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Training > Residency Program > Faculty Alphabetical > David Wang, PhD

Associate Professor, Molecular Microbiology
Associate Professor, Pathology and Immunology
McDonnell Pediatric Research Building, 8th Floor, Room 8250
Office: (314) 286-1123
Lab: (314)286-1124
E-mail: davewang@borcim.wustl.edu
Web-site: http://www.microbiology.wustl.edu/dept/fac/wang.html
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Research

Research in the Wang laboratory is situated at the interface of molecular and cellular virology, genomics and bioinformatics with the overall goal of understanding the causes of infectious diseases. As such, a major effort is dedicated to the identification of novel or unrecognized viral pathogens in both established and emerging infectious diseases. This is motivated by the fact that the etiologies of many human and animal syndromes remain cryptic; for example, ~70% of cases of viral encephalitis and ~30% of respiratory tract infections defy the most sophisticated diagnostic tests used today, suggesting that unknown agents are likely to be involved in the pathogenesis of these diseases. Furthermore, newly emerging viruses or ‘outbreaks’ such as sin nombre hantavirus (1992), nipah virus (1998) and SARS (2003) pose constant threats to public health and accentuate the need to develop novel methods for viral identification.

Toward this end, we develop and apply state of the art technologies for detection of viruses. These include pan-viral DNA microarrays and NextGen sequencing platforms aimed at identifying novel viruses present in a variety of specimen types. Ongoing research includes microarray and sequencing based pathogen identification projects in respiratory tract infections, childhood diarrhea, cancer, and acute human and animal diseases of unknown etiology. Identification of novel viral agents will serve as the launching point for additional studies focused on demonstrating disease causality and dissecting mechanisms of viral pathogenesis.

A new direction in our laboratory is the characterization of novel viruses infecting C. elegans, a robust model organism widely used in biology. Our goal is to capitalize upon our recent discovery of the first viruses known to infect C. elegans to systematically define modalities of antiviral immunity present in C. elegans.

Service to the Department

2010 - PresentAssociate Professor of Molecular Microbiology and Pathology&Immunology
2004 - 2010Assistant Professor of Molecular Microbiology and Pathology&Immunology

DBBS Graduate Program Affiliation

Computational Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Selected Publications

Felix, MA; Ashe A, et al.. Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses. PLoS Biology 9, 2011

Finkbeiner SR; Li Y; et al. Identification of a novel astrovirus (VA1) associated with an outbreak of acute gastroenteritis. J. Virol., 2009

Finkbeiner, SR; Allred, AF. Metagenomic Analysis of Human Diarrhea: Viral Detection and Discovery. PLoS Pathogens, 2008

Gaynor, AM; Nissen MD; et al.. Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathogens (2007) e64, 2007

Le, BM; et al. Clinical and epidemiologic characterization of WU polyomavirus infection, St. Louis, USA. Emerg Infec Dis, 2007

Sang, R; Onyango, C; et al.. Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya. Emerg Infec Dis (2006) 1074, 2006

Urisman, Anatoly; Fischer, Kael F; et al.. “E-predict: a computational strategy for species identification based on observed DNA microarray hybridization patterns”. Genome Biology 6 (2005) R78, 2005

Wang, David; Urisman, Anatoly; et al.. “Viral discovery and sequence recovery using DNA microarrays”. PLOS Biology 1 (2003) 257, 2003

Rota, Paul A.; Oberste, M. Steven; et al.. “Characterization of a novel coronavirus causing severe acute respiratory syndrome”. Science, 300 (2003) 1394, 2003

Wang, David; Coscoy, Laurent; et al.. “Microarray-based detection and genotyping of viral pathogens”. PNAS, 2002

Polson, Andrew; Wang, David; DeRisi, Joseph; Ganem, Don. “Modulation of host cell gene expression by the constitutively active G-protein coupled receptor of Kaposis sarcoma herpes virus (KSHV)”. Cancer Research, 62 (2002) 4525, 2002

Wang, David; Pearlberg, Joseph; Liu, Yu-tsueng; Ganem,Don. “Deleterious effects of hepatitis delta virus replication on host cell proliferation”. Journal of Virology, 75 (2001) 3600, 2001