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Faculty > Faculty By Appointment > Helen Liapis, MDProfessor, Pathology and Immunology
Professor, Medicine (Renal)
3rd Floor, Peters Building
Office: (314) 362-0136
Lab: (314) 747-1069
E-mail: liapis@path.wustl.edu
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Research
| | My focus is on kidney disease including congenital developmental anomalies, medical kidney and allograft pathology, hereditary kidney disease and kidney tumors. My experimental work concentrates on the pathogenesis of congenital obstructive nephropathy in animal models and in humans. We use newborn animals, in vitro systems and gene/protein expression profiling to identify major changes in the developing kidney following congenital obstruction. |
Service to the Department
| | 2009 - Present | Director Electron Microscopy | | 2008 - Present | Section Head Renal Pathology | | 1995 - Present | Renal &Transplant Pathology |
Service to the University
| | Present | Renal Pathology, portion of Second Year Pathology course | | Present | Medical Student Mentor Program for Women | | Present | Research awareness for medical students |
Diagnostic Expertise
| | Renal Pathology | | Developmental kidney disease | | Solid organ transplantation pathology |
Clinical Interest
| | Anatomic and Molecular Pathology - Renal Pathology | | Anatomic and Molecular Pathology - Transplant Pathology |
Selected Publications
| | Sis B, Mengel M, Mark Haas, Robert B. Colvin, Philip F. Halloran, Lorraine C. Racusen, Kim Solez, Liapis H etal.. Banff ’09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Group.. Am J Transplant. Mar;10(3):464-71, 2010, 2010 Abstract
| | Lennerz JK, Spence DC, Iskandar SS, Dehner LP, Liapis H.. Glomerulocystic kidney: one hundred year perspective.. Arch Pathol Lab Med. 134 (4):583-605, 2010, 2010 Abstract
| | Tripathi P, Guo Q, Wang y, Coussens M, Liapis H, Jain S, Kuehn MR, Capecchi MR, and Chen F.. Axial Structures regulates kidney positioning but not nephrogenesis through Shh.. Dev Bio Apr 15;340(2):518-27,2010, 2010 Abstract
| | Kedainis RL, Koch MJ, Brennan DC, Liapis H.. Focal C4d + in Renal Allografts is Associated with the Presence of Donor Specific Antibodies and Decreased Allograft Survival.. Am J Transplant. 9(4):812-9, 2009, 2009 Abstract
| | Liapis H. Molecular Pathology of Nephrotic Syndrome in Childhood. A Contemporary Approach to Diagnosis.. Pediatr Dev Pathol. 11(4):154-63, 2008, 2008 Abstract
| | Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ. Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Am J Physiol Physiological Genomics. 2007 Jan 17;28(2):193-202. Epub 2006 Sep 19, 2007 Abstract
| | Solez K, Colvin RB, Racusen LC, Sis B,etal. Banff. Am J Transplant, 2007 Mar;7(3):518-26, 2007 Abstract
| | Liapis H and Tsokos GC. Pathology and Immunology of lupus nephritis. Can we bridge the two?. Int J Urol Nephrol. 2007;39(1):223-31. Epub 2007 Jan 12, 2007 Abstract
| | Rogers SA, Chen F, Talcott M, Liapis H, Hammerman MR. Glucose tolerance normalization following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic ZDF rats. Transpl Immunol. 2006 Nov;16(3-4):176-84. Epub 2006 Sep 7, 2006 Abstract
| | Liapis H, Ho A, Brown D, Mindel G, Gleich G. Thrombotic Microangiopathy associated with idiopathic hypereosinophilia syndrome. Kidney Int 67:1806-1811, 2005 Abstract
| | Liapis H, Foster K, Theodoropoulou E, Monga G, Mazzucco G. Phenotype/genotype correlations in the Ultrastructure of monogenetic glomerular diseases. Ultrastr Path 28:181-197, 2004 Abstract
| | Riedlinger WF, Kissane JM, Gibfried M, Liapis H. Congenital bilateral renal arteriovenous malformation (AVM): An unrecognized cause of renal failure in children. Pediatr Dev Pathol 7:285-289, 2004 Abstract
| | Surendran K, Simon TC, Liapis H, McGuire JK. Matrilysin (MMP-7) expression in renal tubular damage: Association with Wnt4. Kidney Int 65:2212-2222, 2004 Abstract
| | Cozzolino M, Staniforth ME, Liapis H, Finch J, Burke SK, Dusso AS, Slatopolsky E. Unusual types of diabetic GN and dual disease. Kidney Int 64:1653-1661, 2003 Abstract
| | Liapis H. Biology of congenital obstructive nephropathy. Nephron Exp Nephrol 93:e87-91, 2003 Abstract
| | Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis H, Klahr S, Hruska KA. Bone morphogenic protein-7(BMP-7), a novel therapy for diabetic nephropathy. Kidney Int. 63:2037-2049, 2003 Abstract
| | Rogers SA, Liapis H, Hammerman MR. Intraperitoneal transplantation of pancreatic anlagen. ASAIO J 49:527-532, 2003 Abstract
| | Schnitzler MA, Lowell JA, Hmiel SP, Hardinger KL, Liapis H, Ceriotti CS, Brennan DC. Cytomegalovirus Disease after Prophylaxis with Oral Ganciclovir in Renal Transplantation: The Importance of HLA-DR Matching. J Am Soc Nephrol 14:780-785, 2003 Abstract
| | Liapis H, Storch GA, Hill DA, Rueda J, Brennan DC. Invasive CMV infection of the renal allograft is much more common than the pathology indicates: A retrospective analysis of quantitative and qualitative buffy coat CMV-PCR, renal biopsy pathology and tissue CMV-PCR. Nephrol Dial Transpl 18:397-402, 2003 Abstract
| | Cozzolino M, Staniforth ME, Liapis H, Finch J, Burke SK, Dusso AS, Slatopolsky E. Sevelamer hydrochloride prevents high phosphorus-induced vascular calcifications in long-term experimental uremia. Kidney Int 64:1653-1661, 2003 Abstract
| | Foster K, Salinas-Madrigal L, Miller B, Liapis H. Unusual types of diabetic GN and dual disease. Semin Diagn Path 19:160-174, 2002 Abstract
| | Liapis H, Gokden N, Hmiel P, Miner JH. Histopathology, ultrastructure and clinical phenotypes in Thin glomerular basement membrane disease variants. Hum Pathol 33:836-845, 2002 Abstract
| | Hoch B, Juknevicius I, Liapis H. Glomerular pathology in Hepatitis C; correlation with tissue HC-PCR. Semin Diagn Path 19:175-187, 2002 Abstract
| | Akimoto T, Liapis H, Hammerman MR. Microvessel formation from mouse embryonic aortic explants is hypoxia and VEGF dependent. Am J Physiol Regul Integr Comp Physiol 283:R487-R495, 2002 Abstract
| | Liapis H, Barent B, Steinhardt GF. Extracellular matrix in fetal kidney following experimental obstruction. J Urol 166:1433-1438, 2001 Abstract
| | Guo G, Morrissey J, McCracken, Tolley T, Liapis H, Klahr S. Contributions of angiotensin II and tumor necrosis factor-a to the development of renal fibrosis. Am J Physiol Renal Physiol 280:F777-F785, 2001 Abstract
| | Liapis H, Yu H, Steinhardt GF. Cell proliferation, apoptosis, Bcl-2 and Bax expression in obstructed opossum early metanephroi. J Urol 164:511-517, 2000 Abstract
| | Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K, Klahr S, Sampath TK, Morrissey. Osteogenic protein 1 (OP-1) prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 279:F130-F143, 2000 Abstract
| | Holt DB, Liapis H, Mohanakumar T, Phelan DR, Gandhi SK, Huddleston CB, Canter CE.. Complement fragment C4d and C3d deposition in Pediatric Heart Transplant Recipients with a Positive Crossmatch.. J Heart Lung Transplant, 27(10):1073-8, 2008, Abstract
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