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Chih-Hao (Lucas) Chang, PhD

Instructor, Pathology & Immunology



  • MS: Oxford University, United Kingdom (2004)
  • PhD: Oxford University, United Kingdom (2010)

Research Interests

Metabolism is the set of biochemical reactions that occur within cells to sustain life. As such, metabolism, by definition, remains the single most fundamental force driving cell fate. I am interested in understanding the cellular and molecular mechanisms that control T cell fate and function during cancer development.

Editorial Responsibilities

2016-2017 Lead Guest Editor Oxidative Medicine and Cellular Longevity

Service to the Department

2015-present Research Instructor


PubMed Search

Chang CH, Pearce EL. (2016) Emerging concepts of T cell metabolism as a target for immunotherapy. Nature Immunology, 17(4):364-368. PubMed: 27002844
Buck MD, O’Sullivan D, Geltink RIK, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJW, Chen Q, Huang SC, O’Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. (2016) Mitochondrial dynamics controls T cell fate through metabolic programming. Cell, 166(1):63-76. PubMed: 27293185
Chang CH, Qiu J, O’Sullivan D, Buck MD, Noguchi T, Curtis JD, Gindin M, Chen Q, Gubin MM, Tonc E, van der Windt GJ, Schreiber RD, Pearce EJ, Pearce EL. (2015) Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell, 162(6):1229-41. PubMed: 26321679
Chang CH, Kist N, Chester TLS, Sreenu VB, Herman M, Luo M, Lunn D, Bell J, Plummer FA, Ball TB, Katzourakis A, Iversen AK. (2015) HIV-infected patients with beneficial HLA variants are potential hubs for selection of HIV-1 recombinants that may affect disease progression. Scientific Reports, 5:11253. PubMed: 26082240
Chang CH, Curtis JD, Maggi LB, Faubert B, Villarino AV, O’Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL. (2013) Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell, 153:1239-1251. PubMed: 23746840
Pearce EL, Poffenberger E, Chang CH, Jones RG. (2013) Fueling Immunity: Insights into Metabolism and Lymphocyte function. Science, 342:1242454. PubMed: 24115444

Lab Phone: 314-286-2361
Office Location: BJC-IH Building, Room 8307