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Donald Conrad, PhD

Associate Professor, Pathology & Immunology
Associate Professor, Genetics (dual)

Phone314-362-4379

Emaildon.conrad@wustl.edu

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Education

  • AB, Biochemistry and Molecular Biology: Dartmouth College, Hanover, NH (1999)
  • MSc, Epidemiology: Stanford University School of Medicine, Stanford, CA (2000)
  • PhD: University of Chicago, Chicago, IL (2007)
  • Postdoctoral Fellow: Wellcome Trust Sanger Institute, Cambridge, UK (2010)

Recognition

  • Fulbright Specialist Grant (2017)
  • Finalist for Postdoctoral Trainee (Basic) award, ASHG (2008)
  • Best Dissertation in Biological Sciences (honorable mention), U of Chicago (2008)
  • Outstanding Performance Award, Human Genetics, U of Chicago (2008)
  • Dartmouth Alumni Fund Scholarship (1998)
  • Green Key Junior Class Honor Society (Peer-elected position) (1997)

Research Interests

Our research is currently organized around several major themes.

  1. Variation in human chromosome structure.  We have played a leading role in mapping and characterizing the functional impact of structural variants (“SVs”: deletions, duplications, inversions, and more complex rearrangements) over the past 7 years. As the map of common SVs is growing more and more complete, we are now moving towards functional analysis of SV as a class (ie by describing their impact on global gene expression) as well as testing hypotheses regarding individual SVs that show striking evidence for being subject to adaptive evolution.
  2. The causes of new mutation, and variation in mutation rate, both within and among individuals.  Our work on mapping breakpoints of CNVs and rare aneuploidies has provided new insights to the formation of chromosome rearrangements. Most recently, we have developed novel statistical methods for identifying de novo point mutations from next-generation sequencing data, and used this to estimate germ line mutation rates from parent-offspring trios as part of the 1000 genomes project. We would like to continue developing these tools to handle more complex forms of mutation and arbitrary pedigree structure.
  3. Human reproduction. Reproduction is a natural biological system to approach from a genetics background – many open questions pertaining to the origins of mutation and the distribution of mutation frequencies will require an investigation of gametogenesis, fertilization, and pregnancy.  The lab has a number of projects ongoing in this area covering topics such as the biology of spermatogenesis and the placenta. We are trying to facilitate genetic medicine through this work and are eager to collaborate with clinicians in this area.

Editorial Responsibilities

2014-Present Editorial Board Genome Research
2013-Present Editorial Board Biology of Reproduction
2012-Present Editorial Board Andrology
Present Ad Hoc Reviewer Nature, Science, American Journal of Human Genetics, Andrology, Bioinformatics, Biological Psychiatry, Biology of Reproduction, BMC Biology, Briefings in Functional Genomics, Cell & Tissue Research, Chromosome Research, CSH Protocols, EMBO Molecular Medicine, European Journal of Human Genetics, Fertility and Sterility, Forensic Science International: Genetics, Genetics, Genome Biology, Genome Research, Human Heredity, Human Molecular Genetics, Human Mutation, Journal of Clinical Investigation, Journal of Pharmacogenomics, Molecular Biology and Evolution, Molecular Ecology, Nature Communications, Nature Genetics, Nature Methods, Nature Reviews Genetics, Neurogenetics, Pediatrics, PLoS Genetics, PLoS ONE, PNAS, Systems Biology in Reproductive Medicine, Trends in Genetics

Publications

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