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Faculty > Faculty By Appointment > Marco Colonna, MD

Professor, Pathology and Immunology
Professor, Medicine
Robert Rock Belliveau, M.D., Professorship in Pathology
Office Suite B - 8210, BJCIH Building
Office: (314) 747-1221
Lab: (314) 362-0368
E-mail: mcolonna@wustl.edu
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Postdoctoral Training Program in Diabetes Research

Research

My laboratory studies human and murine innate responses against pathogens. Cells involved in innate responses use different types of receptors to recognize pathogens and tumors. Pattern recognition receptors recognize molecular structures shared by disparate microorganisms. Activating receptors recognize "alert molecules" that are only expressed when cells are infected or transformed. Inhibitory receptors recognize MHC class I molecules or other molecules constitutively expressed in normal cells. When infection and neoplastic transformation cause reduction of MHC class I, inhibitory receptors are no longer engaged, releasing innate responses from inhibition.

We have discovered the KIR and ILT receptors that allow natural killer cells, monocytes, macrophages and dendritic cells (DC) to detect infected cells with reduced levels of MHC class I molecules. More recently we have characterized the TREM receptors that trigger inflammatory responses of granulocytes and monocytes and activate DC. We are presently investigating the ligands of TREM receptors as well as their function in vivo.

We have also found that DC differ in the type of ILT receptors expressed on the cell surface. This observation has led to the identification of a subset of DC called plasmacytoid DC or natural interferon-producing cells (IPC). IPC are specialized in the production of interferon-á, â and ù, providing a first line of defense against viral replication and promoting Th1 polarization of T helper cells. We are currently studying the role of IPC in viral infections using in vivo models.

Selected Publications

Bouchon A, Hernandez-Munain C, Cella M, Colonna M.. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.. J Exp Med 194:1111-1122, 2001 Abstract

Bouchon A, Facchetti F, Weigand MA, Colonna M.. TREM-1 amplifies inflammation and is a crucial mediator of septic shock.. Nature 410:1103-1107, 2001 Abstract

Cella M, Facchetti F, Lanzavecchia A, Colonna M.. Blood plasmacytoid dendritic cells mature upon stimulation with influenza virus and CD40L and drive a potent Th1 polarization.. Nat Immunol 1:305-310, 2000 Abstract

Dietrich J, Cella M, Seiffert M, Buhring HJ, Colonna M.. Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.. J Immunol 164:9-12, 2000 Abstract

Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A, Colonna M.. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon.. Nat Med 5:919-923, 1999 Abstract

Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M.. A Common Inhibitory Receptor for MHC Class I Molecules on Human Lymphoid and Myelomonocytic Cells.. J Exp Med 186:1809-1818, 1997 Abstract

Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M.. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.. J Exp Med 185:1743-1751, 1997 Abstract

Colonna M, Samaridis J.. Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human NK Cells.. Science 268:405-408, 1995 Abstract

Colonna M, Spies T, Strominger JL, Ciccone E, Moretta A, Moretta L, Pende D, Viale O.. Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.. Proc Natl Acad Sci USA 89:7983-7985, 1992 Abstract


Current Trainees

Maristela Hernandez
Leonid Gitlin
Ilaria Tassi
Izumi Kawachi

Past Trainees

Winfried Barchet
Kent Boles
Graduate Students
Isaiah Turnbull
Timothy Wilson

Postdoctoral Fellows
Amanda Blasius
Gaelle Le Friec