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Research > Faculty Alphabetical > Edward Pearce, PhD

Professor, Pathology and Immunology
Professor, Molecular Microbiology
Professor, Medicine
8th Floor, BJCIH
Office: (314) 286-2518
E-mail: edwardpearce@path.wustl.edu

Research

My laboratory studies innate and adaptive immune responses during chronic infection with the intravascular helminth parasite Schistosoma mansoni. We are particularly interested in the development and regulation of Th2 responses, which dominate during helminth infections, and the interplay between Th2 cells and cells of the innate system. This is important in the context of schistosomiasis because Th2 cells serve a protective role in this setting, allowing the host to survive while infected, and yet simultaneously cause the development of immunopathologic changes that can become severe as the infection progresses.

Selected Publications

van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL.. Mitochondrial respiratory capacity is a critical regulator of CD8(+) T cell memory development.. Immunity. 2012 Jan 27;36(1):68-78. Epub 2011 Dec 28., 2012 Abstract

Fairfax KC, Amiel E, King IL, Freitas TC, Mohrs M, Pearce EJ.. IL-10R Blockade during Chronic Schistosomiasis Mansoni Results in the Loss of B Cells from the Liver and the Development of Severe Pulmonary Disease.. PLoS Pathog. 2012 Jan;8(1):e1002490. Epub 2012 Jan 26., 2012 Abstract

Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ.. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.. Blood. 2010 Jun 10;115(23):4742-9. Epub 2010 Mar 29., 2010 Abstract

Maizels RM, Pearce EJ, Artis D, Yazdanbakhsh M, Wynn TA.. Regulation of pathogenesis and immunity in helminth infections.. J Exp Med. 2009 Sep 28;206(10):2059-66. Epub 2009 Sep 21. Review., 2009 Abstract

Zaretsky AG, Taylor JJ, King IL, Marshall FA, Mohrs M, Pearce EJ.. T follicular helper cells differentiate from Th2 cells in response to helminth antigens.. J Exp Med. 2009 May 11;206(5):991-9. Epub 2009 Apr 20., 2009 Abstract

Taylor JJ, Krawczyk CM, Mohrs M, Pearce EJ.. Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression.. J Clin Invest. 2009 Apr;119(4):1019-28. doi: 10.1172/JCI36534. Epub 2009 Mar 2., 2009 Abstract

Freitas TC, Jung E, Pearce EJ.. TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni.. PLoS Pathog. 2007 Apr;3(4):e52., 2007 Abstract