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Training > Residency Program > Faculty Alphabetical > Friederike Kreisel, MD

Associate Professor, Pathology and Immunology
Kingshighway Building, 2rd Floor, Room 2463
Office: (314) 362-0346
E-mail: fkreisel@wustl.edu
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Research

Over the past few years I have directed my research focus towards immunophenotyping and genetic profiling of B-cell lymphomas. Several of my projects relate to morphologic and immunophenotypic characterization of immunodeficiency-associated B-cell lymphoproliferative disorders as well as genetic alterations in diffuse large B-cell lymphoma that predict response to immuno-chemotherapy.

Editorial Responsibilities

2007 - PresentReviewerAmerican Journal of Hematology
2004 - PresentReviewerArchives of Pathology and Laboratory Medicine

Service to the Department

2009 - PresentHematopathology Educational Committee, Department of Pathology and Immunology
2007 - PresentMedical Director, Clinical Flow Cytometry, Barnes-Jewish Hospital
2007 - 2008Member, Resident Selection Committee, Department of Pathology and Immunology
2003 - PresentAttending Physician, Hematopathology, Barnes-Jewish Hospital

Service to the University

2010 - PresentMember, University Scholars Program Medical School Committee, Washington University
2008 - PresentSection Leader, Hematopathology, 2nd Year Medical School Pathology Course
2008 - PresentMember, Committee on Admissions, Washington University Medical School
2005 - 2007Lecturer, 2nd Year Medical School Pathology Course, Hematopathology

Diagnostic Expertise

Hematopathology

Clinical Interest

Anatomic and Molecular Pathology - Hematopathology

Selected Publications

F. Kreisel, S. Kulkarni, R. T. Kerns, A. Hassan, H. Deshmukh, R. Nagarajan, J. L. Frater, A. Cashen. High-resolution array comparative genomic hybridization (aCGH) identifies copy number alterations in diffuse large B-cell lymphoma that predict response to immuno-chemotherapy. Cancer Genet. 204(3):129-137, 2011 Abstract

C. Amador-Ortiz, L. Chen, A. Hassan, J.L. Frater, R. Burack, T.T. Nguyen, F. Kreisel. Combined core needle biopsy and fine needle aspiration with ancillary Studies correlate highly with traditional techniques in the diagnosis of nodal-based lymphoma. Am J Clin Pathol. 135(4):516-24, 2011 Abstract

J.M. Klco, S. Kulkarni, F.H. Kreisel, T.T. Nguyen, A. Hassan, J.L. Frater. Immunohistochemical analysis of monocytic leukemias: utility of CD14 and Krüppel-like factor 4, a novel monocytic marker. Am J Clin Pathol. 135(5):720-30, 2011 Abstract

F. Kreisel. Phenytoin-induced pseudolymphoma manifesting as gamma/delta T-cell lymphocytosis. Case Report. Accepted in Cytometry Part B, 2011

T. Ammar, F. Kreisel, M. A. Ciorba. Primary antral duodenal extramedullary plasmacytoma presenting with melena. Clin Gastroenterol Hepatol. 8(1):A32, 2010 Abstract

S. Krishmurthy, A. Hassan, J. L. Frater. M. E. Paessler, F. Kreisel. Pathologic and clinical features of Hodgkin lymphoma-like post transplant lymphoproliferative disease. Int J Surg Pathol. 18(4):278-85, 2010 Abstract

J. M. Klco, B Geng, E. M. Brunt, A. Hassan, T. D. Nguyen, F. H. Kreisel, M. Lisker-Melman, J. L. Frater. Bone marrow biopsy in patients with hepatitis C virus infection: Spectrum of findings and diagnostic utility. Am J Hematol. 85(2):106-10, 2010 Abstract

F.H. Kreisel, J. Frater, A. Hassan, S.K. El-Mofty. Cystic lymphoid hyperplasia of the parotid gland in HIV-positive and HIV-negative patients: quantitative immunopathology. OOOOE. 109(4):567-74, 2010 Abstract

A.E. Gelman, M. Okazaki, S. Sugimoto, W. Li, C.G. Kornfeld, J. Lai, S.B. Richardson, F.H. Kreisel, H.J. Huang, J.R. Tietjens, B.H. Zinselmeyer, G. A. Patterson, M.J. Miller, A.S. Krupnick, D. Kreisel. CCR2 regulates monocyte recruitment as well as CD4+ Th1 allorecognition after lung transplantation. Am J Transplant. 10(5):1189-99, 2010 Abstract

J.M. Klco, R Vij, F.H. Kreisel, A. Hassan, J.L. Frater. Molecular pathology of myeloproliferative neoplasms. Am J Clin Pathol 133(4):602-15, 2010 Abstract

M. Okazaki, S. Sugimoto, J. Lai, C. G. Kornfeld, R. S. Hotchkiss, S.B. Richardson, W. Li, F. H. Kreisel, H. J. Huang, G. A. Patterson, A. S. Krupnick, A. E. Gelman, D. Kreisel. Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of bcl-2 in the recipient. Transplant Proc. 41(1):385-7, 2009 Abstract

M. Martin, R. Walgren, E. Procknow, G. Uy, K. Stockerl-Goldstein, A. Cashen, P. Westervelt, C. Abboud, F. Kreisel, K. Augustin, J. DiPersio, R. Vij. A phase II study of 5-day intravenous azacitidine in patients with myelodysplastic syndromes. Am J Hematol. 84(9):560-4, 2009 Abstract

A. E. Gelman, W. Li, S. B. Richardson, B. H. Zinselmeyer, J. Lai, M. Okazaki, C. G. Kornfeld, F. H. Kreisel, S. Sugimoto, J. R. Tietjens, J. Dempster, G. A. Patterson, A. S. Krupnick, M. J. Miller, D. Kreisel. Cutting edge. Acute lung allograft rejection is independent of secondary lymphoid organs. J Immunol. 182(7):3969-73, 2009 Abstract

V. L. Tarakanova*, F. Kreisel*, D. W. White, H. W. Virgin 4th * shared first authorship. Murine gammaherpesvirus-68 genes both induce and suppress lymphoproliferative disease. J. Virol. 82(2):1034-9, 2008 Abstract

A. E. Gelman, M. Okazaki, J. Lai, C. G. Kornfeld, F. H. Kreisel, S. B. Richardson, S. Sugimoto, J. R. Tietjens, G. A. Patterson, A. S. Krupnick, D. Kreisel. CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants. J. Immunol. 180(7):4754-62, 2008 Abstract

J. Lu, J. L. Frater, F. H. Kreisel, J. N. Marcus, A. Hassan. Secondary lymphoma involvement of metastatic follicular thyroid carcinoma to the skull: a unique example of tumor-to-tumor metastasis. Head and Neck Pathol. 2(3):209-12, 2008 Abstract

R. K. Funk, T. J. Maxwell, M. Izumi, D. Edwin, F. Kreisel, T. J. Ley, J. M. Cheverud, T. A. Graubert. Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice. Blood. 112(4):1434-42, 2008 Abstract

J. M. Klco, F. H. Kreisel, B. A. Zehnbauer, S. Kulkarni, A. Hassan, J. L. Frater. The spectrum of adult B-lymphoid leukemias with BCR-ABL: molecular diagnostic, cytogenetic, and clinical laboratory perspectives. Am J Hematol. 83(12):901-7, 2008 Abstract

Z. Xiang, F. Kreisel, J. Cain, A. L. Colson, M. H. Tomasson. Neoplasia driven by mutant c-kit is mediated by intracellular, not plasma membrane, receptor signaling. Mol. Cell. Biol. 27(1):267-82, 2007 Abstract

M. Okazaki, F. Kreisel, S. B. Richardson, D. Kreisel, A. S. Krupnick, A. Patterson, A. E. Gelman. Sphingosine 1-phosphate inhibits ischemia re-perfusion injury following experimental lung transplantation. Am. J. Transplant. 7(4):751-8, 2007 Abstract

J. A. Cain, Z. Xiang, J. O’Neal, F. Kreisel, A. Colson, L. Henninghausen, M. H. Tomasson. Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage. Blood. 109(9):3906-14, 2007 Abstract

F. Kreisel. Doughnut ring-shaped epithelioid granulomas in the bone marrow of a patient with Q fever. Int. J. Surg. Pathol. 15(2):172-3, 2007 Abstract

A. Hassan, F. Kreisel, L. Gardner, J. Lewis, S. K. El-Mofty. Plasmablastic lymphoma of head and neck: Report of two new cases and correlation with c-myc and IgVH gene mutation status. Head and Neck Pathol. 1:150-55, 2007 Abstract

R. Jarett, N. Walk, A. Castellano-Sanchez, F. H. C. Kreisel. Pathology quiz case: A 68-year-old male with shortness of breath and peripheral edema. Arch Pathol Lab Med. 130(2):219-22, 2006 Abstract

F. H. Kreisel, A. Blasius, D. Kreisel, M. Colonna, M. Cella. Interferon-producing cells develop from murine CD31high/Ly6C− marrow progenitors. Cell. Immunol. 242(2):91-8, 2006 Abstract

A. S. Krupnick, A. E. Gelman, W. Barchet, S. Richardson, F. H. Kreisel, L. A. Turka, M. Colonna, G. A. Patterson, D. Kreisel. Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells. J Immunol. 175(10):6265-70, 2005 Abstract

D. Kreisel, M. K. Pasque, R. J. Damiano Jr., G. Medoff, A. Kates, F. H. Kreisel, J. S. Lawton. Bartonella species-induced prosthetic valve endocarditis associated with rapid progression of valvular stenosis. J Thorac Cardiovasc Surg. Thorac. Cardiovasc. Surg. 130(2):567-8, 2005 Abstract

H. Luo, Q. Li, J. O’Neal, F. Kreisel, M. M. Le Beau, M. H. Tomasson. C-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated anti-apoptotic mutations. Blood. 106(7):2452-61, 2005 Abstract

A. Castellano-Sanchez and F. H. C. Kreisel. Pathology quiz case: a 39-year-old man with severe lower back pain. Plasma cell leukemia. Arch. Pathol. Lab. Med. 129(3):e70-2, 2005 Abstract

S. Krupnick, J.V. Lombardi, F. H. Engels, D. Kreisel, H. Zhuang, A. Alavi, J.P. Carpeneter. 18-Fluorodeoxyglucose Positron Emission Tomography as a novel imaging tool for the diagnosis of aortoenteric fistula and aortic graft infection. Vasc. Endovascular Surg. 37 (5): 363-366, 2003 Abstract

D. Kreisel, A. S. Krupnick, A. E. Gelman, F. H. Engels, S. H. Popma, A. M. Krasinskas, K. R. Balsara. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of allorecognition. Nature Medicine 8: 233-239, 2002 Abstract

M. Paessler, F. H. Kreisel, V. A. LiVolsi, L. A. Akslen, Z. W. Baloch. "Can we rely on pathologic parameters to define conservative treatment of papillary thyroid carcinoma.". Internat. J. Surg. Path. 10: 267-272, 2002 Abstract

M. B. Faries, I. Bedrosian, S. Xu, J. Roros, M. A. Moise, H. Q. Nguyen, F. Engels, B. J. Czerniecki. Calcium signaling inhibits IL-12 production and activates CD83+ dendritic cells that induce Th2 cell development. Blood 98: 2489-2497, 2001 Abstract

F. Engels, D. Kreisel, I. Bedrosian, G. Koski, M. Faries, P Cohen, B. Czerniecki. Calcium ionophore activation of CML progenitor cells into antigen-presenting cells is mediated through activation of calcineurin phosphatase. Leuk. Res. 24:795-804, 2000 Abstract

Bedrosian, J. G. Roros, S. Xu, H. Q. Nquyen, F. Engels, M. B. Faries, G. K. Koski, P. A. Cohen, B. Czerniecki. GM-CSF, IL-2 and IL-12 synergize with calcium ionophore to enhance dendritic cell function. J. Immunother. 23:311-32, 2000 Abstract

F. Engels, D. Kreisel, I. Bedrosian, G. Koski, M. Faries, P Cohen, B. Czerniecki. Calcium signaling induces acquisition of dendritic cell characteristics in chronic myelogenous leukemia myeloid progenitors. Proc. Natl. Acad. Sci. USA 96: 10332-10337, 1999 Abstract

G. Koski, G. Schwartz, D. Weng, R. Gress, F. Engels, M. Toskos, B. J. Czerniecki, P. A. Cohen. Calcium ionophore-treated myeloid cells acquire many dendritic cell characteristics independent of prior differentiation state, transformation status or sensitivity to biologic agents. Blood 94: 1359-1371, 1999 Abstract