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Research > Faculty By Clinical Interest > Peter A. Humphrey, MD, PhD

Ladenson Professor, Pathology and Immunology
Professor of Urologic Surgery
Head, Division of Anatomic and Molecular Pathology
Surgical Pathologist-in-Chief, Barnes-Jewish Hospital
3rd Floor, Peters Building
Office: (314) 362-0112
E-mail: humphrey@wustl.edu
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Research

The primary focus of my research is on urologic malignancies in general and specifically on prostate adenocarcinoma. At the clinicopathologic level, investigations on the surgical pathology of the prostate gland are performed including morphometric analysis of prostate cancer, studies on prostatic intraepithelial neoplasia, a putative precancerous proliferation, and histomorphologic studies on prostate cancer and its variants. Gene discovery and marker discovery in potential prostate cancer precursors and prostatic carcinoma are being pursued via gene expression profiling and whole genome sequencing.

Editorial Responsibilities

2009 - 2011Member, Editorial BoardHuman Pathology
2009 - 2011Member, Editorial BoardAnnals of Diagnostic Pathology
PresentAssociate EditorAmerican Journal of Clinical Pathology
PresentMember, Editorial BoardThe American Journal of Surgical Pathology
PresentMember, Editorial BoardModern Pathology

Service to the Department

PresentChief of Anatomic & Molecular Pathology
PresentMember, Resident Selection Committee

Service to the University

PresentMedical Student (2nd Year) Lectures on prostate cancer, bladder diseases, testis diseases

Diagnostic Expertise

Urological pathology, especially urological malignancies, including prostate cancer, bladder cancer, kidney cancer, and testis cancer

Clinical Interest

Anatomic and Molecular Pathology - Molecular Pathology
Anatomic and Molecular Pathology - Urologic Pathology

Selected Publications

Hameed O, Humphrey PA.. Pseudoneoplastic mimics of prostate and bladder carcinomas.. Arch Pathol Lab Med 2010; 134:427-443., 2010 Abstract

Cao D, Kibel AS, Gao F, Tao Y, Humphrey PA.. The Gleason score of tumor at the margin in radical prostatectomy is predictive of biochemical recurrence.. Am J Surg Pathol 2010; 34:459-463., 2010 Abstract

Yaskiv O, Cao D, Humphrey PA.. Microcystic adenocarcinoma of the prostate. A variant of pseudohyperplastic and atrophic patterns.. Am J Surg Pathol 2010; 34:556-561., 2010 Abstract

Cao D, Li J, Guo CC, Allan RW, Humphrey PA.. SALL4 is a novel diagnostic marker for testicular germ cell tumors.. Am J Surg Pathol 2009;33:1065-1077., 2009 Abstract

Sanati S, Watson MA, Salavaggione AL, Humphrey PA.. Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate.. Mod Pathol 2009; 22:1273-1279., 2009 Abstract

Song H, Zhang B, Watson MA, Humphrey PA, Lim H, Milbrandt J.. Loss of Nkx3.1 leads to activation of discrete downstream target genes during prostate tumorigenesis.. Oncogene 2009; 28:3307-3319., 2009 Abstract

Serrano MF, Katz M, Yan Y, Kibel AS, Humphrey PA. Percentage of high-grade renal cell carcinoma as a prognostic indicator in renal cell carcinoma.. Cancer 2008; 113: 477-483., 2008 Abstract

Wild PJ, Giedl J, Stoehr R, Junker K, Boehm S, van Oers JMM, Zwartoff EC, Blaszyk H, Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI, Hartmann A. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. J Pathol. 2007 Jan;(1)211:18-25, 2007 Abstract

Turbiner J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishanan A, Oliva, E. Cystic nephroma and mixed epithelial and stromal tumor of kidney : A detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol. 2007 Apr;31(4):489-500, 2007 Abstract

Humphrey PA. Diagnosis of adenocarcinoma in prostate needle biopsy tissue. J Clin Pathol 60:34-42, 2007 Abstract

Humphrey PA, Halabi S, Picus J, Sanford B, Vogelzang NJ, Small EJ, Kantoff PW. Prognostic significance of plasma scatter factor/hepatocyte growth factor levels in patients with metastatic hormone-refractory prostate cancer : Results from Cancer and Leukemia Group B 150005/9480. Clin Genitourinary Cancer 4 : 269-274, 2006 Abstract

Gokden N, Roehl KA, Catalona W, Humphrey PA. High-grade prostatic intraepithelial neoplasia in needle biopsy as a risk factor for detection of adenocarcinoma : Current level of risk in a screening population. Urology 65:538-542, 2005 Abstract

Humphrey PA. Gleason grading and prognostic factors in carcinoma of the prostate. Mod Pathol 17:292-306, 2004 Abstract

Thorson P, Swanson P, Vollmer RT, Humphrey PA. Basal cell hyperplasia in the peripheral zone of the prostate. Mod Pathol 16:598-606, 2003 Abstract

Bismar TA, Lewis JS Jr., Vollmer RT, Humphrey PA. Multiple measures of carcinoma extent versus perineural invasion in prostate needle bipsy tissue in prediction of pathologic stage in a screening population.. Am J Surg Pathol 27:432-440, 2003 Abstract

Hu Y, Ippolito JE, Garabedian EM, Humphrey PA, Gordon JI. Molecular characterization of a metastatic neuroendocrine cancer arising in the prostates of transgenic mice.. J Biol Chem 227:44462-44474, 2002 Abstract

Vollmer RT, Humphrey PA. The relative importance of anatomic and PSA factors to outcomes after radical prostatectomy for prostate cancer.. Am J Clin Pathol 116:864-870, 2001 Abstract

Naughton M, Picus J, Zhu X, Catalona WJ, Vollmer RT, Humphrey PA.. Scatter factor/hepatocyte growth factor elevation in the serum of prostate cancer patients.. J Urol 165:1325-1328, 2001 Abstract

Abdulkadir SA, Qu Z, Garabedian E, Song SK, Peters TJ, Svaren J, Carbone JM, Naughton CK, Catalona W. Impaired prostate tumorigenesis in Egr-1 deficient mice.. Nature Med 7:101-107, 2001 Abstract

Gokden N, Nappi O, Swanson PE, Pfeifer JD, Vollmer RT, Wick MR, Humphrey PA. Renal cell carcinoma with rhabdoid features. Am J Surg Pathol 24:1329-1338, 2000 Abstract

Humphrey PA, Kaleem Z, Swanson PE, Vollmer RT. Pseudohyperplastic prostatic adenocarcinoma. Am J Surg Pathol 22:1239-1246, 1998 Abstract

Garabedian EM, Humphrey PA, Gordon JI. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells. Proc Natl Acad Sci 95:15382-15387, 1998 Abstract