See all

Ann M Gronowski, PhD

Professor, Pathology & Immunology
Medical Co-Director, Clinical Chemistry



Additional Titles

  • Professor, Obstetrics and Gynecology

Related Links


  • BS, Animal Science: University of Illinois, Urbana, IL (1985)
  • MS, Nutrition Iowa State University, Ames, IA: Iowa State University, Ames, IA (1988)
  • PhD, Endocrinology and Reproductive Physiology: University of Wisconsin, Madison, WI (1992)
  • Postdoctoral Research Fellow in Endocrinology and Metabolism: Washington University School of Medicine, St. Louis, MO (1995)
  • Postdoctoral Trainee in Clinical Chemistry and Laboratory Medicine: Washington University School of Medicine, St. Louis, MO (1995)
  • Postdoctoral Research Fellow in Department of Pathology: Washington University School of Medicine, St. Louis, MO (1998)

Board Certifications

  • American Board of Clinical Chemistry


  • 1996  Young Investigator Award, AACC
  • 2010  Outstanding Contributions through Service to the Profession of Clinical Chemistry Award, AACC
  • 2011  Washington University Clinical Pathology Teaching Award
  • 2011  Mentorship Award, Society of Young Clinical Laboratorians, AACC
  • 2015  Distinguished Educator-Clinical Fellow Mentoring Award, Washington University School of Medicine
  • 2016  Outstanding Contributions through Education Award, AACC

Research Interests

My research focuses primarily on the laboratory diagnostics of endocrinology and reproductive physiology with a particular emphasis on maternal fetal medicine. Recently, our work has investigated the hormone hCG (human chorionic gonadotropin) and its variant forms. In particular, we are interested in the beta core fragment of hCG (hCGβcf) which is the predominant form of hCG in urine after five weeks of pregnancy. We have shown that high concentrations of this variant can interfere with certain pregnancy tests and cause false negative results.

We have also been studying how hCG concentrations increase with age. Although hCG is best know for its production by the placenta, it is also produced in the pituitary gland in peri-and past-menopausal women.  Our research has focused on ways to differentiate between pituitary and placental hCG.

Editorial Responsibilities

2007-Present Editorial Board Clinical Chemistry

Diagnostic Expertise

  • Immunoassays
  • Endocrinology and reproductive physiology
  • maternal fetal medicine
  • serology

Clinical Interests

  • Clinical Chemistry
  • Immunology
  • Medical & Public Health Microbiology
  • Serology


  • professor

Clinical Interest

  • chemistry
  • immunology
  • medical
  • serology


Gronowski AM, Fantz CR, Parvin CA, Sokoll LJ, Wiley C, Wener MH, Grenache DG. Use of serum FSH to identify peri-menopausal women with pituitary hCG. Clin Chem 2008;54:652-656.
Gronowski AM, Cervinski MA, Stenman U-H, Woodworth A, Ashby L, Scott MG. False negative results in point-of-care qualitative hCG devices due to excess hCG beta core fragment. 2009;Clin Chem 55:1389-1394.
Cervinski MA, Lockwood CM, Ferguson AM, Odem RR, Stenman U-H, Alfthan H, Grenache DG, Gronowski AM. Qualitative point-of–care and over-the-counter urine hCG devices differentially detect the hCG variants of early pregnancy. Clin Chem Acta: 2009;406:81-85.
Lockwood CM, Grenache DG, Gronowski AM. Serum human chorionic gonadotropin concentrations >400,000 IU/L are invariably associated with suppressed serum thyroid stimulating hormone concentrations. Thyroid 2009;19:863-868.
Gronowski AM, Powers M, Stenman U-H, Ashby LA, Scott M. False negative results from point-of-care qualitative devices due to excess hCG Beta Core fragment varies with device lot number. Clin Chem 2009;55:1885-1886.
Nerenz RD, Song H and Gronowski AM. A Screening Method to Evaluate Point-of-Care hCG Devices for Susceptibility to the Hook Effect by hCG βcf: Evaluation of Eleven Devices. Clin Chem 2014;60:667-674.
Nerenz RD, and Gronowski AM. Qualitative Point-of-Care hCG Testing: Can We Defuse This Ticking Time Bomb? Opinion. Clin Chem 2015:61:483-6.
 Nerenz RD, Butch AW, Ashby L, Woldemariam GA, Yarbrough ML, Grenache DG and Gronowski AM. Estimating the hCGβcf during pregnancy. Clin Biochem. 2016;49:282-86.

Published Books

Handbook of Clinical Laboratory Testing During Pregnancy. Ed, Gronowski AM. Humana Press, Totowa, NJ. 2004.
 Tietz Applied Laboratory Medicine, 2nd Edition. Eds., Scott MG, Gronowski AM, Eby CS. John Wiley & Sons, Inc., Hoboken, NJ. 2007.

Bio Type

  • faculty
  • trainees

Julie Shafferkoetter

Office Location: BJC-IH Building, Room 4422