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Research > Faculty By Division > Jack Ladenson, PhD

Oree M. Carroll and Lillian B. Ladenson Professor of Clinical Chemistry, Professor of Pathology and Immunology and Medicine
Co-Medical Director, Clinical Chemistry
West Building, Room 3715
Office: (314) 454-8436
E-mail: ladenson@wustl.edu
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Research

My laboratory is interested in the development of rapid, accurate techniques for the diagnosis and/or prognosis of human disease and the enhancement of basic or clinical research. Our previous work concerned the diagnosis of myocardial infarction (MI). A monoclonal antibody specific to the creatine kinase-MB (CK-MB) isoenzyme was developed which does not react with CK-BB, CK-MM or mitochondrial CK. This antibody is now widely utilized in virtually all commercially available assays for CK-MB. Our work has been extended to the development of the first and still most widely utilized assays for Troponin I and myoglobin. We have also developed a monoclonal antibody to calmodulin, a highly conserved protein throughout animal species and plants which has proved to be a very useful reagent for research investigations. Our current work involves the development of assays to improve the diagnosis of brain injury, both acute and chronic.

For the last fifteen years, I have run the clinical pathology programs for Pathologists Overseas, an organization whose mission is to help improve and provide affordable pathology and clinical laboratory services to under-served patients worldwide. This has lead to a variety of short-term projects, as well as long-term projects in the countries of Eritrea and Bhutan. These efforts, sustained by volunteers, have the goal of upgrading laboratory services, upgrading the training of laboratory personnel, extending laboratory testing to regional hospitals, clinician education, and helping to develop a standardized national laboratory system.

Service to the Department

2003 - 2008Interim Director, Division of Laboratory Medicine

Diagnostic Expertise

Clinical Chemistry
Biomarkers
Laboratory Medicine in developing countries

Clinical Interest

Laboratory and Genomic Medicine - Clinical Chemistry

Selected Publications

Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TLS, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimers Disease. Science Translational Medicine 6(226):226ra30, 2014 Abstract

Gaut JP, Crimmins DL, Ohlendorf MF, Lockwood CM, Griest TA, Brada NA, Hoshi M, Sato B, Hotchkiss RS, Jain S, Ladenson JH. Development of an Immunoassay for the Kidney-Specific Protein myo-Inositol Oxygenase; a Potential Biomarker of Acute Kidney Injury. Clin Chem 60(5):1-11, 2014 Abstract

Tarawneh R, Lee JM, Ladenson JH, Morris JC, Holtzman DM. CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease. Neurology 78:709-19, 2012 Abstract

Rifai N, Diamandis EP, Lo YMD, Kricka LJ, Wilding P, Ladenson JH, Wittwer CT. Advancing Laboratory Medicine through Innovation: A Tale of Six Inventors. Clin Chem 58:502-10, 2012 Abstract

Tarawneh R, D. Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease. Ann Neurol 70:274-85, 2011 Abstract

Ladenson, JH. Troponin I, The Story. Clin Chem 56:482-483, 2010 Abstract

Lee JM, Blennow K, Andreasen N, Laterza O, Modur V, Olander J, Gao F, Ohlendorf M, Ladenson JH. The brain injury VLP-1 is increased in the cerebrospinal fluid of Alzheimer. Clin Chem 54:1617-1623, 2008 Abstract

Ladenson JH. A personal history of markers of myocyte injury [myocardial infarction]. Clinica Chimica Acta 381(1):3-8, 2007 Abstract

Scott MG, Morin S, Hock KG, Seyoum M, Ladenson JH. Establishing a simple and sustainable quality assurance program and clinical chemistry services in Eritrea. Clin Chem 53(11):1945-1953, 2007 Abstract

Windus DW, Ladenson JH, Merrins CK, Seyoum M, Windus D, Morin S, et al. Impact of a multidisciplinary intervention for diabetes in Eritrea. Clin Chem 53(11):1954-1959, 2007 Abstract

Laterza OF, Modur VR, Crimmins DL, Olander JV, Landt Y, Lee JM, Ladenson JH. Identification of novel brain biomarkers. Clin Chem: 52:1713-1721, 2006 Abstract

Ladenson RC, Crimmins DL, Landt Y, Ladenson JH. Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment. Anal Chem 78:4501-4508, 2006 Abstract

Rosalki SB, Roberts R, Katus HA, Giannitsis E, Ladenson JH. Cardiac biomarkers for detection of myocardial infarction: Perspectives from past to present. Clin Chem 50:2205-2213, 2004 Abstract

Ladenson JH, Scott MG, Klarkowski D, Seyoum M. The Use of a Major Medical Center Clinical Laboratory as a Reference Laboratory for a Developing Country. Clin Chem 49:162-166, 2003 Abstract

Adams III, JE, Bodor GS, Dāvila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. Cardiac troponin-I: a marker with high specificity for cardiac injury. Circulation 88:101-10, 1993 Abstract

Bodor GS, Porter S, Landt Y, Ladenson JH. Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction. Clin Chem 38:2203-2214, 1992 Abstract

Silva DP, Landt Y, Porter SE, Ladenson JH. Development and application of monoclonal antibodies to human cardiac myoglobin in a rapid fluorescence immunoassay. Clin Chem 37:1356-1364, 1991 Abstract

Vaidya HC, Maynard Y, Ladenson JH. Direct measurement of creatine kinase-MB activity in serum after extraction with a monoclonal antibody specific to the MB isoenzyme. Clin Chem 32:657-663, 1986 Abstract