Faculty > Faculty By Appointment > Dengfeng Cao, MD, PhD

Associate Professor, Pathology and Immunology
Institute of Health Room 3437
Office: (314) 7475007
Pub Med Search

Service to the Department

2015 - PresentSurgical Pathology
2007 - 2012Director, Research Immunohistochemistry Lab
2007 - 2012Surgical Pathology

Diagnostic Expertise

Gynecologic Pathology, Genitourinary Pathology and Pancreatic Pathology

Clinical Interest

Anatomic and Molecular Pathology - Genitourinary Pathology
Anatomic and Molecular Pathology - General Surgical Pathology
Anatomic and Molecular Pathology - Pancreatic Pathology
Anatomic and Molecular Pathology - Gynecological Pathology

Selected Publications

Li Z, Yuan J, Wei L, Zhou L, Mei K, Yue J, Gao H, Zhang M, Jia L, Kang Q, Huang X, Cao D.. SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors.. Int J Clin Exp Pathol. 2015 Jun 1;8(6):7072-82., 2015 Abstract

Yan R, He L, Li Z, Han X, Liang J, Si W, Chen Z, Li L, Xie G, Li W, Wang P, Lei L, Zhang H, Pei F, Cao D, Sun L, Shang Y.. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.. Genes Dev. 2015 Mar 15;29(6):672-85., 2015 Abstract

Hashim YM, Trinkaus KM, Linehan DC, Strasberg SS, Fields RC, Cao D, Hawkins WG.. Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs).. Ann Surg. 2014 Feb;259(2):197-203., 2014 Abstract

Desouki MM, Lioyd J, Xu H, Cao D, Barner R, Zhao C.. CDX2 may be a useful marker to distinguish primary ovarian carcinoid from gastrointestinal metastatic carcinoids to the ovary.. Hum Pathol. 2013 Nov;44(11):2536-41., 2013 Abstract

Chen YT, Cao D, Chiu R, Lee P.. Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas.. Cancer Immun. 2013 May 10;13:10. Print 2013.Cancer Immun. 2013 May 10;13:10. Print 2013., 2013 Abstract

Cao D.. Thyroid-like follicular carcinoma of the kidney.. J Urol. 2013 Jul;190(1):278-9., 2013 Abstract

Liu TC, Hamilton N, Hawkins W, Gao F, Cao D.. Comparison of WHO Classifications (2004, 2010), the Hochwald grading system, and AJCC and ENETS staging systems in predicting prognosis in locoregional well-differentiated pancreatic neuroendocrine tumors.. Am J Surg Pathol. 2013 Jun;37(6):853-9., 2013 Abstract

Guntupalli SR, Cao D (co-first author), Shroff R, Gao F, Menias C, Stewart Massad L, Powell MA, Mutch DG, Thaker PH.. Wilms[] tumor 1 protein and estrogen receptor beta expression are associated with poor outcomes in uterine carcinosarcoma.. Ann Surg Oncol. 2013 Jul;20(7):2373-9., 2013 Abstract

Hagemann IS, Pfeifer JD, Cao D.. Mammaglobin expression in gynecologic adenocarcinomas.. Hum Pathol. 2013 Apr;44(4):628-35., 2013 Abstract

Sutton LM, Cao D, Sarode V, Molberg KH, Torgbe K, Haley B, Peng Y.. Decreased androgen receptor expression is associated with distant metastases in patients with androgen receptor-expressing triple-negative breast carcinoma.. Am J Clin Pathol. 2012 Oct;138(4):511-6., 2012 Abstract

Hudson J, Cao D, Vollmer R, Kibel AS, Grewal S, Humphrey PA.. Foamy gland adenocarcinoma of the prostate: incidence, Gleason grade, and early clinical outcome.. Hum Pathol. 2012 Jan 3. [Epub ahead of print], 2012 Abstract

Lim KH, Chung E, Khan A, Cao D, Linehan D, Ben-Josef E, Wang-Gillam A.. Neoadjuvant Therapy of Pancreatic Cancer: The Emerging Paradigm?. Oncologist. 2012;17(2):192-200., 2012 Abstract

Kunkel J, Peng Y, Tao Y, Krigman H, Cao D. Presence of a sarcomatous component outside the ovary is an adverse prognostic factor for primary ovarian malignant mixed mesodermal/mullerian tumors: a clinicopathologic study of 47 cases.. Am J Surg Pathol. 2012 Jun;36(6):831-7., 2012 Abstract

Liu Y, Fan Y, Cao D, Zhang J, Wu Z, Qiu G.. Calcitonin enhanced lumbar spinal fusion in a new zealand rabbit model: a study with morphologic and molecular analysis.. Spine (Phila Pa 1976). 2012 Feb 1;37(3):E139-46., 2012 Abstract

Cao D, Humphrey PA.. Yolk sac tumor of the testis.. J Urol. 2011 Oct;186(4):1475-, 2011 Abstract

Abbosh PH, Grubb RL 3rd, Cao D, Humphrey PA.. Hybrid renal tumors in Birt-Hogg-Dubé syndrome.. J Urol. 2011;186(6):2413-4, 2011 Abstract

Xue D, Peng Y, Wang F, Allan RW, Cao D.. RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours.. Histopathology. 2011;59(3):452-9., 2011 Abstract

Iczkowski KA, Montironi R, Cao D, Magi-Galluzzi C, Lucia MS.. Pathology update for urologists.. Prostate Cancer. 2011;2011:183761. Epub 2011 Sep 25., 2011 Abstract

Han JS, Cao D, Molberg KH, Sarode VR, Rao R, Sutton LM, Peng Y.. Hormone Receptor Status Rather Than HER2 Status Is Significantly Associated With Increased Ki-67 and p53 Expression in Triple-Negative Breast Carcinomas, and High Expression of Ki-67 but Not p53 Is Significantly Associated With Axillary Nodal Metastasis i. Am J Clin Pathol. 2011;135(2):230-7., 2011 Abstract

Cao D, Humphrey PA, Gao F, Tao Y, Kibel AS.. Ability of Linear Length of Positive Margin in Radical Prostatectomy Specimens to Predict Biochemical Recurrence.. Urology. 2011 Jun;77(6):1409-14., 2011 Abstract

Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N, Akhi S, Li J.. RNA-binding protein LIN28 is a marker for testicular germ cell tumors.. Hum Pathol. 2011;42(5):710-8., 2011 Abstract

Cao D, Liu A, Wang F, Allan RW, Mei K, Peng Y, Du J, Guo S, Abel TW, Lane Z, Ma J, Rodriguez M, Akhi S, Dehiya N, Li J.. RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases.. Mod Pathol. 2011;24(2):288-96., 2011 Abstract

Jeung JA, Cao D, Selli BW, Clapp WL, Oliai BR, Parwani AV, Allan RW.. Primary renal carcinoid tumors: clinicopathologic features of 9 cases with emphasis on novel immunohistochemical findings.. Hum Pathol. 2011 Oct;42(10):1554-61., 2011 Abstract

Shi H, Cao D, Wei L, Sun L, Guo A.. Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males.. Virchows Arch. 2010;456(1):65-70., 2010 Abstract

Yaskiv O, Cao D, Humphrey PA.. Microcystic Adenocarcinoma of the Prostate: A Variant of Pseudohyperplastic and Atrophic Patterns.. Am J Surg Pathol. 2010;34(4):556-61., 2010 Abstract

Cao D, Begum S, Ali SZ, Westra WH.. Expression of p16 in benign and malignant cystic squamous lesions of the neck.. Hum Pathol. 2010;41(4):535-9, 2010 Abstract

Cao D, Vollmer RT, Luly J, Jain S, Roytman TM, Ferris CW, Hudson ML.. Comparison of 2004 and 1973 World Health Organization Grading Systems and Their Relationship to Pathologic Staging for Predicting Long-term Prognosis in Patients With Urothelial Carcinoma.. Urology. 2010;76(3):593-9, 2010 Abstract

Liu A, Cheng L, Du J, Peng Y, Allan RW, Wei L, Li J, Cao D.. Diagnostic Utility of Novel Stem Cell Markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in Primary Mediastinal Germ Cell Tumors.. Am J Surg Pathol. 2010;34(5):697-706, 2010 Abstract

Cao D, Kibel AS, Gao F, Tao Y, Humphrey PA.. The Gleason Score of Tumor at the Margin in Radical Prostatectomy is Predictive of Biochemical Recurrence.. Am J Surg Pathol. 2010;34(7):994-1001., 2010 Abstract

Cao D, Lane Z, Allan RW, Wang P, Guo CC, Peng Y, Li J.. TCL1 is a diagnostic marker for intratubular germ cell neoplasia and classic seminoma.. Histopathology. 2010;57(1):152-7., 2010 Abstract

Shi H, Wang C, Wei L, Lu S, Cao D.. Malignant mesenchymoma of the thyroid: case report and literature review.. Tumori. 2010;96(2):345-8, 2010 Abstract

Shi H, Cao D, Wei L, Sun L, Guo A.. Inflammatory angiomyolipomas of the liver: a clinicopathologic and immunohistochemical analysis of 5 cases.. Ann Diagn Pathol. 2010 Aug;14(4):240-6, 2010 Abstract

Lindberg MR, Fisher C, Thway K, Cao D, Cheville JC, Folpe AL.. Leiomyosarcoma of the urinary bladder: a clinicopathological study of 34 cases.. J Clin Pathol. 2010;63(8):708-13., 2010 Abstract

Wang P, Li J, Allan RW, Guo CC, Peng Y, Cao D.. Expression of UTF1 in Primary and Metastatic Testicular Germ Cell Tumors.. Am J Clin Pathol. 2010;134(4):604-612., 2010 Abstract

Sutton LM, Han JS, Molberg KH, Sarode VR, Cao D, Rakheja D, Sailors J, Peng Y.. Intratumoral expression level of epidermal growth factor receptor and cytokeratin 5/6 is significantly associated with nodal and distant metastases in patients with basal-like triple-negative breast carcinoma.. Am J Clin Pathol. 2010 ;134(5):782-7., 2010 Abstract

Cao D, Guo S, Allan RW, Molberg KH, Peng Y. SALL4 Is a Novel Sensitive and Specific Marker of Ovarian Primitive Germ Cell Tumors and Is Particularly Useful in Distinguishing Yolk Sac Tumor From Clear Cell Carcinoma.. Am J Surg Pathol. 2009;33(6):894-904., 2009 Abstract

Cao D, Humphrey PA, Allan RW. SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors.. Cancer. 2009;15(12):2640-51., 2009 Abstract

Arroyo MR, Podda A, Cao D, Rodriguez MM.. Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty.. Pediatr Dev Pathol. 2009; 12(1): 73-76., 2009 Abstract

Cao D, Li J, Guo CC, Allan RW, Humphrey PA. SALL4 Is a Novel Diagnostic Marker for Testicular Germ Cell Tumors.. Am J Surg Pathol. 2009;33(7):1065-1077., 2009 Abstract

Wang F, Liu A, Peng Y, Rakheja D, Wei L, Xue D, Allan RW, Molberg KH, Li J, Cao D.. Diagnostic Utility of SALL4 in Extragonadal Yolk Sac Tumors: An Immunohistochemical Study of 59 Cases With Comparison to Placental-like Alkaline Phosphatase, Alpha-fetoprotein, and Glypican-3.. Am J Surg Pathol. 2009;33:1529-1539, 2009 Abstract

Mei K, Liu A, Allan RW, Wang P, Lane Z, Abel TW, Wei L, Cheng H, Guo S, Peng Y, Rakheja D, Wang M, Ma J, Rodriguez MM, Li J, Cao D. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases.. Mod Pathol. 2009;22(12):1628-36, 2009 Abstract

Kibel AS, Dehdashti F, Katz MD, Klim AP, Grubb RL, Humphrey PA, Siegel C, Cao D, Gao F, Siegel BA.. Prospective study of [18F]fluorodeoxyglucose positron emission tomography/computed tomography for staging of muscle-invasive bladder carcinoma.. J Clin Oncol. 2009;27(26):4314-20, 2009 Abstract

Cao D, Tsangaris TN, Kouprina N, Wu LS, Balch CM, Vang R, Argani P. The Superficial Margin of the Skin-Sparing Mastectomy for Breast Carcinoma: Factors Predicting Involvement and Efficacy of Additional Margin Sampling.. Annals of Surgical Oncology 15:1330-1340., 2008 Abstract

Lollar K, Farrag TY, Cao D, Niparko J, Tufano RP.. Langerhans cell histiocytosis of the thyroid gland.. Am J Otolaryngol.29(3):201-4., 2008 Abstract

Cao D, Ashfaq R, Goggins MG, Hruban RH, Kern SE and Iacobuzio-Donahue CA.. Differential Expression of Multiple Genes in Association with MADH4/DPC4/SMAD4 Inactivation in Pancreatic Cancer.. Int J Clin Exp Pathol. 2008;1(6):510-7., 2008 Abstract

Cao D, Polyak K, Halushka MK, Nassar H, Kouprina N, Iacobuzio-Donahue C, Wu X, Sukumar S, Hicks J, De Marzo A, Argani P. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9.. Breast Cancer Res. 2008;10(5):R91., 2008 Abstract

Cheung WL, Cao D.. Colonic-type adenocarcinoma arising in a primary retroperitoneal mature cystic teratoma.. Pathol Int. 2008;58(12):792-6., 2008 Abstract

Cao D, Zhang Q, Wu LS, Salaria SN, Winter JW, Hruban RH, Goggins MS, Abbruzzese JL, Maitra A, Ho L. Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. Mod Pathol. 20(5):570-8., 2007 Abstract

Lee KM, Cao D (co-first author), Itami A, Pour PM, Hruban RH, Maitra A, Ouellette MM. Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia.. Histopathology.51(4):539-46., 2007 Abstract

Lai V, Farrag TY, Cao D, Aygun N, Boahene K, Tufano RP. Synovial sarcoma of the infratemporal fossa.. Am J Otolaryngol.28(6):444-7., 2007 Abstract

Cao D, Antonescu C, Wong G, Winter J, Maitra A, Adsay NV, Klimstra DS, Hruban RH. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations.. Mod Pathol. 19(9):1157-63., 2006 Abstract

Cao D, Lin C, Woo SH, Vang R, Tsangaris TN, Argani P.. Separate cavity margin sampling at the time of initial breast lumpectomy significantly reduces the need for reexcisions.. Am J Surg Pathol. 29(12):1625-32., 2005 Abstract

Cao D, Wilentz RE, Abbruzzese JL, Ho L, Maitra A.. Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.. Int J Gastrointest Cancer.36(1):39-46., 2005 Abstract

Begum S, Cao D, Gillison M, Zahurak M, Westra WH.. Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma.. Clin Cancer Res. 11(16):5694-9., 2005 Abstract

Cao D, Srodon M, Montgomery EA, Kurman RJ.. Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature.. Int J Gynecol Pathol. 24(2):196-200., 2005 Abstract

Cao D, Hafez M, Berg K, Murphy K, Epstein JI.. Little or no residual prostate cancer at radical prostatectomy: vanishing cancer or switched specimen?: a microsatellite analysis of specimen identity.. Am J Surg Pathol. 29(4):467-73., 2005 Abstract

Cao D, Maitra A, Saavedra JA, Klimstra DS, Adsay NV, Hruban RH.. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.. Mod Pathol. 18(6):752-61., 2005 Abstract

Cao D, Ji H, Ronnett BM.. Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary.. Int J Gynecol Pathol. 24(1):67-72., 2005 Abstract

Singer G, Stöhr R, Cope L, Dehari R, Hartmann A, Cao DF, Wang TL, Kurman RJ, Shih IeM.. Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation.. Am J Surg Pathol. 2005;29(2):218-24., 2005 Abstract

Hustinx SR, Cao D (co-first author), Maitra A, Sato N, Martin ST, Sudhir D, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Kern SE, Goggins M, Mollenhauer J, Pandey A, Hruban RH.. Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression.. Cancer Biol Ther. 3(12):1254-61, 2004 Abstract

Cao D, Hustinx SR, Sui G, Bala P, Sato N, Martin S, Maitra A, Murphy KM, Cameron JL, Yeo CJ, Kern SE, Goggins M, Pandey A, Hruban RH.. Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags.. Cancer Biol Ther. 3(11):1081-9., 2004 Abstract

Parwani AV, Cao D, Epstein JI.. Pathologic quiz case: a 35-year-old man with hematuria. Paraganglioma involving the prostate.. Arch Pathol Lab Med.128(8):e104-6, 2004 Abstract

Wang LF, Zhu HD, Miao SY, Cao DF, Wu YW, Zong SD, Koide SS.. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene.. Arch Androl. 1999;42(2):71-84, 1999 Abstract