395. PMID: 18475586
  80. Wong EC, Koenig J, & Turk J: Potential interference of cyclobenzaprine and norcyclobenzaprine with HPLC measurement of amitriptyline and nortriptyline. Resolution by GC-MS analysis. J. Anal. Tox. 1995; 19: 218-224. PMID: 8531466
  81. Dietzen DJ, Koenig J, & Turk J. Facilitation of the thin layer chromatographic identification of opiates by derivatization with acetic anhydride or methoxyamine. J. Anal. Tox. 1995; 19: 299-304. PMID: 7500616
  82. Ma Z, Ramanadham S, Corbett J, Bohrer A, Gross RW, McDaniel ML, & Turk J. Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism. J. Biol. Chem. 1996; 271: 1029-1042. PMID: 8557627
  83. Thyssen E, Turk J, Bohrer A, & Stenson WF. Quantification of distinct molecular species of platelet activating factor in ulcerative colitis. Lipids 1996; 31: S255-S259. PMID: 8729129
  84. Kwon G, Bohrer A, Han X, Ma Z, Corbett J, Gross R, McDaniel M, & Turk J. Characterization of the sphingomyelin content of pancreatic islets. Evaluation of the role of sphingomyelin hydrolysis in the action of interleukin-1 to induce islet overproduction of nitric oxide. Biochim. Biophys. Acta 1996; 1300: 63-72. PMID: 8608164
  85. Hsu FF, Lakshmi V, Rothman N, Bhatnager VK, Hayes RB, Kashyap R, Parikh DJ, Kashyap SK, Turk J, Zenser T, & Davis B. Determination of benzidine, N-acetylbenzidine, and N,N’-diacetylbenzidine in human urine by capillary gas chromatography/negative ion chemical ionization mass spectrometry. Anal. Biochem. 1996; 234: 183-189. PMID: 8714596
  86. Ramanadham S, Wolf M, Ma Z, Li B, Wang J, Gross RW, & Turk J. Evidence for association of an ATP-stimulatable Ca2+-independent phospholipase A2 from pancreatic islets and HIT insulinoma cells with a phosphofructokinase-like protein. Biochemistry, 1996; 35, 5464-5471. PMID: 8611537
  87. Corbett JA, Kwon G, Marino MH, Rodi CP, Sullivan PM, Turk J, & McDaniel ML. Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets of Langerhans. Am. J. Physiol. 1996; 270: C1581-C1587. PMID: 8764139
  88. Stickle D, Bohrer A, Berger R, Morrisey J, Klahr S, & Turk J. Quantitation of the putative neurotransmitter agmatine as the hexafluoroacetylacetonate derivative by stable isotope dilution gas chromatography and negative ion chemical ionization mass spectrometry. Anal. Biochem. 1996; 238: 129-136. PMID: 8660601
  89. Kempe K, Hsu FF, Bohrer A, & Turk J. Isotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post-mortem but is contained at low levels in or is absent from fresh tissue. J. Biol. Chem. 1996; 271: 17287-17295. PMID: 8663381
  90. Ma Z, Ramanadham S, Kempe K, Hu Z, Ladenson JH, & Turk J. Characterization of expression of isoforms of phosphofructokinase in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform. Biochim. Biophys. Acta 1996; 1308: 151-163. PMID: 8764833
  91. Wolf MJ, Wang J, Turk J, & Gross RW. Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid release. J. Biol. Chem. 1997; 272: 1522-1526. PMID: 8999823
  92. Ramanadham S, Wolf M, Li B, Bohrer A, & Turk J. Glucose-responsivity and expression of an ATP-stimulatable, Ca2+-independent phospholipase A2 enzyme in clonal insulinoma cell lines. Biochim. Biophys. Acta, 1997; L1344: 153-164. PMID: 9030192
  93. Ma Z, Ramanadham S, Kempe K, Chi XS, Ladenson J, & Turk J. Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin. J. Biol. Chem. 1997; 272: 11118-11127. PMID: 9111008
  94. Ma Z, Landt M, Bohrer A, Ramanadham S, Kipnis DM, & Turk J. Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism. J. Biol. Chem. 1997; 272: 17827-17835. PMID: 9211938
  95. Stickle D, Ramanadham S, & Turk J. Effects of arachidonyltrifluoromethyl ketone on cytosolic [Ca2+] in HIT insulinoma cells. J. Lipid Mediators Cell. Signal 1997; 17: 65-70. PMID: 9302655
  96. Stickle D & Turk J. A kinetic mass balance model of 1,5-anhydroglucitol. Applications to monitoring of glycemic control. Am. J. Physiol. 1997; 273: E821-E830. PMID: 9357814
  97. Ramanadham S, Ma Z, Arita H, Zhang S, & Turk J. Type IB secretory phospholipase A2 is contained in the insulin secretory granules of pancreatic islet beta cells and is co-secreted with insulin upon stimulation of islets with glucose. Biochim. Biophys. Acta 1998; 1390: 301-312. PMID: 9487151
  98. Ramanadham S, Hsu FF, Bohrer A, Nowatzke W, Ma Z, & Turk J. Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes. Comparison to other tissues and implications for membrane fusion in insulin exocytosis. Biochemistry 1998; 37: 4533-4567. PMID: 9521776
  99. Hsu FF, Bohrer A, & Turk J. Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry. J. Am. Soc. Mass Spectrom. 1998; 9: 516-526. PMID: 9879366
  100. Ma Z, Ramanadham S, & Turk J. Cloning and expression of a type IV cytosolic phospholipase A2 enzyme from a pancreatic islet cDNA library. Comparison of the expressed activity with that of the islet type VI cytosolic phospholipase A2. Biochim. Biophys. Acta 1998; 1391: 384-400. PMID: 9555100
  101. Kwon G, Corbett JA, Hill JR, Turk J, & McDaniel ML. Evidence for involvement of the proteasome complex (26S) and NFkB in IL-1-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes 1998; 47: 583-591. PMID: 9568691
  102. Crowley J, Leeuwenburgh C, Yarasheski K, Turk J, & Heinecke J. Isotope dilution mass spectrometric measurement of 3-nitro-tyrosine is facilitated by reduction to 3-amino-tyrosine. Biochem., 1998; 259: 127-135. PMID: 9606153
  103. Way BA, Stickle D, Bohrer A, Koenig JW, & Turk J. Isotope dilution gas chromatographic mass spectrometric measurement of tricyclic antidepressant drugs. Utility of the 4-carboethoxyhexafluorobutyryl derivatives of secondary amines. Anal. Tox. 1998; 22: 374-382. PMID: 9737332
  104. Hsu FF, Bohrer A, & Turk J. Electrospray ionization tandem mass spectrometric analysis of sulfatide. Determination of fragmentation patterns and characterization of sulfatide molecular species expressed in brain and pancreatic islets. Biophys. Acta 1998; 1392: 202-216. PMID: 9630631
  105. Nowatzke W, Ramanadham S, Hsu FF, Ma Z, Bohrer A, & Turk J. Mass spectrometric evidence that agents which cause loss of Ca2+ from intracellular compartments induce hydrolysis of arachidonic acid from pancreatic islet membrane phospholipids by a mechanism that does not require a rise in cytosolic Ca2+ Endocrinology 1998; 139: 4073-4085. PMID: 9751485
  106. Han X, Ramanadham S, Turk J, & Gross RW. Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes. Catalysis by a protein constituent recognized by a monoclonal antibody directed against glyceraldehyde-3-phosphate dehydrogenase. Biophys. Acta 1998; 1414: 95-107. PMID: 9804907
  107. Powell T, Turk J, Hsu FF, & Hruska K. Ephedrine nephrolithiasis. A first case report. J. Kidney Dis.1998; 32: 153-159. PMID: 9669437
  108. Hsu FF, Giblin D, Hazen SL, Turk J, Heinecke J, & Gross ML. Mass spectrometric analysis of pentafluorobenzyl oxime derivatives of biological aldehydes. J. Mass Spectrometry 1999; 185/186/187: 795-812.
  109. Nowatzke W, Zeng J, Saunders A, Bohrer A, Koenig J, & Turk J. Distinction among eight opiate drugs in urine by gas chromatography-mass spectrometry. Pharm. Biomed. Anal. 1999; 20: 815-28. PMID: 10701990
  110. Ma Z, Wang X, Nowatzke W, Ramanadham S, & Turk J. Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1. Biol. Chem. 1999; 274: 9607-9616. PMID: 10092647
  111. Ramanadham S, Hsu FF, Bohrer A, Ma Z, & Turk Studies of the role of group VI phospholipase A2 (iPLA2) in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells. J. Biol. Chem. 1999; 274: 13915-13927. PMID: 10318801
  112. Hsu FF & Turk J. Structural characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low energy collisionally activated dissociation on a triple stage quadrupole instrument. Am. Soc. Mass Spectrom. 1999; 10: 587-600. PMID: 10384723
  113. Hsu FF & Turk J. Distinction among isomeric unsaturated fatty acids as lithiated adducts by electrospray ionization mass spectrometry using low energy collisionally activated dissociation on a triple stage quadrupole instrument. Am. Soc. Mass Spectrom. 1999; 10: 600-613. PMID: 10384724
  114. Yarasheski K, Tebas P, Sigmund C, Dagogo-Jack S, Bohrer A, Turk J, Halban P, Cryer P, & Powderly W. Insulin resistance in HIV-protease inhibitor-associated diabetes. Acquired Immune Deficiency Syndromes 1999: 21: 209-216. PMID: 10421244
  115. Heinecke JW, Hsu, FF, Crowley JR, Hazen SL, Leeuwenburgh C, & Turk J. Detecting oxidative modification of biomolecules in vivo with isotope dilution mass spectrometry. Sensitive and quantitative assays for oxidized amino acids in proteins and tissues. Enzymol. 1999; 300: 124-144. PMID: 9919517
  116. Hsu FF & Turk J. Structural determination of sphingomyelin by tandem mass spectrometry with electrospray ionization. J. Am. Soc. Mass Spectrom. 2000; 11: 437-449. PMID: 10790848
  117. Hsu FF & Turk J. Characterization of phosphatidylethanolamine molecular species as lithiated adducts by triple quadrupole tandem mass spectrometry with electrospray ionization. J. Mass Spec. 2000; 35: 596-606. PMID: 10800048
  118. Ramanadham S, Hsu FF, Zhang S, Bohrer A, Ma Z, & Turk J. Electrospray ionization mass spectrometric analysis of INS-1 insulinoma cell phospholipids. Comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion. Biochim. Biophys. Acta 2000; 1484: 251-266. PMID: 10760474
  119. Hsu FF, Ma Z, Wohltmann M, Bohrer A, Ramanadham S, & Turk J. Electrospray ionization mass spectrometric analysis of human promonocytic U937 cell glycerolipids and evidence that differentiation is associated with membrane lipid composition changes that facilitate phospholipase A2 activation. J. Biol. Chem. 2000; 275: 16579-16589. PMID: 10748096
  120. Hsu FF & Turk J. Charge-driven fragmentation processes in diacyl glycerophosphatidic acids upon low-energy collisional activation. A mechanistic proposal. Mass Spec. 2000; 11: 797-803. PMID: 10976887
  121. Hsu FF, Bohrer A, Wohltmann M, Ramanadham S, Ma Z, Yarasheski K, & Turk J. Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty fats. Lipids 2000; 35: 839-854. PMID: 10984107
  122. Hsu FF & Turk J. Charge-remote and charge-driven fragmentation processes in diacyl glycerophosphoethanolamine upon low-energy collisional activation: A mechanistic proposal. Am. Soc. Mass Spectrom. 2000: 11: 892-899. PMID: 11014451
  123. Hsu FF & Turk J. Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry. A mechanistic study. Am. Soc. Mass Spectrom. 2000; 11: 986-999. PMID: 11073262
  124. Hsu FF & Turk J. Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low energy collisionally activated dissociation on a triple stage quadrupole instrument. J. Am. Soc. Mass Spectrom. 2001; 12: 61-79. PMID: 11142362
  125. Ma Z, Ramanadham S, Wohltmann M, Bohrer A, Hsu FF, & Turk J. Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress Group VIA Phospholipase A2 (iPLA2b) indicate a signaling rather than a housekeeping role for iPLA2b. Biol. Chem. 2001; 276: 13198-13208. PMID: 11278673
  126. Ma Z, Bohrer A, Wohltmann M, Ramanadham S, Hsu FF, & Turk J. Studies of phospholipid metabolism, proliferation, and secretion of stably transfected insulinoma cells that overexpress Group VIA Phospholipase A2. Lipids 2001; 36: 689-700. 11521967
  127. Hsu FF & Turk J. Studies on phosphatidylglycerol with triple quadrupole mass spectrometry with electrospray ionization. Fragmentation processes and structural characterization. Am. Soc. Mass Spectrom. 2001; 12: 1036-1043. PMID: 11142362
  128. Ghomashchi F, Hefner Y, Ramanadham S, Turk J, Leslie CC, & Gelb MH. A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2a blocks arachidonic acid release in a variety of mammalian cells. Biophys. Acta 2001; 1513: 160-166. PMID: 11470087
  129. Ramanadham S, Zhang S, Ma Z, Bohrer A, Hsu FF, & Turk J. Fatty acyl-CoA desaturase enzymes are expressed in insulin-secreting beta cells, and expression levels are altered by extracellular concentrations of polyunsaturated fatty acids. Biophys. Acta 2002: 1580: 50-56. PMID: 11923099
  130. Markaverich BM, Alejandro MA, Markaverich D, Zitow L, Casajuna N, Camarao N, Hill J, Bhirdo K, Faith R, Turk J, & Crowley J. Identification of a novel endocrine-disrupting agent in corn products that stimulates breast cancer cell proliferation. Biophys. Res. Commun. 2002; 291: 692-700. PMID: 11855846
  131. Ma Z, Zhang S, Turk J, & Ramanadham S. Stimulation of insulin secretion and associated nuclear accumulation of iPLA2b in INS-1 insulinoma cells. J. Physiol. 2002; 282: E820-833. PMID: 11882502
  132. Hsu FF & Turk J. Characterization of ceramides by low energy collisionally activated dissociation negative ion tandem mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2002; 13: 558-571. PMID: 12019979
  133. Clement L, Kim-Sohn KA, Magnan C, Kassis N, Adnot P, Kergoat M, Assimacopoulos-Jeannet F, Penicaud L, Hsu FF, Turk J, & Ktorza A. Pancreatic beta cell alpha 2A adrenoreceptors and phospholipid changes in hyperlipidemic rats. Lipids 2002: 37: 501-506. PMID: 12056593
  134. Hsu FF, Turk J, Stewart ME, & Downing DT. Structural studies of ceramides as lithiated adducts by low energy collisionally activated dissociation tandem mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2002; 13: 680-695. PMID: 12056568
  135. Hsu FF & Turk J. Electrospray ionization/tandem quadrupole mass spectrometric studies on phosphatidylcholines: The fragmentation processes. J Am. Soc. Mass Spectrom. 2003: 14: 352-363. PMID: 12686482
  136. Hsu FF, Turk J, & Gross ML. Structural distinction among inositol phosphate isomers using high-energy and low-energy CAD tandem mass spectrometry with electrospray ionization. Mass Spectrom. 2003: 38: 447-457. PMID: 12717757
  137. Rhoades E, Hsu FF, Turk J, & Russell D. Identification and macrophage-activating activity of glycolipids released from intracellular mycobacterial species. Molecular Microbiology 2003; 48: 875-888. PMID: 12753183
  138. Zhang K, Showalter M, Revello J, Hsu FF, Turk J, & Beverley SM. Sphingolipids are essential for differentiation but not growth in Leishmania. EMBO J. 2003; 22: 6016-6026. PMID: 14609948
  139. Hsu FF, Turk J, Thukkani AK, Messner MC, Wildsmith KR, & Ford DA. Characterization of alkylacyl-, alk-1-enylacyl, and lyso subclasses of glycerophosphocholine lipids by tandem quadrupole mass spectrometry with electrospray ionization. Mass Spectrom. 2003; 38: 752-763. PMID: 12898655
  140. Ramanadham S, Song H, Hsu FF, Zhang S, Crankshaw M, Grant G, Newgard C, & Turk J. Pancreatic islets and insulinoma cells express a novel isoform of Group VIA phospholipase A2 (iPLA2β) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2β transcript. Biochemistry 2003; 42: 13929-13940. PMID: 14636061
  141. Hsu FF, Turk J, Shi Y, & Groisman EA. Characterization of acylphosphatidylglycerols from Salmonella typhimurium by tandem mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2004; 15: 1-11. PMID: 14698549
  142. Ramanadham S, Song H, Bao S, Hsu FF, Zhang S, Ma Z, Jin C, & Turk J. Islet complex lipid involvement in the actions of Group VIA calcium-independent phospholipase A2 in beta cells. Diabetes 2004; 53: S175-S185. PMID: 14749285
  143. Bao S, Jin C, Zhang S, Turk J, Ma Z, & Ramanadham S. The beta cell calcium-independent Group VIA phospholipase A2 (iPLA2b). Tracking iPLA2b movements in response to stimulation with insulin secretagogues in INS-1 cells. Diabetes 2004; 53: S186-S189. PMID: 14749286
  144. Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Ma Z, & Turk J. Involvement of the Group VIA Phospholipase A2 (iPLA2b) in endoplasmic reticulum stress-induced apoptosis in insulinoma cells. Biochemistry 2004: 43: 918-930. PMID: 14744135
  145. Hsu FF & Turk J. Studies on sulfatides by quadrupole ion-trap mass spectrometry with electrospray ionization. Structural characterization and the fragmentation processes that include an unusual internal galactose residue loss and the classical charge-remote fragmentations. Am. Soc. Mass Spectrom. 2004; 15: 536-546. PMID: 15047058
  146. Luzzi VI, Saunders AN, Koenig JW, Turk J, Lo SF, Garg UC, & Dietzen DJ. Analytic performance of immunoassays for drugs of abuse below established cutoff values. Clin. Chem. 2004; 50: 717-723. PMID: 14764642
  147. Lee H, Hsu FF, Turk J, & Groisman EA. The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of the lipid A and polymyxin resistance in Salmonella enterica. Bacteriol. 2004; 186: 4124-33. PMID: 15205413
  148. Shi Y, Cromie MJ, Hsu FF, Turk J, & Groisman EA. PhoP regulated Salmonella resistance to the antimicrobial peptides maganin 2 and polymyxin B. Microbiol. 2004; 53: 229-241. PMID: 15225317
  149. Bao S, Miller DJ, Ma Z, Wohltmann M, Eng G, Ramanadham S, Moley K, & Turk J. Male mice that do not express Group VIA Phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility. Biol. Chem. 2004; 279: 38194-38200. PMID: 15252026
  150. Song H, Hecimovic S, Goate A, Hsu FF, Bao S, Vidavsky I, Ramanadham S, & Turk J. Characterization of N-terminal processing of Group VIA Phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests. Am. Soc. Mass Spectrom. 2004; 15: 1780-1793. PMID: 15589755
  151. Wang Z. Ramanadham S, Ma Z, Bao S, Mancuso DJ, Gross RW, & Turk J. Group VIA Phospholipase A2 (iPLA2β) forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIβ expressed in pancreatic islet β-cells. Biol. Chem. 2005; 280: 6840-6849. PMID: 15576376
  152. Zhang K, Hsu FF, Scot DA, Docampo R, Turk J, & Beverley SM. Salvage and remodeling of host sphingolipids in Leishmania amastigote survival and acidocalcisome biogenesis. Molec. Microbiol. 2005; 55: 1566-1578. PMID: 15720561
  153. Hsu FF, Turk J, Rhoades ER, Russell DG, Shi Y, & Groisman EA. Structural characterization of cardiolipin by tandem quadrupole and multiple stage quadrupole ion-trap mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2005; 16: 491-504. PMID: 15792718
  154. Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider J, Coleman T, Turk J, & Semenkovich CF. New hepatic fat activates PPARa to maintain glucose, lipid, and cholesterol homeostasis. Cell Metabolism 2005; 1: 309-322. PMID: 16054078
  155. Hsu FF & Turk J. Structural studies on phosphatidylserine by tandem quadrupole and multiple stage quadrupole ion-trap mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom., 2005; 16: 1510-1522. PMID: 16023863
  156. Moran JM, Buller RML, McHowat J, Turk J, Wohltmann M, Gross RW, & Corbett JA. Genetic and pharmacologic evidence that iPLA2β regulates virus-induced iNOS expression by macrophages. Biol. Chem. 2005; 280: 28162-28168. PMID: 15946940
  157. Shoulars K, Rodrigues MA, Crowley J, Turk J, Thompson T, & Markaverich BM. Nuclear type II [3H]estradiol binding sites: A histone H3-H4 complex. Steroid Biochem. Molec. Biol. 2005; 96: 19-30. PMID: 15878266
  158. Bao S, Bohrer A, Ramanadham S, Jin W, Zhang S, Turk J. Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells. Biol. Chem. 2006; 281: 187-198. PMID: 16286468
  159. Song H, Ramanadham S, Bao S, Hsu FF, & Turk J. A bromoenol lactone suicide substrate inactivates Group VIA Phospholipase A2 by generating a diffusible bromomethyl ketoacid that alkylates cysteine thiols. Biochemistry 2006; 45: 1061-73. PMID: 16411783
  160. Hsu FF & Turk J. Characterization of cardiolipin from Escherichia coli by electrospray ionization with multiple stage quadrupole ion-trap mass spectrometric analysis of [M-2H+Na]- J. Am. Soc. Mass Spectrom. 2006; 17: 420-429. PMID: 16442306
  161. Woodworth A, Saunders AN, Koenig JW, Moyer TP, Turk J, & Dietzen DJ. Rapid discrimination between urine samples containing amphetamine/methamphetamine and those containing other cross-immunoreactive sympathomimetic amines by serial dilution testing. Chem. 2006; 52: 743-746. PMID: 16455869
  162. Shoulars K, Rodriguez MA, Crowley J, Turk J, Thompson T, & Markaverich BM. Reconstitution of the type II [3H]estradiol binding site with recombinant histone H4. J Steroid Biochem. Mol. Biol. 2006; 99:1-8. PMID: 16621524
  163. Song H, Bao S, Ramanadham S, & Turk J. Effects of biological oxidants on the catalytic activity and structure of Group VIA Phospholipase A2. Biochemistry 2006; 45: 6392-6404. PMID: 16700550
  164. Bao S, Song H, Wohltmann M, Bohrer A, & Turk J. Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA Phospholipase A2 and effects of metabolic stress on glucose homeostasis. Biol. Chem. 2006; 281: 20958-20973. PMID: 16732058
  165. Hsu FF & Turk J. Characterization of cardiolipins as sodiated adducts by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometry.
    Am. Soc. Mass Spectrom 2006; 17: 1146-57. PMID: 16750386
  166. Nishino K, Hsu FF, Turk J, Cromie MJ, Wösten M, & Groisman EA. Identification of the lipopolysaccharide modifications controlled by the Salmonella PmrA/PmrB system mediating resistance to Fe(III) and Al(III). Molecular Microbiology 2006; 61: 645-654. PMID: 16803591
  167. Yan P, Hu X, Song H, Yin K, Bateman RJ, Cirrito JR, Xiao Q, Hsu FF, Turk J, Xu J, Chung Y, Hsu CY, Holtzman DM, & Lee JM. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. Biol. Chem. 2006; 281: 24566-24574. PMID: 16787929
  168. Yin KY, Cirrito JR, Yan P, Hu X, Xiao Q, Pan X, Bateman R, Song H, Hsu FF, Turk J, Xu J, Hsu CY, Mills JC, Holtzman DM, & Lee JM. Matrix metalloproteinases expressed by astrocytes mediate extracellular Ab J. Neuroscience 2006;26:10939-48. PMID: 17065436
  169. Dietzen DJ, Page KL, Tetzloff TA, Bohrer A, & Turk J. Inhibition of HMGCoA reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. Thromb. Vasc. Biol. 2007; 27: 690-696. PMID: 17185615
  170. Zhang K, Pompey JM, Hsu FF, Turk J, & Beverley SM. Remodeling of sphingolipid metabolism towards de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007; 26: 1094-1104. PMID: 17290222
  171. Jacobson DA, Webber C, Bao S, Turk J, & Philipson LH. Modulation of the pancreatic islet beta cell delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. Biol. Chem. 2007; 282: 7442-7449. PMID: 17197450
  172. Hsu FF, Turk J, Owens RM, Rhoades ER, Russell DG. Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. I. PIMs and Lyso-PIMs. Am. Soc. Mass Spectrom. 2007; 18: 466-478. PMID: 17141526
  173. Hsu FF, Turk J, Owens RM, Rhoades ER, Russell DG. Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. II. PIMs and Lyso-PIMs. Am. Soc. Mass Spectrom. 2007;18: 479-492. PMID: 17141525
  174. Hsu FF, Turk J, Williams TD, & Welti R. Characterization of phosphatidylglycerol in plant chloroplasts by multiple stage quadrupole ion-trap and tandem quadrupole mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2007;18:783-790. PMID: 17303435
  175. Markaverich BM, Alejandro M, Thompson T, Mani S, Reyna A, Portillo W, Sharp J, Turk J, & Crowley J. Tetrahydrofurandiols, leukotoxindiols, and endocrine disruption in rats. Health Perspect. 2007; 115:702-8. PMID: 17520056
  176. Hsu FF, Turk J, Zhang K, & Beverley SM. Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2007; 18: 1591-1604. PMID: 17627842
  177. Xie Z, Gong MC, Su W, Turk J, & Guo Z. Group VIA phospholipase A2 (iPLA2b) participates in angiotensin II-induced transcriptional upregulation of RGS2 in vascular smooth muscle cells. Biol. Chem. 2007; 282: 25278-89. PMID: 17613534
  178. Bao S, Li Y, Lei X, Wohltmann M, Bohrer A, Jin W, Ramanadham S, Tabas I, & Turk J. Attenuated free cholesterol loading-induced apoptosis and preserved phospholipid composition of peritoneal macrophages from mice that do not express Group VIA Phospholipase A2. Biol. Chem. 2007; 282: 27100 –27114. PMID: 17627946
  179. Song H, Hsu FF, Ladenson J, & Turk J. Algorithm for processing raw electronic mass spectrometric data to identify and quantitate complex lipid molecular species. Am. Soc. Mass Spectrom. 2007; 18: 1848-58. PMID: 17720531
  180. Nikolic DM, Gong MC, Turk J, & Post SR. SR-A-mediated macrophage adhesion requires coupling of iPLA2 and 12/15-lipoxygenase to RAC activation. Biol. Chem. 2007; 282: 2065-2073. PMID: 17873277
  181. Hsu FF & Turk J. Differentiation of 1-O-alk-1′-enyl-2-acyl and 1-O-alkyl-2-acyl glycerophospholipids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2007; 18: 2065-73. PMID: 17913512
  182. Malik I, Turk J, Mancuso DJ, Montier L, Wohltmann M, Wozniak D, Schmidt RE, Gross RW, & Kotzbauer PT. Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model for human infantile neuroaxonal dystrophy caused by PLA2G6 mutations. J. Pathol. 2008; 172: 406-416. PMID: 18202189
  183. Bao S, Jacobson D, Wohltmann M, Bohrer A, Jin W, Philipson LH, & Turk J. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2b-null mice. J. Physiol. Endocrinol. Metab. 2008; 294: E217-29. PMID: 17895289. PMCID: PMC2268609
  184. Ramanadham S, Yarasheski KE, Silva MJ, Wohltmann M, Veis-Novack D, Lei XY, & Turk J. Age-related changes in bone morphology are accelerated in group VIA calcium-independent phospholipase A2β (iPLA2β)-null mice. J. Pathol. 2008; 172: 868–881. PMID: 18349124. PMCID: PMC2276416.
  185. Shoulars K, Mary Rodriguez A, Thompson T, Turk J, Crowley J, & Markaverich BM. Regulation of the nitric oxide pathway genes by tetrahydrofurandiols: Microarray analysis of MCF-7 human breast cancer cells. Cancer Lett. 2008; 264: 265-73. PMID: 18346845
  186. Nodari F, Hsu FF, Fu X, Holekamp TF, Kao LF, Turk J, & Holy TE. Sulfated steroids as natural ligands of mouse pheromone-sensing neurons. Neurosci. 2008; 28: 6407-6418. PMID: 18562612
  187. Sutterwala SS, Hsu FF, Schwartz KJ, Sevova E, Key P, Turk J, Beverley S, & Bangs JD. Developmentally regulated sphingolipid synthesis in African trypanosomes. Molecular Microbiology 2008; 70: 281-96. PMID: 18699867
  188. Song H, Kong W, Weatherspoon N, Qin G, Tyler W, Turk J, Curtiss R, & Shi Y. Modulation of the regulatory activity of bacterial two-component systems to SLYA. Biol. Chem. 2008; 283: 28158-28168. PMID: 18678876
  189. Hsu FF & Turk J. Elucidation of the double bond position of long-chain unsaturated fatty acids by multiple-stage linear ion-trap mass spectrometry with electrospray Ionization. Am. Soc. Mass Spectrom. 2008; 19:1673-80. PMID: 18692406. PMCID: PMC2595141.
  190. Hsu FF & Turk J. Structural characterization of unsaturated glycerophospholipids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2008; 19:1681-91. PMID: 18771936. PMCID: PMC2639777.
  191. Carper MJ, Zhang S, Song H, Turk J, & Ramanadham S. Skeletal muscle Group VIA Phospholipase A2 (iPLA2β): Expression and role in fatty acid oxidation. Biochemistry 2008; 47: 12241-9. PMID: 18937505
  192. Moon SH, Christopher M. Jenkins CM, Mancuso DJ, Turk J, & Gross RW. Arachidonic acid release induced by thapsigargin or ionophore is ablated in aortic smooth muscle cells from mice null for Ca2+-independent PLA2β. Attenuation of smooth muscle cell migration and proliferation in iPLA2β-/- J. Biol. Chem. 2008; 283: 33975-87. PMID: 18927078
  193. Hsu FF, Nodari F, Kao LF, Fu X, Holekamp TF, Turk J, & Holy TE. Structural characterization of sulfated steroids that activate mouse pheromone-sensing neurons. Biochemistry 2008; 47: 14009-19. PMID: 19053227.
  194. Liu C, Shen CR, Hsu FF, Chen JK, Wu PT, G SH, Lee WC, Yu FW, Mackey ZB, Turk J, & Gross ML. Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii. Prog. 2009; 25: 124-131. PMID: 19197977.
  195. Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RRV, Xu HE, Turk J, & Semenkovich CF. Identification of a physiologically relevant endogenous ligand for PPARα in liver. Cell 2009; 138: 476-88. PMID: 19646743.
  196. Zhang O, Wilson MC, Hsu FF, Turk J, Kuhlmann F, Beverley SM, & Zhang K. Degradation of host-derived sphingolipids is essential for acute virulence in Leishmania PLoS Pathogens 2009; 5(12): e1000692. PMID: 20011126. PMCID: PMC2784226.
  197. Franchi L, Chen G, Marina-Garcia N, Abe A, Qu Y, Bao S, Shayman JA, Turk J, Dubyak GR, Nunez G. Calcium-Independent Phospholipase A2 is dispensable in inflammasome activation and its inhibition by bromoenol lactone. Innate Immun. 2009; 1: 607–617. PMID: 20160900.
  198. Xie Z, Su W, Xie D, Turk J & Guo Z. Role of calcium-independent phospholipase A2β in high glucose-induced activation of RhoA, Rho-kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals. Biol. Chem. 2010; 285: 8628-8638. PMID: 20086008
  199. Song H, Bao S, Lei X, Jin C, Zhang C, Turk J, & Ramanadham S. Evidence for proteolytic processing and organelle-specific localization of iPLA2b. Biophys. Acta 2010; 180: 547-558. PMID 20132906
  200. Hsu FF & Turk J. Electrospray ionization multiple-stage linear ion-trap mass spectrometry for structural elucidation of triacylglycerols: Assignment of fatty acyl groups on the glycerol backbone and location of double bonds. Am. Soc. Mass Spectrom. 2010; 21: 657-69. PMID: 20171120
  201. Song H, Wohltmann M, Bao S, Ladenson J, Semenkovich CF, & Turk J. Mice deficient in Group VIB Phospholipase A2 (iPLA2γ) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western Diet. J. Physiol. Endocrinol. Metab. 2010; 298: E1097–E1114. PMID: 20179248
  202. Dietrich HH, Abendschein DR, Nayeb-Hashemi N, Mancuso DJ, Jenkins CM, Kaltenbronn KM, Blumer KJ, Turk J, & Gross Knockout of calcium-independent phospholipase A2b attenuates endothelium-dependent relaxation induced by acetylcholine. Am. J. Physiol. Heart and Lung 2010; 298: H2208-20. PMID: 20382858
  203. Lamerz AC, Damerow S, Kleczka B, Wiese M, van Zandbergen G, Lamerz J, Wenzel A, Hsu FF, Turk J, Beverley SM, & Routier FH. Deletion of UDP-Glucose Pyrophosphorylase reveals a UDP-Glucose independent UDP-Galactose salvage pathway in Leishmania major. Glycobiology 2010; 20: 872–882. PMID: 20335578
  204. Sevova ES, Goren MA, Schwartz KJ, Hsu FF, Turk J, Fox BG, & Bangs JD. Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic Trypanosomatid J. Biol. Chem. 2010; 285:20580-20587. PMID: 20457606
  205. Zhao Z, Zhang X, Zhao C, Choi J, Shi J, Song K, Turk J, & Ma ZA. Protection of pancreatic β-cells by group VIA phospholipase A2-mediated repair of mitochondrial membrane peroxidation. Endocrinology 2010; 151: 3038-48. PMID: 20463052.
  206. Sharma J, Turk J, & McHowat J. Endothelial cell Prostaglandin I2 and Platelet-Activating Factor production are markedly attenuated in the calcium-independent Phospholipase A2β knockout mouse. Biochemistry 2010; 49: 5473-81. PMID: 20521843
  207. Schneider JG, Yang Z, Chakravarthy MV, Lodhi IJ, Wei1 X, Turk J, and Semenkovich CF. Macrophage fatty acid synthase deficiency decreases diet-induced atherosclerosis. Biol. Chem. 2010; 285: 23398-23409. PMID: 20479009
  208. Li H, Zhao Z, Wei G, Yan L, Wang D, Zhang H, Turk J, & Xu Y. Both host and tumor cell group VIA phospholipase A2 are involved in ovarian cancer development. FASEB J. 2010; 24: 4103-4116. PMID: 20530749
  209. Basselin M, Rosa AO, Ramadan E, Cheon Y, Chang L, Chen M, Greenstein D, Wohltmann M, Turk J, & Rapoport SI. Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2β (VIA)-deficient mice. Lipid Res. 2010; 51: 3166-73. PMID: 20686114
  210. Hsu FF, Turk J. Toward total structural analysis of cardiolipins: Multiple-stage linear ion-trap mass spectrometry of the [M-2H+3Li]+ J. Am. Soc. Mass Spectrom. 2010; 21: 1863-9. PMID: 20692852
  211. Song H, Rohrs H, Tan M, Wohltmann M, Ladenson JH, & Turk J. Effects of ER stress on Group VIA PLA2 (iPLA2b) in beta cells include tyrosine phosphorylation and increased association with calnexin. Biol. Chem. 2010; 285: 33843-57. PMID: 20732873
  212. Hsu FF, Soehl K, Turk J, Haas A. Characterization of mycolic acids from the pathogen Rhodococcus equi by tandem mass spectrometry with electrospray ionization. Biochem. 2011; 409: 112-122. PMID: 20946862
  213. Sharma J, Turk J, Mancuso DJ, Sims HF, Gross RW, & McHowat J. Activation of Group VI phospholipase A2 isoforms in cardiac endothelial cells of wild type and knockout mice. J. Physiol. Cell Physiol. 2011; 300: C872-9. PMID: 2119110
  214. McHowat J, Gullickson G, Hoover RG, Sharma J, Turk J, & Kornbluth J. Platelet-activating factor and metastasis: Calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung. J. Physiol. Cell Physiol. 2011; 300: C825-32. PMID: 21228317
  215. Xu M, Wang WF, Frontera JR, Neely MC, Lu JJ, Aires D, Hsu FF, Turk J, Swerdlow RH, Carlson SE, & Zhu H. Ncb5or deficiency increases fatty acid catabolism and oxidative stress Biol. Chem. 2011; 286: 11141-54. PMID: 21300801
  216. Akhtar K, Broekelmann TJ, Song H, Turk J, Brett TJ, Mecham RP, Adair-Kirk TL. Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding. Biol. Chem. 2011; 286: 13574-82. PMID: 21321118
  217. Wang W, Guo Y, Xu M, Huang HH, Novikova L, Larade K, Jiang ZG, Thayer TC, Frontera JR, Aires D, Ding H, Turk J, Mathews CE, Bunn HF, Stehno-Bittel L, & Zhu H. Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells. Biophys. Acta. 2011; 1812: 1532-1541. PMID: 21839170.
  218. Rhoades ER, Streeter C, Turk J, & Hsu FF. Characterization of Mycobacterium tuberculosis H37Rv sulfolipid molecular species structures by multiple-stage linear ion-trap high resolution mass spectrometry with electrospray ionization reveals that sulfolipid II family members predominate. Biochemistry 2011; 50: 9135-47. PMID: 21919534.
  219. Hsu FF, Wohlmann J, Turk J, & Haas A. Structural definition of trehalose 6-monomycolates and trehalose 6,6′-dimycolates from the pathogen Rhodococcus equi by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2011; 22: 2160-70. PMID: 21972013.
  220. Xie Z, Liu D, Liu S, Kavanagh L, Zhao G, Turk J, & Guo Z. Identification of a cAMP-response element in the RGS2 Promoter as a key cis-regulatory element for RGS2 transcriptional regulation in vascular smooth muscle cells. Biol. Chem. 2011; 286: 44646-58. PMID: 22057271
  221. Sharma J, Young DM, Marentette JO, Rastogi P, Turk J, & McHowat J. Lung endothelial cell Platelet Activating Factor production and adherence to inflammatory cells increase upon exposure to cigarette smoke components. J. Physiol. Lung Cell. Mol. Physiol. 2012; 302: L47-55. PMID: 21984569
  222. Tatituri RV, Brenner MB, Turk J, & Hsu FF. Structural elucidation of diglycosyl diacylglycerol and monoglycosyl diacylglycerol from Streptococcus pneumoniae by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Mass Spectrom. 2012; 47: 115-23. PMID: 22282097
  223. Song H, Wohltmann M, Tan M, Bao S, Ladenson JH, & Turk J. Group VIA phospholipase A2 (iPLA2β) is activated upstream of p38 MAP kinase in pancreatic islet beta cell signaling. Biol. Chem. 2012; 287: 5528-41. PMID: 22194610
  224. Guo Y, Xu M, Deng B, Frontera JR, Kover KL, Aires D, Carlson SE, Ding H, Turk J, Wang WF, & Zhu H. Beta cell injury in Ncb5or-null mice is exacerbated by consumption of a high fat diet despite near normalization of body weight. J. Lipid Sci. Technol., 2012; 114: 233–243. PMID: 22582025. PMCID: PMC3348618.
  225. Cheona Y, Kim HW, Igarashi M, Modia HR, Chang L, Ma K, Greenstein D, Wohltmann M, Turk J, Rapoport SI, Ameer Y, & Taha AY. Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A2-VIA (iPLA2β)-knockout mice. Biophys. Acta. 2012; 1821: 1278-86. PMID: 22349267
  226. Liu S, Xie Z, Zhao Q, Pang H, Turk J, Calderon L, Su W, Zhao G, Xu H, Gong MC, & Guo Z. Smooth muscle-specific expression of iPLA2β participates in the initiation and early progression of vascular inflammation and neointima formation. Biol. Chem. 2012; 287: 24739-53. PMID: 22637477
  227. Hsu FF, Pacheco S, Turk J, & Purdy G. Structural determination of glycopeptidolipids of Mycobacterium smegmatis by high-resolution multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Mass Spectrom. 2012; 47: 1269-81. PMID: 23019158
  228. Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Hsu FF, Turk J, & Semenkovich CF. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Cell Metab. 2012; 16: 189-201. PMID: 22863804
  229. Bao S, Song H, Tan M, Wohltmann M, Ladenson JH, Turk J. Group VIB phospholipase A2 promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents. Med. Cell. Longev. 2012; 2012: 989372. PMID: 23213352
  230. Zhu T, Chappel JC, Hsu FF, Turk J, Aurora R, Hyrc K, De Camilli P, Broekelmann TJ, Mecham RP, Teitelbaum SL, & Zou W. Type I phosphotidylinosotol-4 phosphate 5 kinase γ regulates osteoclasts in a bifunctional manner. Biol. Chem. 2013; 288: 5268–5277. PMID: 23300084
  231. Palanker-Musselman L, Fink JL, Ramachandran PV, Patterson BW, Okunade AL, Maier E, Brent M, Turk J, & Baranski TJ. Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. Biol. Chem. 2013; 288: 8028-42. PMID: 23355467
  232. Hsu FF, Lobasso S, Turk J, & Corcelli A. Structural studies on archaeal phytanyl-ether lipids isolated from membranes of extreme halophiles by linear ion-trap multiple-stage tandem mass spectrometry with electrospray ionization. Chim. Acta 2013; 771: 73-85. PMID: 23522115
  233. Lei X, Bone RN, Ali T, Wohltmann M, Gai Y, Goodwin KJ, Bohrer AE, Turk J, & Ramanadham S. Genetic modulation of islet β-cell iPLA2β expression provides evidence for its impact on β-cell apoptosis and autophagy. Islets 2013; 5: 29-44. PMID: 23411472
  234. Chen A, Tang Y, Davis V, Hsu FF, Kennedy SM, Song H, Turk J, Brunt EM, Newberry EP, & Davidson NO. Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet induced nonalcoholic fatty liver disease. Hepatology 2013; 57: 2202-12. PMID: 23401290
  235. Rector RS, Morris EM, Ridenhour S, Meers GM, Hsu FF, Turk J, & Ibdah JA. Selective hepatic insulin resistance in mice heterozygous for a mitochondrial trifunctional protein defect. Hepatology 2013; 57: 2213-23. PMID: 23359250
  236. Purdy G, Pacheco S, Turk J, & Hsu FF. Characterization of mycobacterial triacylglycerols and the unusual monomeromycolyl diacylglycerols from Mycobacterium smegmatis biofilm by linear ion-trap multiple-stage and high-resolution mass spectrometry with electrospray ionization. Bioanal. Chem. 2013; 405: 7415-26. PMID 23852148.
  237. Sharma J, Eickhoff CS, Hoft DF, Turk J, Marintette J, & McHowat J. Absence of calcium-independent phospholipase A2β impairs PAF production and inflammatory cell recruitment in Trypanosoma cruzi-infected endothelial cells. Rep. 2014; 2: e00196. PMID: 24744875. PMCID: PMC3967679.
  238. Hsu FF, Kuhlmann M, Turk J, & Beverley SM. Multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chains in Leishmania infantum. Mass Spectrom. 2014; 49: 201-9. PMID: 24619546. PMCID: PMC4007172.
  239. Tan C, Day R, Bao S, Turk J, & Zhao QD. Group VIA Phospholipase A2 mediates enhanced macrophage migration in diabetes mellitus by increasing expression of NADPH Oxidase 4. Thromb. Vasc. Biol. 2014; 34: 768-78. PMID 24482376. PMCID: PMC3966950.
  240. Song H, Wohltmann M, Tan M, Ladenson JH, & Turk J. Group VIA Phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis. Biol. Chem. 2014; 289: 14194-14210.PMID: 24648512. PMCID: PMC4022886.
  241. Hsu FF, Lodhi IJ, Turk J, & Semenkovich CF. Structural distinction of diacyl-, alkylacyl, and alk-1-enylacyl glycerophosphocholines as [M-15]- ions by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Am. Soc. Mass Spectrom. 2014; 25: 1412-20. PMID: 24781459. PMCID: PMC4331342.
  242. Blanchard H, Taha AY, Cheon Y, Kim H, Turk J, & Rapoport SI. iPLA2β knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology. Res. 2014; 39: 1522-32. PMID: 24919816. PMCID: PMC4364003
  243. Tatituri R, Wolf B, Brenner M, Turk J, Hsu FF. Characterization of polar lipids of Listeria monocytogenes by HCD and low energy CAD linear ion-trap mass spectrometry with electrospray ionization. Bioanal. Chem. 2015; 407: 2519-28. PMID: 25656850. PMCID: PMC4368491.
  244. Thimgan MS, Seugnet L, Turk J & Shaw PJ. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Sleep 2015; 38 (5): 801-814. PMID: 25409104. PMCID: PMC4402663
  245. Paran CW, Verkerke ARP, Heden TD, Park S, Zou K, Lawson HA, Song H, Turk J, Houmard JA, Funai K. Reduced efficiency of sarcolipin-dependent respiration in myocytes from severely obese humans. Obesity 2015; 23 (7): 1440–1449. PMID: 25970801. PMCID: PMC4483165
  246. Paran CW, Zou K, Ferrara PJ, Song H, Mendias CL, Turk J, Funai K. Lipogenesis mitigates dysregulated SR calcium uptake in muscular dystrophy. Biochim Biophys Acta. 2015; 1851 (12): 1530-8. PMID: 26361872. PMCID: PMC4619134.
  247. Flentie KN, Stallings C‎, Turk J‎, Minnaard AJ, Hsu FF. Characterization of phthiocerol and phthiodiolone dimycocerosate esters of tuberculosis by multiple-stage linear ion-trap mass spectrometry. J. Lipid Res. 2016; 57 (1): 142-155. PMID: 26574042.
  248. Abi Nahed R, Martinez G, Escoffier J, Yassine S, Karaouzène T, Hograindleur JP, Turk J, Kokotos G, Ray PF, Bottari S, Lambeau G, Hennebicq S, Arnoult C. Progesterone-induced acrosome exocytosis requires sequential involvement of calcium-independent iPLA2b and group X sPLA2. J. Biol. Chem. 2016; 291 (6): 3076-89. PMID: 26655718.
  249. Sharma J, Blasé J, Hoft D, Marentette J, Turk J, McHowat J. Mice with genetic deletion of group VIA phospholipase A2 (iPLA2β) exhibit impaired inflammatory cell function and increased parasite load in Trypanosoma cruzi-induced myocarditis. Immun. 2016; 84 (4): 1137-1142. PMID: 26857573.
  250. Karner CM, Esen E, Chen J, Hsu FF, Turk J, Long F. WNT signaling reduces nuclear acetyl-coA levels to suppress gene expression during osteoblast differentiation. Biol. Chem. 2016; 291 (25): 13028-39. PMID: 27129247.
  251. Ashley JW, Hancock WD, Nelson AJ, Bone RN, Tse HM, Wohltmann M, Turk J, & Ramanadham S. Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2β. Biol. Chem. 2016; 291 (44): 23268-23281. PMID: 27650501

Reviews, Case Reports, Invited Publications

  1. Marshall G, Bosshard H, Kendrick N, Turk J, Balasubramanian T, Cobb MH, Moore M, LeDuc L & Needleman P: Alpha-methyl amino acids in peptide chemistry. In Peptides 1976 (Loffet A, ed.), Editions del Universite de Bruxelles, Brussels, 1976; 361-64.
  2. Turk J, Dietzler D, & Weidner N: Theophylline toxicity. (McDonald J & Ladenson J, eds.) Chem. 1978; 24: 1603-1608. PMID: 357040
  3. Turk J & Needleman P: Coronary prostacyclin synthesis and its modulation by interactions with platelets. In Acetylsalicylic Acid: New Uses for an Old Drug. (Barnett HJM, Hirsh J, and Fraser-Mustard J, eds.) Raven Press, New York, 1982; 165-174.
  4. Turk J, Maas R, Roberts L, Brash A, & Oates J: Conjugated triene metabolites of arachidonic acid derived from carbon-15 dioxygenation: Origin from eosinophils and biosynthetic mechanisms. Prost. Thromb. Leukotr. Res. 1983; 11: 23-132. PMID: 6221514
  5. Turk J & Ladenson JH. Phenytoin and phenobarbital concentrations in renal insufficiency. Intern. Med. 1984; 101: 569. PMID: 6476648
  6. Needleman P, Turk J, Jakschik B, Morrison A, & Lefkowith J: Arachidonic Acid Metabolism. Rev. Biochem. 1986; 55: 69-102. PMID: 3017195
  7. Turk J, Morrell L, & Avioli LV: Ethylene glycol intoxication. Int. Med. 1986; 146: 1601-1603. PMID: 3729644
  8. Wolf BA, Turk J, Comens PG, Sherman WR, & McDaniel ML: Arachidonic acid mobilizes intracellular Ca2+ in islets. N.Y. Acad. Sci. 1987; 494: 168-170. (US: http://dx.doi.org/10.1111/j.1749-6632.1987.tb29513.x)
  9. Turk J, Wolf BA, & McDaniel ML: The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol trisphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancreatic islets. Lipid Res. 1987; 26: 125-181. PMID: 3116559
  10. McDaniel ML, Wolf BA, Landt M, Easom RA, & Turk J: Evidence for a role of protein phosphorylation involving a Ca2+/calmodulin-dependent protein kinase and protein kinase C in the insulin secretory process. Diabetes 1988 (R.G. Larkins, P.Z. Zimmet, and D.J. Chisholm, eds.), pp. 391-395, Elsevier Science Publishers, B.V., Amsterdam (1988).
  11. McDaniel ML, Wolf BA, & Turk J: Signal transduction and insulin secretion. Roles of intracellular Ca2+, inositol trisphosphate, and arachidonic acid. Clin. Biol. Res. 1988; 99-116. PMID: 3136457
  12. Turk J: Testing for drugs of abuse in urine. Missouri Medicine 1989; 86: 337-340. PMID: 2755453
  13. Turk J, Wang J-L, Corbett J, Ramanadham S, Wolf BA, Easom RA, & McDaniel ML: Secretagogue-induced diacylglycerol accumulation and protein kinase C activation in beta cell function. Pages 161-164, in Diabetes 1991 (Rifkin H, Colwell JA, and Taylor SI, Eds.), Elsevier Science Publishers, B.V., Amsterdam (1991).
  14. Lorenz RG, Garrett N, Turk J, & Scott MG. Problems with therapeutic monitoring of cyclosporine using silicone central venous line samples. Transplantation 1991; 52: 1109-10. PMID: 175007
  15. Chan K-M, Matthews WS, & Turk J: Emergency Toxicology and Drugs of Abuse Testing, in Clinical Chemistry, 157-171 (A.H.B. Wu, ed.), Health and Education Resources, Inc., Bethesda, Maryland (1991).
  16. Hryhorczuk DO, Aks S, & Turk J: Unusual occupational toxins. State of the Art Reviews in Occupational Medicine 1992; 7: 567-586. PMID: 1496435
  17. Turk J, Gross R, & Ramanadham S. Phospholipid hydrolysis in pancreatic islet beta cells and the regulation of insulin secretion. Pages 215-239 in Advances in Lipobiology, Volume 1 (Gross R, ed.) JAI Press Inc., Greenwich, CT (1996).
  18. Ma Z & Turk J. The molecular biology of the Group VIA Ca2+-independent phospholipase A2. Nucl. Acid Res. Molec. Biol. 2001; 67: 1-33 (Moldave K, ed.), Academic Press, San Diego, CA. PMID: 1152538
  19. Turk J & Ramanadham S. Expression and function of Group VIA Phospholipase A2 (iPLA2b) in b-cells. Can J. Physiol. Pharmacol. 2004; 82: 824-832. PMID: 15573142
  20. Hsu FF & Turk J. Mechanisms for phospholipid fragmentation in electrospray ionization mass spectrometry with collision-induced dissociation. In Modern Methods for Lipid Analysis by Liquid Chromatography-Mass Spectrometry and Related Techniques (WC Byrdwell, ed.), pp. 61-179, American Oil Chemists Society Press, Champaign, IL (2005)
  21. Hsu FF & Turk J. Tandem quadrupole mass spectrometry of sulfatides. In The Encyclopedia of Mass Spectrometry, Volume 3: Biological Applications, Part B. Carbohydrates, Nucleic Acids, and other Biological Compounds (Caprioli R & Gross ML, eds.), pp. 473-492, Elsevier Ltd., Oxford, UK (2006).
  22. Turk J, Bao S, & Ramanadham S. Lipid messengers from a phospholipase A2 enzyme and b-cell biology. In Commentaries on Perspectives in Diabetes, Vol. 2 (1993-1997) (Robertson RP, ed.), pp. 10-20, American Diabetes Association, Alexandria, VA (2006).
  23. Hsu FF & Turk J. Tandem quadrupole mass spectrometry of sphingomyelin. In The Encyclopedia of Mass Spectrometry. Volume 3: Biological Applications, Part B. Carbohydrates, Nucleic Acids, and other Biological Compounds (Caprioli R & Gross ML, eds.), pp. 430-437, Elsevier Ltd., Oxford, UK (2006).
  24. Song H, Ladenson J, & Turk J. Algorithms for automatic processing of data from mass spectrometric analyses of lipids. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009; 877: 2847–2854. PMID: 19131280
  25. Hsu FF & Turk J. Electrospray ionization with low-energy collisionally activated dissociation tandem mass spectrometry of glycerophospholipids: Mechanisms of fragmentation and structural characterization. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009; 877: 2673-95. PMID: 19269264
  26. Ma ZA, Zhao Z, & Turk J. Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus. Diabetes Res. 2012; 2012: 703538. PMID: 2110477

Manuscripts under review

  1. Lin MH, Miner JH, Turk J, & Hsu FF. Linear ion-trap MSn with high resolution mass spectrometry reveals structural diversity of an epidermal 1‐O‐acyl ceramide family in mice. Lipid. Res., manuscript JLR/2016/071647, under review (2017)


Assistant
Suzi Schumacher
314-362-2602
s.schumacher@wustl.edu

Lab Phone: 314-362-7878
Office Location: 855 SW Tower