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Guoyan Zhao, PhD

Assistant Professor, Pathology & Immunology
Director, Pathogen Discovery Facility


Research Interests

The focus of the Pathogen Discovery Facility is identification of new agents of human disease. Currently, the etiologies of many human diseases are unknown, but may be infectious. New viruses can enter the human population with devastating effect, and the intentional release of new or engineered agents is a danger. We apply cutting edge next-generation sequencing technology and computational analysis to identify novel as well as known viruses from patient specimens. Identification of novel viral agents will serve as the starting point for additional studies focused on demonstrating disease causality and dissecting mechanisms of viral pathogenesis.


Pub Med Search

Zhao G, Ihuegbu N, Lee M, Schriefer L, Wang T, Stormo GD.. Conserved Motifs and Prediction of Regulatory Modules in Caenorhabditis elegans.. G3 (Bethesda). 2(4):469-81., 2012 Abstract
Zhao G, Handley SA, Thackray LB, Presti R, Miller AD, Droit L, Abbink P, Maxfield LF, Kambal A, Duan E, Stanley K, Kramer J, Macri SC, Permar SR, Schmitz JE, Mansfield K, Brenchley JM, Veazey RS, Stappenbeck TS, Wang D, Barouch DH, Virgin HW.. Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome.. Cell. 151(2):253-66., 2012 Abstract
Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D..Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes.. Virology. doi:pii: S0042-6822(12)00492-8., 2012 Abstract
Zhao G, Droit L, Tesh RB, Popov VL, Little NS, Upton C, Virgin HW, Wang D.. The genome of Yoka poxvirus.. J Virol. 85(19):10230-8, 2011 Abstract
Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pimentel G, Dueger E, Pipas J, Girones R, Wang D, and Virgin HW. Detection of novel sequences related to African Swine Fever virus in human serum and sewage. Journal of Virology 83(24):13019-25, 2009Abstract
Presti RM, Zhao G, Beatty WL, Mihindukulasuriya KA, Travassos da Rosa APA, Popov VL, Tesh RB, Virgin HW, Wang D. Quaranfil, Johnston Atoll and Lake Chad viruses are novel members of the family Orthomyxoviridae. Journal of Virology, 83(22):11599-606, 2009 Abstract
Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas J and Wang D. Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virology Journal 6:86, 2009 Abstract
Missiuro PV, Liu K, Zou L, Ross BC, Zhao G, Liu JS, Ge H.. Information flow analysis of interactome networks. PLoS Computational Biology, 5(4):e1000350, 2009 Abstract
Zhao, G., Chang, K.Y., Varley, K. and Stormo, G.D.. Evidence for active maintenance of inverted repeat structures identified by a comparative genomic approach. PLoS One. 2(2):e262., 2007Abstract
Zhao, G., Wheeler, S.R. and Skeath, J.B.. Genetic control of dorsoventral patterning and neuroblast specification in the Drosophila Central Nervous System.. Int J Dev Biol. 51(2):107-15., 2007Abstract
Zhao G, Schriefer L, Stormo GD. Identification of muscle-specific regulatory modules in Caenorhabditis elegans. Genome Research 17(3): 348-57, 2007 Abstract
Zhao G, Boekhoff-Falk G, Wilson BA, Skeath JB. Linking pattern formation to cell-type specification – Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS. Proc. Natl. Acad. Sci. USA. 104(10): 3847-52, 2007 Abstract
Zhao, G. and Skeath, J.B.. The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm.. Development. 129(5):1165-74, 2002 Abstract

Lab Phone: 314-454-8772
Office Location: West Building, Room 4724