Research > Faculty By Division > Eynav Klechevsky, PhD
|Assistant Professor, Pathology and Immunology|
Office Suite B - 8210 (Room 8213 inside suite), 8th floor, BJCIH
Pub Med Search
|The ability to distinguish between physiological and pathogenic antigens and to make decisions
about how to respond to particular pathogens or a disease condition signifies a properly functioning adaptive immune system. Dendritic cells (DCs), a diverse family of antigen presenting cells, are required to explain how these specific responses are initiated and controlled. Our work on the immune system is focused on the biology of DCs in humans. Using cellular and molecular techniques we are examining the specializations that make DC subsets so adept at detecting inflammatory signals, and driving different modules of acquired immune responses. The role that individual DC subsets provide in directing adaptive immunity is also critical to our understanding human disease, and guides us in identifying new principles and practices that would hopefully lead to new treatments for some of
the challenging human diseases.
While we are interested in DCs in all organs, a major focus is given to understanding the biology of the skin DCs, which can help us understand the pathology of inflammatory skin diseases and are the major target of vaccines.
|Banchereau, J., Thompson-Snipes, L., Zurawski, S., Blanck, J.P., Cao, Y., Clayton, S., Gorvel, J.P., Zurawski, G., Klechevsky, E.. The differential production of cytokines by human Langerhans Cells and dermal CD14+ DCs controls CTL priming. Blood. Jun 14;119(24):5742-9., 2012 Abstract|
|Banchereau, J., Zurawski, S., Thompson-Snipes, L., Blanck, J.P., Clayton, S., Munk, A., Cao, Y., Wang, Z., Khandelwal, S., Hu, J., McCoy, W.H. 4th, Palucka, K.A., Reiter, Y., Fremont, D.H., Zurawski, G., Colonna, M., Shaw, A.S., Klechevsky, E.. Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming. Proc Natl Acad Sci USA. Nov 13;109(46):18885-90., 2012 Abstract|
|Ueno H, Klechevsky E, Schmitt N, Ni L, Flamar AL, Zurawski S, Zurawski G, Palucka K, Banchereau J, Oh S.. Targeting human dendritic cell subsets for improved vaccines. Semin Immunol. Feb;23(1):21-7., 2011 Abstract|
|Klechevsky E, Flamar AL, Cao Y, Blanck JP, Liu M, O. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood. Sep 9;116(10):1685-97., 2010 Abstract|
|Klechevsky E, Liu M, Morita R, Banchereau R, Thompson-Snipes L, Palucka AK, Ueno H, Banchereau J.. Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines. Hum Immunol. May;70(5):281-8., 2009 Abstract|
|Klechevsky E, Morita R, Liu M, Cao Y, Coquery S, Thompson-Snipes L, Briere F, Chaussabel D, Zurawski G, Palucka AK, Reiter Y, Banchereau J, Ueno H.. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity. Sep 19;29(3):497-510., 2008 Abstract|
|Ueno H, Klechevsky E, Morita R, Aspord C, Cao T, Matsui T, Di Pucchio T, Connolly J, Fay JW, Pascual V, Palucka AK, Banchereau J.. Dendritic cell subsets in health and disease. Immunol Rev. Oct;219:118-42. Review., 2007 Abstract|
|Klechevsky E, Kato H, Sponaas AM.. Dendritic cells star in Vancouver. J Exp Med. Jul 4;202(1):5-10., 2005 Abstract|