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Research > Faculty By Division > Ann Gronowski, PhD

Professor, Pathology and Immunology
Co-Medical Director, Clinical Chemistry
Professor, Obstetrics and Gyncology
BJH Service Building, 2nd Floor, Room 276
Office: (314) 362-0194
E-mail: gronowski@pathology.wustl.edu
Publication List

Research

My lab focuses primarily on the laboratory diagnostics of endocrinology and reproductive physiology with a particular emphasis on maternal fetal medicine. Recently, our work has examined how to properly assess the risk for fetal lung maturity using either lamellar body counts or a method using fluorescent polarization. We have developed easy-to-use tables for the assessment of risk for respiratory distress syndrome using results from the fluorescent polarization assay and gestational age.

We have also examined the cytokines IL-6, TNFá, and IL-2 receptor in cervicovaginal fluid as markers of impending preterm delivery. Cytokines have been shown to be associated with preterm delivery in serum and amniotic fluid, but few studies have been done using cervicovaginal fluid. Our studies suggest that IL-6 performs similar to fetal fibronectin in predicting delivery within 14 days.

Our work has also investigated the hormone hCG (human chorionic gonadotropin) and how its concentrations increase with age. Although hCG is best know for its production by the placenta, similar to the other members of the glycoprotein hormone family, hCG is also produced in the pituitary gland. We and others have shown that like serum concentrations of LH and FSH, serum hCG increases during the peri- and post-menopausal periods. Our research has focuses on ways to differentiate between pituitary and placental hCG.

Editorial Responsibilities

2007 - PresentEditorial BoardClinical Chemistry
2000 - 2006Editorial BoardClinica Chimica Acta

Diagnostic Expertise

Endocrinology and reproductive physiology, maternal fetal medicine, serology

Clinical Interest

Laboratory and Genomic Medicine - Immunology
Laboratory and Genomic Medicine - Clinical Chemistry
Laboratory and Genomic Medicine - Serology

Published Books

Handbook of Clinical Laboratory Testing During Pregnancy. Ed, Gronowski AM. Humana Press, Totowa, NJ. 2004.
Tietz Applied Laboratory Medicine, 2nd Edition. Eds., Scott MG, Gronowski AM, Eby CS. John Wiley & Sons, Inc., Hoboken, NJ. 2007.

Selected Publications

Halldorsdottir AM, Grenache DG, Snyder J, Chowning RT, Gronowski AM. Comparison of various methods for amniotic fluid delta 450 bilirubin measurement. Clin Chim Acta 389:160-163, 2008 Abstract

McClellan A, Gronowski AM. Experience using rules-based physiological profiling to detect laboratory errors. Letter to Editor. Clin Chim Acta 390:159-160, 2008 Abstract

Gronowski AM, Fantz CR, Parvin CA, Sokoll LJ, Wiley C, Wener MH, Grenache DG. Use of serum FSH to identify peri-menopausal women with pituitary hCG. Clin Chem 54:652-656, 2008 Abstract

Woodworth A, Moore J, G’Sell C, Verdoes A, Snyder JA, Morris L, Wares C, Grenache DG, Gronowski AM. Diagnostic accuracy of cervicovaginal interleukin-6 and interleukin-6:albumin ratio as markers of preterm delivery. Clin Chem 53:1534-1540, 2007 Abstract

Haymond S, Luzzi VI, Parvin CA, Gronowski AM. A direct comparison between Lamellar body counts and the fluorescent polarization methods for predicting respiratory distress syndrome. Am J Clin Path 126:894-899, 2006 Abstract

Bildirici I, Moga CV, Gronowski AM, Sadovsky Y. The weekly increment of amniotic fluid TDx-FLM II ratio is constant during the latter part of pregnancy. Am J Obstet Gyn 193:1685-1690, 2005 Abstract

Parvin CA, Kaplan LA, Chapman JF, McManamon TG, Gronowski AM.. Predicting respiratory distress syndrome using gestational age and fetal lung maturity by fluorescent polarization.. Am J Obstet Gyn 192:199-207, 2005 Abstract

Snyder JA, Haymond S, Parvin CA, Gronowski AM, Grenache DG.. Human chorionic gonadotropin increases with age in non-pregnant women.. Clin Chem 51: 1830-1835, 2005 Abstract