Research > Faculty By Clinical Interest > Anjum Hassan, MD

Associate Professor, Pathology and Immunology
Institute of Health at BJH 3rd floor office # 3436
Office: (314) 747-1120
Publication List


My past research involved work on small lymphocytic leukemia, a project that eventually involved setting up the system for direct sequencing of immunoglobulin genes from paraffin sections. Another focus of my previous research involved studying the pathogenesis of Multiple Myeloma, a pilot study to optimize PCR detection of ras mutations in archival material in the Department of Pathology and Immunology and correlating that with t(4;14) and t(11;14) in established myeloma cases. For additional information on my papers, please refer to my portfolio. My current research focuses mainly of translational projects with a focus on B- cell Non-Hodgkin lymphoma and research related to reviews and updates of previously authored book chapters.

Service to the University

2014 - PresentCoarse Director, WUSM hematopathology electives
2010 - PresentMedical Director FFPE FISH in Cytogenomics and Molecular Pathology
2008 - PresentMember, Committee on Admissions, Washigton Univ. School of Medicine
2006 - 2009Assistant Director, Fluorescent in-situ Hybridization Lab in Anatomic Pathology
2005 - 2008Second year Adrenal pathology course
2005 - PresentSecond year medical student Hematopathology Lab curriculum

Diagnostic Expertise

Board certified in Anatomic and Clinical Pathology ; Board certified in Hematopathology
Histopathology and related ancillary studies of hematopoietic malignancies; Florescent -in-situ- hybridization testing of hematopoietic and non-hematopoietic tumors in formalin fixed, parraffin embedded tissue

Clinical Interest

Anatomic and Molecular Pathology - Hematopathology

Selected Publications

Xiao J , Nguyen T, Frater J.L, Kreisel F, Hassan A.. Evolution of Mantle Cell Lymphoma “in situ” Contributing to Immune Thrombocytopenia.. Leukemia and lymphoma., 2014

Klein J.L, Nguyen T.T., Bien-Willner G, Chen L, Foyil K.V,Bartlett N, Duncavage E.J, Hassan A, Frater J.L, Kreisel F. CD163 is a more useful immunohistochemical stain than CD68 in predicting outcome of patients with classical Hodgkin lymphoma.. Am J Clin Pathol, 2014

Gru AA, Kreisel F, Duncavage E, Nguyen TT, Hassan A, Frater J. Acute EBV infection masquerading as "in-situ follicular lymphoma": A pitfall in the differential diagnosis of this entity. Diagn Pathol, 2013

Xiandong X, Hassan A. Hairy cell leukemia misdiagnosed as Large cell lymphoma: Immunohistochemical studies aiding differential diagnosis.. J applied hematol, 2013

Hussaini MO, Klein J, Xiao J, Frater J.L, Kreisel F, Hassan A.. Richter Syndrome: an Unusual Report of Concurrent Small Lymphocytic Lymphoma, Hodgkin Lymphoma, and Anaplastic Plasmacytoma.. J applied hematol, 2013

Xiandong X, Hassan A. Extranodal marginal zone lymphoma arising in a patient with chronic myelogenous leukemia on long term decitabine therapy. Leukemia and lymphoma, 2013

Gru A.A, Hussaini M, Nguyen T, Frater J.L, Kreisel F, Hassan A. High prevalence of 1p36 microdeletions in B-cell non-Hodgkin lymphomas associated with PAX7 loss. Int J Lab Hematol, 2013

Pittman M, Treese S, Chen L, Frater J.L, Nguyen TT, Hassan A. Utility of flow cytometry of cerebrospinal fluid as a screening tool in the diagnosis of central nervous system lymphoma. Arch Pathol Lab Med, 2012

Wang T, Klein JL, Woodard PK, Hassan A, Joseph SM, Ewald GA, Uy GL. Plasmacytoma-like Posttransplant Lymphoproliferative Disease Occurring in a Cardiac Allograft: A Case Report and Review of Literature.. J Clin Oncol, 2012

Deetz C.O, Scott M.G., Ladenson J.H., Seyoum M., Hassan A, Kreisel F.H, Nguyen T.T, Frater J.L. Use of a United States-based laboratory as a hematopathology reference center for a developing country: logistics and results. Int J Lab Hematol, 2012

Warrick J, Luo J, Robirds D, Branson J, Frater J.L, Kreisel F, Hassan A, Nguyen T.T. Gastrointestinal lymphomas in a North American population: clinicopathologic features from one major Central-Midwestern United states tertiary care medical center. Diagn Pathol, 2012

Yeung C.C, Mills JC, Hassan A, Kreisel F.H, Nguyen T.T, Frater J.L. A novel marker of plasmacytic differentiation. Appl Immunohistochem Mol Morphol, 2012

Hussaini M, Kreisel F , Hassan A. Impact of proliferative indices and tumor suppressor genes on treatment response in marginal zone lymphomas. comp clin pathol, 2012

Welch J S, Klco J M, Gao F, Cashen A. F, Uy G. L, Stockerl-Goldstein K. E, Abboud C.M , Westervelt P, DiPersio J.F , Hassan A, Vij R. . Combination Decitabine, Arsenic trioxide and Ascorbic Acid for the Treatment of Myelodysplastic syndrome and Acute Myeloid Leukemia:a phase I study. Am J Hematol, 2011

Amador-Ortiz C, Hurley M.Y, Ghahramani G.K, Frisch S, Klco J.M, Lind A.C, Nguyen T.T, Hassan A, Kreisel F.H, Frater J.L. Use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma. J Cutan Path, 2011

Klco J.M, Welch J.S, Nguyen T.T, Hurley M.Y, Kreisel F, Hassan A, Lind A.C, Frater J.L. State of art in myeloid sarcoma. Int J Lab Hematol, 2011

Kreisel F, Kulkarni S, Kerns R. T, Hassan A , Deshmukh H, Nagarajan R , Frater J. L, Cashen A. High-resolution array comparative genomic hybridization (aCGH) identifies copy number alterations in diffuse large B-cell lymphoma that predict response to immuno-chemotherapy. Cancer Genet, 2011

Amador-Ortiz C, L. Chen, A. Hassan, J.L. Frater, R. Burack, T.T. Nguyen, F. Kreisel. Combined core needle biopsy and fine needle aspiration with ancillary Studies correlate highly with traditional techniques in the diagnosis of nodal-based lymphoma. Am J Clin Pathol., 2011

Klco J.M,Kulkarni S, Kreisel F.H, Nguyen T.T, Hassan A, Frater J.L. Immunohistochemical analysis of monocytic leukemias: utility of CD14 and Krüppel-like factor 4, a novel monocytic marker. Am J Clin Pathol, 2011

Nanua S, Bartlett N, Hassan A, Robirds D, Brawson J, Frater J. L, Nguyen T.T, Kreisel. Composite diffuse large B-cell lymphoma and precursor B lymphoblastic lymphoma presenting as a double-hit lymphoma with MYC and BCL2 translocation.. J clin pathol, 2011

Yeung C CS, Powers MLE, Kreisel F.H, Frater J. L, Zehnbauer B. A, Burack R, Hassan A. Relevance of Somatic Hypermutation and Interphase Cytogenetics in Lymphomatous Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL). Int J Surg Pathol, 2011

Hassan A. Minimal residual disease testing in acute leukemia. J app hematol, 2011

Ansstas G, Mosley J.C, Bryant G, Hassan A, Amador-Ortiz C, Procknow E, Vij R. Efficacy and Tolerability of PTK787/ZK 222584 in a Phase II Study of Post-Transplant Maintenance Therapy in Patients with Multiple Myeloma Following High-Dose Chemotherapy and Autologous Stem Cell Transplant. Leukemia and Lymphoma, 2010

Klco J.M, Vij R, Kreisel F.H, Hassan A, Frater J.L. Molecular pathology of myeloproliferative neoplasms. Am J Clin Pathol, 2010

Kreisel F.H, Frater J, Hassan A, El-Mofty S.K. Cystic lymphoid hyperplasia of the parotid gland in HIV-positive and HIV-negative patients. Quantitative Immunopathology, 2010

Cai S F., Cao X, Hassan A, Fehniger TA., and Ley TJ. Granzyme B is not required for regulatory T cell mediated suppression of graft-versus-host Disease. Blood, 2010

Klco J. M, Geng B, Brunt E. M, Hassan A, Nguyen T. D, Kreisel F. H, Lisker-Melman M, Frater J. L. Bone marrow biopsy in patients with hepatitis C virus infection: Spectrum of findings and diagnostic utility. Am J Hematol, 2010

Krishmurthy S, Hassan A, Frater J. L, Paessler M. E, Kreisel F. Pathologic and clinical features of Hodgkin lymphoma-like post transplant lymphoproliferative disease. Int J Surg Pathol, 2010

O'Neal J, Molitoris A, Gao F, Hassan A , Monahan R, Barrios S, Weilbaecher K, Vij R, Tomasson M. Neurobeachin (NBEA) is a target of recurrent interstitial deletions at 13q13 in patients with MGUS and multiple myeloma. Experimental Hematology, 2009

Klco JM, Kreisel FH, Zehnbauer BA, Kulkarni S, Hassan A, Frater JL. The spectrum of adult B-lymphoid leukemias with BCR-ABL: molecular diagnostic, cytogenetic, and clinical laboratory perspectives.. Am J Hematol, 2008

Powers M LE, Watson BW, Frater JL, Kreisel F, Hassan A. Peripheral Eosinophilia Camouflaging Anaplastic Large Cell Lymphoma. Int J. Surg. Pathol, 2008

Zhao, XF, Hassan A, Perry A, Ning Y, Stass SA, Dehner LP. B-cell lymphomas with atypical morphology and c-myc rearrangements. Int J clin exp pathol 1(1): 65-74,2008 ., 2008

Hassan A, Kreisel F, Lewis J, Gardner L, El-Mofty S.. Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status. Head and Neck pathology, Oct 2007, available on line. DOI 10.1007/s12105-007-00060-5., 2007

Kaleem Z, Hassan A.. Pathologic Quiz Case: Multiple lytic bone lesions in an 85-year-old man.. Arch Pathol Lab Med 129:e148-150, 2005 Abstract

Hassan A, Yerian LM, Kuan SF, Xiao SY, Hart J, Wang HL. Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin D1, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polyps.. Hum Pathol 35:328-334, 2004 Abstract

Kaleem Z, Hassan A, Pathan MH, White G.. Flow Cytometric Evaluation of Posttransplant B-Cell Lymphoproliferative Disorders.. Arch Pathol Lab Med 128:181-186, 2004 Abstract

Hassan A, Bennet A, Bhalla S, Ylagan LR, Mutch D, Dehner LP. Paraganglioma of the vagina: Ultrastructural and immunohistochemical study.. Int J Gynecol Pathol, 22:404-406, 2003 Abstract

Liapis H, Hassan A. Idiopathic light chain deposition disease without clinical evidence of Multiple Myeloma. Int Urol Nephrol 35:579-580, 595-596, 2003 Abstract

Coopersmith CA, Lowell JA, Hassan A, Howard TK. Hepatocellular carcinoma in a patient with focal nodular hyperplasia.. Arch Pathol Lab Med 128:181-186, 2002

Current Trainees

Anmaar Abdul-Nabi
Barina Aqil
Angela Foster, MD
Yi-Shan Lee
Jennifer Obrien, MD, PhD
Shuaib Okponobi
Naresh Pemmaraju
Xiaodong Zhou

Past Trainees

Assistant Professors
Syed Zaidi, MD

In Trainings
Catalina Amador-Ortiz, MD
Mohammad Hussaini, MD
Yuanming Zhang, MD