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Faculty > Faculty By Appointment > Helen Liapis, MD

Professor, Pathology and Immunology
Professor, Medicine (Renal)
Section Head, Nephropathology
3rd Floor, Peters Building
Office: (314) 362-0136
Lab: (314) 747-1069
E-mail: liapis@path.wustl.edu

Research

My focus is on kidney disease including congenital developmental anomalies, medical kidney and allograft pathology, hereditary kidney disease and kidney tumors. My experimental work concentrates on the pathogenesis of congenital obstructive nephropathy in animal models and in humans. We use newborn animals, in vitro systems and gene/protein expression profiling to identify major changes in the developing kidney following congenital obstruction.

Editorial Responsibilities

2009 - PresentEditorial BoardPathology Rsearch International
2003 - PresentEditorial BoardInternational Journal of Urology and Nephrology
2003 - PresentEditorial ReviewNephrology Dialysis Transplantation
2003 - PresentEditorial ReviewAmerican Journal of Kidney Diseases
2003 - PresentEditorial ReviewJournal of the American Society of Nephrology (JASN)
2003 - PresentEditorial ReviewAmerican Journal of Pathology
2003 - 2008Editorial BoardNephron/Experimental Nephrology
2000 - PresentEditorial ReviewKidney International

Service to the Department

2009 - PresentDirector Electron Microscopy
2008 - PresentSection Head Renal Pathology
1995 - PresentRenal &Transplant Pathology

Service to the University

PresentRenal Pathology, portion of Second Year Pathology course
PresentMedical Student Mentor Program for Women
PresentResearch awareness for medical students

Diagnostic Expertise

Renal Pathology
Developmental kidney disease
Solid organ transplantation pathology

Clinical Interest

Anatomic and Molecular Pathology - Renal Pathology
Anatomic and Molecular Pathology - Transplant Pathology

Selected Publications

Sis B, Mengel M, Mark Haas, Robert B. Colvin, Philip F. Halloran, Lorraine C. Racusen, Kim Solez, Liapis H etal.. Banff 09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Group.. Am J Transplant. Mar;10(3):464-71, 2010, 2010 Abstract

Lennerz JK, Spence DC, Iskandar SS, Dehner LP, Liapis H.. Glomerulocystic kidney: one hundred year perspective.. Arch Pathol Lab Med. 134 (4):583-605, 2010, 2010 Abstract

Tripathi P, Guo Q, Wang y, Coussens M, Liapis H, Jain S, Kuehn MR, Capecchi MR, and Chen F.. Axial Structures regulates kidney positioning but not nephrogenesis through Shh.. Dev Bio Apr 15;340(2):518-27,2010, 2010 Abstract

Kedainis RL, Koch MJ, Brennan DC, Liapis H.. Focal C4d + in Renal Allografts is Associated with the Presence of Donor Specific Antibodies and Decreased Allograft Survival.. Am J Transplant. 9(4):812-9, 2009, 2009 Abstract

Liapis H. Molecular Pathology of Nephrotic Syndrome in Childhood. A Contemporary Approach to Diagnosis.. Pediatr Dev Pathol. 11(4):154-63, 2008, 2008 Abstract

Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ. Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Am J Physiol Physiological Genomics. 2007 Jan 17;28(2):193-202. Epub 2006 Sep 19, 2007 Abstract

Solez K, Colvin RB, Racusen LC, Sis B,etal. Banff. Am J Transplant, 2007 Mar;7(3):518-26, 2007 Abstract

Liapis H and Tsokos GC. Pathology and Immunology of lupus nephritis. Can we bridge the two?. Int J Urol Nephrol. 2007;39(1):223-31. Epub 2007 Jan 12, 2007 Abstract

Rogers SA, Chen F, Talcott M, Liapis H, Hammerman MR. Glucose tolerance normalization following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic ZDF rats. Transpl Immunol. 2006 Nov;16(3-4):176-84. Epub 2006 Sep 7, 2006 Abstract

Liapis H, Ho A, Brown D, Mindel G, Gleich G. Thrombotic Microangiopathy associated with idiopathic hypereosinophilia syndrome. Kidney Int 67:1806-1811, 2005 Abstract

Liapis H, Foster K, Theodoropoulou E, Monga G, Mazzucco G. Phenotype/genotype correlations in the Ultrastructure of monogenetic glomerular diseases. Ultrastr Path 28:181-197, 2004 Abstract

Riedlinger WF, Kissane JM, Gibfried M, Liapis H. Congenital bilateral renal arteriovenous malformation (AVM): An unrecognized cause of renal failure in children. Pediatr Dev Pathol 7:285-289, 2004 Abstract

Surendran K, Simon TC, Liapis H, McGuire JK. Matrilysin (MMP-7) expression in renal tubular damage: Association with Wnt4. Kidney Int 65:2212-2222, 2004 Abstract

Cozzolino M, Staniforth ME, Liapis H, Finch J, Burke SK, Dusso AS, Slatopolsky E. Unusual types of diabetic GN and dual disease. Kidney Int 64:1653-1661, 2003 Abstract

Liapis H. Biology of congenital obstructive nephropathy. Nephron Exp Nephrol 93:e87-91, 2003 Abstract

Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis H, Klahr S, Hruska KA. Bone morphogenic protein-7(BMP-7), a novel therapy for diabetic nephropathy. Kidney Int. 63:2037-2049, 2003 Abstract

Rogers SA, Liapis H, Hammerman MR. Intraperitoneal transplantation of pancreatic anlagen. ASAIO J 49:527-532, 2003 Abstract

Schnitzler MA, Lowell JA, Hmiel SP, Hardinger KL, Liapis H, Ceriotti CS, Brennan DC. Cytomegalovirus Disease after Prophylaxis with Oral Ganciclovir in Renal Transplantation: The Importance of HLA-DR Matching. J Am Soc Nephrol 14:780-785, 2003 Abstract

Liapis H, Storch GA, Hill DA, Rueda J, Brennan DC. Invasive CMV infection of the renal allograft is much more common than the pathology indicates: A retrospective analysis of quantitative and qualitative buffy coat CMV-PCR, renal biopsy pathology and tissue CMV-PCR. Nephrol Dial Transpl 18:397-402, 2003 Abstract

Cozzolino M, Staniforth ME, Liapis H, Finch J, Burke SK, Dusso AS, Slatopolsky E. Sevelamer hydrochloride prevents high phosphorus-induced vascular calcifications in long-term experimental uremia. Kidney Int 64:1653-1661, 2003 Abstract

Foster K, Salinas-Madrigal L, Miller B, Liapis H. Unusual types of diabetic GN and dual disease. Semin Diagn Path 19:160-174, 2002 Abstract

Liapis H, Gokden N, Hmiel P, Miner JH. Histopathology, ultrastructure and clinical phenotypes in Thin glomerular basement membrane disease variants. Hum Pathol 33:836-845, 2002 Abstract

Hoch B, Juknevicius I, Liapis H. Glomerular pathology in Hepatitis C; correlation with tissue HC-PCR. Semin Diagn Path 19:175-187, 2002 Abstract

Akimoto T, Liapis H, Hammerman MR. Microvessel formation from mouse embryonic aortic explants is hypoxia and VEGF dependent. Am J Physiol Regul Integr Comp Physiol 283:R487-R495, 2002 Abstract

Liapis H, Barent B, Steinhardt GF. Extracellular matrix in fetal kidney following experimental obstruction. J Urol 166:1433-1438, 2001 Abstract

Guo G, Morrissey J, McCracken, Tolley T, Liapis H, Klahr S. Contributions of angiotensin II and tumor necrosis factor-a to the development of renal fibrosis. Am J Physiol Renal Physiol 280:F777-F785, 2001 Abstract

Liapis H, Yu H, Steinhardt GF. Cell proliferation, apoptosis, Bcl-2 and Bax expression in obstructed opossum early metanephroi. J Urol 164:511-517, 2000 Abstract

Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K, Klahr S, Sampath TK, Morrissey. Osteogenic protein 1 (OP-1) prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 279:F130-F143, 2000 Abstract

Holt DB, Liapis H, Mohanakumar T, Phelan DR, Gandhi SK, Huddleston CB, Canter CE.. Complement fragment C4d and C3d deposition in Pediatric Heart Transplant Recipients with a Positive Crossmatch.. J Heart Lung Transplant, 27(10):1073-8, 2008, Abstract