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ILKe Nalbantoglu, MD

Assistant Professor, Pathology & Immunology




  • BS: Ege University School of Medicine, Izmir, Turkey (2000)
  • Medical Degree: Ege University School of Medicine, Izmir, Turkey (2000)

Board Certifications

  • Missouri Medical License
  • Michigan Medical License
  • Georgia Educational Limited License
  • Illinois Medical License
  • The American Board of Pathology Certification in Anatomic and Clinical Pathology


  • 11/2006 Recipient of Letter of Acknowledgement for Excellent Service
  • 05/2007 Recipient of Letter of Acknowledgement for Excellent Service
  • 05/2007 Resident Instructor Award
  • 04/2008 Second place, Residents Research Day
  • 05/2008 Certificate for Excellence in Research

Clinical Interests

  • Liver/Gastrointestinal Pathology


Saidi RF, Chang J, Verb S, Brooks S, Nalbantoglu I, Adsay V, Jacobs MJ. The effect of methyprednisolone on warm ischemia-reperfusion injury in the liver. Am J Surg 2007: 193(3):345-347; discussion 347-348. PMID:17320532
Saidi RF, Ahad A, Escobar R, Nalbantoglu I, Adsay V, Jacobs MJ. Comparison between staple and vessel sealing device for parynchemal transection in laparoscopic liver surgery in a swine model. The Official Journal of the International Hepato Pancreato Biliary Association, HPB (Oxford) 9(6):440-443, 2007. PMID:1834529
Saidi RF, Chang J, Brooks S, Nalbantoglu I, Adsay V, Jacobs, MJ. Ischemic preconditioning and intermittent clamping increase the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat. Transplant Proc 2007: 39(10):3010-3014. PMID:1808931
Doganavsargil B, Nalbantoglu I, Hekimgil M. Handling and reporting of radical prostatectomy specimens: a practice survey among pathologists. Turkish Journal of Pathology 2007: 23(2):74-81.
Jacob JB, Kong YC, Nalbantoglu I, Snower DP, Wei WZ. Tumor regression following DNA vaccination and regulatory T cell depletion in neu transgenic mice leads to an increased risk of autoimmunity. J Immunol 2009: 182(9):5873-5881, 2009. PMID:19380836
Carvalho FA, Nalbantoglu I, Aitken JD, Uchiyama R, Su Y, Doho GH, Vijay-Kumar M, Gewirtz AT. Cytsolic flagellin receptor NLRC4 protects mice against mucosal and system challenges. Mucosal Immunol 2012: 5(3):288-298. PMID:22318495
Saidi RF, Ahad A, Tilak J, Nalbantoglu I, Jacobs MJ. The expression of interferon receptor α/ß in human pancreatic cancer in nude mice is essential for tumor response to interferon α treatment. J Surg Res 2012: 173(2):309-313. PMID:21067774
Dehdashti F, Grigsby PW, Myerson RJ, Nalbantoglu I, Ma C, Siegel BA. Positron emission tomography with [18F]-3′-deoxy-3’fluorothymidine (FLT) as a predictor of outcome in patients with locally advanced resectable rectal cancer: a pilot study. Mol Imaging Biol 2013: 15(1):106-113. PMID:22684813
 Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, Gewirtz AT. Interleukin-1ß (Il-1ß) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 2012: 61(3):373-384. PMID:21646247
 Bokshan SL, Doyle M, Becker N, Nalbantoglu I, Chapman WC. Hepatic hemangiopericytoma/solitary fibrous tumor: a review of our current understanding and case study. J Gastrointest Surg 2012: 16(11):2170-2176. PMID:22854953
 Carvalho FA, Koren O, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT. Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe 2012: 12(2):139-152. PMID:22863420
 Xie Y, Matsumoto H, Nalbantoglu I, Kerr TA, Luo J, Rubin DC, Kennedy S, Davidson NO. Intestine-specific Mttp deletion increases the severity of experimental colitis and leads to greater tumor burden in a model of colitis associated cancer. PLoS ONE 2013: 8(6):e67819. PMID:23805328
 Dharmarajan S, Newberry EP, Montenegro G, Nalbantoglu I, Davis VR, Clanahan MJ, Blanc V, Xie Y, Luo J, Fleshman JW Jr, Kennedy S, Davidson NO. Liver fatty acid-binding protein (L-Fabp) modifies intestinal fatty acid composition and adenoma formation in ApcMin/+ mice. Cancer Prev Res (Phila) 2013: 6(10):1026-1037. PMID:23921281
 Nalbantoglu I, Brunt EM. Role of liver biopsy in nonalcoholic fatty liver disease. World J Gastroenterol 2014: 20(27):9026-9037. PMID:25083076
 Nalbantoglu I, Tan BR Jr, Linehan DC, Gao F, Brunt EM. Histologic features and severity of exaliplatin-induced liver injury and clinical associations. J Dig Dis, July 2014, [Epub ahead of print]. PMID:25060628
 Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res 2014: 74(18):5322-35. PMID: 25085247
 Kushnir VM, Nalbantoglu I, Watson R, Goodwin J, Safar E, Chokshi RV, Azar RR, Davidson NO. Advanced Colorectal Adenomas in Patients Under 45 Years of Age Are Mostly Sporadic. Dig Dis Sci 2014: 59(11):2757-64. PMID: 24925148
 Zhang C, Zhao Z, Osman H, Watson R, Nalbantoglu I*, Lin J. Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. Microrna 2014: 3(3):155-9. PMID:25665881 (*Shared senior author)
 Lin J, Cummings OW, Greenson JK, House MG, Liu X, Nalbantoglu I, Pai R, Davidson DD, Reuss SA. IgG4-related sclerosing cholangitis in the absence of autoimmune pancreatitis mimicking extrahepatic cholangiocarcinoma. Scand J Gastroenterol 2015: 50(4):447-453. PMID:25635498
 Osman H, Watson R, Fan R, Nalbantoglu I, Lin J. Intermittent Inflammatory Bowel Disease and Microscopic Colitis: Variant or Epiphenomenon? Gastroenterology and Hepatology 2015: 2(1):1-7. DOI: 10.3968/5288
 Majella-Doyle MB, Collins K, Vaccharajani N, Lowell JA, Shenoy S, Nalbantoglu I, Byrnes K, Garonzik-Wang J, Wellen J, Lin Y, Chapman WC. Outcomes Using Grafts from Donors after Cardiac Death. J Am Coll Surgery 2015: 221(1):142-152. PMID: 26095563
 Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu T-C, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SW, Yeh MM, Ferrell LD. Hepatic Small Vessel Neoplasm, a Rare Infiltrative Vascular Neoplasm of Uncertain Malignant Potential. Human Pathology 2016: 54(143-151)
 Watson RF, Osman H, Aranake-Chrisinger J, JM Lin JM, Nalbantoglu I. Alternating Phases of Inflammatory Bowel Disease and Microscopic Colitis: A phenotypic switch? Clinicopathologic and Immunohistochemical Features, Scandinavian Journal of Gastroenterology, submitted.
 Pehlivanoglu B, Doganavsargil B, Sezak M, Nalbantoglu I, Korkmaz M. Gastrointestinal Parasitosis: Histopathological Insights to Rare but Intriguing Lesions of the Gastrointestinal Tract. Turkish Journal of Pathology 2016: 32(2):082-090. DOI: 10.5146/tjpath.2015.01350
 Nalbantoglu I, Brunt EM. GI Tract. The Intestines, Appendix and Anus. In Humphrey, Dehner, Pfeifer (eds). The Washington Manual of Surgical Pathology, 2nd ed, Wolters Kluwer, 2012, p214-247.
 Nalbantoglu I, Blanc V, Davidson N, Characterization of colorectal cancer development in Apc min/+ mice, Methods in Molecular Biology, in press
 Nalbantoglu I. Histologic Features Predict Crohn’s Disease Recurrence. PracticeUpdate website. Available at: Accessed March 5, 2015.


Julie L. Gutierrez

Office Location: BJC-IH Building, Room 3419